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An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion

Year 2023, , 146 - 150, 31.08.2023
https://doi.org/10.47493/abantmedj.1324250

Abstract

One of the most frequent causes of seizures in children is an acute symptomatic seizure. To forecast risk of recurrence of seizure, it's crucial to identify the trigger element at the root of the problem. Cyanide inhibits cell oxygen utilization and cellular respiration through inactivation of mitochondrial cytochrome oxidase. Cyanide is one of the most lethal toxins ever discovered for the human body. Early treatment enables the avoidance of harmful outcomes, including death. This case report represents case of a 2-year-old girl presented with an acute symptomatic seizure after eating a few apricot kernels and her quick recovery with antidote after cyanide poisoning was suspected. The patient was discharged without experiencing any long-term effects of cyanide poisoning.

Supporting Institution

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References

  • Nardone R, Brigo F, Trinka E. Acute Symptomatic Seizures Caused by Electrolyte Disturbances. J Clin Neurol. 2016 ;12(1):21-33. doi: 10.3988/jcn.2016.12.1.21.
  • Peddy SB, Rigby MR, Shaffner DH. Acute cyanide poisoning. Pediatr Crit Care Med. 2006;7(1):79-82. doi: 10.1097/01.pcc.0000192508.92993.d1.
  • Geller RJ, Barthold C, Saiers JA, Hall AH. Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs. Pediatrics. 2006; 118(5):2146-58. doi: 10.1542/peds.2006-1251.
  • Geslain G, Tilea B, Heraut F, Rubinsztajn R. Smoke inhalation injury in a 2-year-old domestic fire victim. Arch Pediatr. 2020 May;27(4):223-226. doi: 10.1016/j.arcped.2020.01.008.
  • Akıl M, Kaya A, Ustyol L, Aktar F, Akbayram S. Acute cyanide intoxication due to apricot seed ingestion. J Emerg Med. 2013; 44(2):e285-6. doi: 10.1016/j.jemermed.2012.05.041.
  • Unal O, Ozen O, Caksen H. Acute Cyanide Intoxication Related to Apricot Seed: The Findings of Cranial Magnetic Resonance Imaging. J.Neurol.Sci. 2016; 33(1); 171-176.
  • Yulvianti M, Zidorn C. Chemical Diversity of Plant Cyanogenic Glycosides: An Overview of Reported Natural Products. Molecules. 2021;26(3):719. doi: 10.3390/molecules26030719.
  • Zhang D, Ye J, Song Y, Wei Y, Jiang S, Chen Y, Shao X. Isomerization and Stabilization of Amygdalin from Peach Kernels. Molecules. 2023;28(11):4550. doi: 10.3390/molecules28114550.
  • Cigolini D, Ricci G, Zannoni M, et al. Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels. BMJ Case Rep. 2011;bcr0320113932. doi: 10.1136/bcr.03.2011.3932.
  • Leavesley HB, Li L, Prabhakaran K, Borowitz JL, Isom GE. Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci. 2008;101(1):101-11. doi: 10.1093/toxsci/kfm254.
  • Chen F, Jiang L, Yang B. Visual loss caused by acute cyanide poisoning: a case report. Clin Toxicol (Phila). 2011;49(2):121-3. doi: 10.3109/15563650.2011.556643.
  • Cmorej P, Bruthans P, Halamka J, Voriskova I, Peran D. Life-Threatening Cyanide Intoxication after Ingestion of Amygdalin in Prehospital Care. Prehosp Emerg Care. 2022;26(3):455-458. doi: 10.1080/10903127.2021.1924903.
  • Schwarz ES. Inhalants. Crit Care Clin. 2021;37(3):687-702. doi: 10.1016/j.ccc.2021.03.014.
  • Graham J, Traylor J. Cyanide Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. 2023 Feb 13.
  • Bıcılıoğlu Y, Yıldırım İ, Özkaya PY, Bal A. Pediatric cyanide poisoning after ingestion of apricotseeds. JPediatr Emerg Intensive Care Med. 2020;7(2):85-8.
  • Rice NC, Rauscher NA, Langston JL, Myers TM. Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery. Food Chem Toxicol 2018;114:145–54. https://doi.org/10.1016/J.FCT.2018.02.033.
  • Moffett BS, Price JF. Evaluation of sodium nitroprusside toxicity in pediatric cardiac surgical patients. Ann Pharmacother 2008;42:1600–4. https://doi.org/10.1345/APH.1L192.
  • Thomas C, Svehla L, Moffett BS. Sodium-nitroprusside-induced cyanide toxicity in pediatric patients. Expert Opin Drug Saf 2009;8:599–602. https://doi.org/10.1517/14740330903081717.

Çocuklarda akut semptomatik nöbetin oldukça nadir bir nedeni: Kayısı çekirdeği yutulması

Year 2023, , 146 - 150, 31.08.2023
https://doi.org/10.47493/abantmedj.1324250

Abstract

Çocuklukta nöbetlerin en sık nedenlerinden biri akut semptomatik nöbettir. Nöbetin tekrarlama riskini tahmin etmek için sorunun kökündeki tetikleyici unsuru belirlemek çok önemlidir. Siyanür, mitokondriyal sitokrom oksidazın inaktivasyonu yoluyla hücre oksijen kullanımını ve hücresel solunumu inhibe eder. Siyanür, insan vücudu için şimdiye kadar keşfedilen en öldürücü toksinlerden biridir. Erken tedavi, ölüm dahil zararlı sonuçların önlenmesini sağlar. Bu vaka sunumu, birkaç kayısı çekirdeği yedikten sonra akut semptomatik nöbet ile başvuran ve siyanür zehirlenmesinden şüphelenildikten sonra panzehirle hızla iyileşen 2 yaşındaki bir kız çocuğunu sunmaktadır. Hasta siyanür zehirlenmesinin uzun süreli etkisi görülmeden taburcu edilmiştir.

References

  • Nardone R, Brigo F, Trinka E. Acute Symptomatic Seizures Caused by Electrolyte Disturbances. J Clin Neurol. 2016 ;12(1):21-33. doi: 10.3988/jcn.2016.12.1.21.
  • Peddy SB, Rigby MR, Shaffner DH. Acute cyanide poisoning. Pediatr Crit Care Med. 2006;7(1):79-82. doi: 10.1097/01.pcc.0000192508.92993.d1.
  • Geller RJ, Barthold C, Saiers JA, Hall AH. Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs. Pediatrics. 2006; 118(5):2146-58. doi: 10.1542/peds.2006-1251.
  • Geslain G, Tilea B, Heraut F, Rubinsztajn R. Smoke inhalation injury in a 2-year-old domestic fire victim. Arch Pediatr. 2020 May;27(4):223-226. doi: 10.1016/j.arcped.2020.01.008.
  • Akıl M, Kaya A, Ustyol L, Aktar F, Akbayram S. Acute cyanide intoxication due to apricot seed ingestion. J Emerg Med. 2013; 44(2):e285-6. doi: 10.1016/j.jemermed.2012.05.041.
  • Unal O, Ozen O, Caksen H. Acute Cyanide Intoxication Related to Apricot Seed: The Findings of Cranial Magnetic Resonance Imaging. J.Neurol.Sci. 2016; 33(1); 171-176.
  • Yulvianti M, Zidorn C. Chemical Diversity of Plant Cyanogenic Glycosides: An Overview of Reported Natural Products. Molecules. 2021;26(3):719. doi: 10.3390/molecules26030719.
  • Zhang D, Ye J, Song Y, Wei Y, Jiang S, Chen Y, Shao X. Isomerization and Stabilization of Amygdalin from Peach Kernels. Molecules. 2023;28(11):4550. doi: 10.3390/molecules28114550.
  • Cigolini D, Ricci G, Zannoni M, et al. Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels. BMJ Case Rep. 2011;bcr0320113932. doi: 10.1136/bcr.03.2011.3932.
  • Leavesley HB, Li L, Prabhakaran K, Borowitz JL, Isom GE. Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci. 2008;101(1):101-11. doi: 10.1093/toxsci/kfm254.
  • Chen F, Jiang L, Yang B. Visual loss caused by acute cyanide poisoning: a case report. Clin Toxicol (Phila). 2011;49(2):121-3. doi: 10.3109/15563650.2011.556643.
  • Cmorej P, Bruthans P, Halamka J, Voriskova I, Peran D. Life-Threatening Cyanide Intoxication after Ingestion of Amygdalin in Prehospital Care. Prehosp Emerg Care. 2022;26(3):455-458. doi: 10.1080/10903127.2021.1924903.
  • Schwarz ES. Inhalants. Crit Care Clin. 2021;37(3):687-702. doi: 10.1016/j.ccc.2021.03.014.
  • Graham J, Traylor J. Cyanide Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. 2023 Feb 13.
  • Bıcılıoğlu Y, Yıldırım İ, Özkaya PY, Bal A. Pediatric cyanide poisoning after ingestion of apricotseeds. JPediatr Emerg Intensive Care Med. 2020;7(2):85-8.
  • Rice NC, Rauscher NA, Langston JL, Myers TM. Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery. Food Chem Toxicol 2018;114:145–54. https://doi.org/10.1016/J.FCT.2018.02.033.
  • Moffett BS, Price JF. Evaluation of sodium nitroprusside toxicity in pediatric cardiac surgical patients. Ann Pharmacother 2008;42:1600–4. https://doi.org/10.1345/APH.1L192.
  • Thomas C, Svehla L, Moffett BS. Sodium-nitroprusside-induced cyanide toxicity in pediatric patients. Expert Opin Drug Saf 2009;8:599–602. https://doi.org/10.1517/14740330903081717.
There are 18 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Case Report
Authors

İpek Dokurel 0000-0002-1820-8980

Cansen Çeneli This is me 0009-0003-8788-2332

Early Pub Date August 28, 2023
Publication Date August 31, 2023
Submission Date July 7, 2023
Published in Issue Year 2023

Cite

APA Dokurel, İ., & Çeneli, C. (2023). An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Medical Journal, 12(2), 146-150. https://doi.org/10.47493/abantmedj.1324250
AMA Dokurel İ, Çeneli C. An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Med J. August 2023;12(2):146-150. doi:10.47493/abantmedj.1324250
Chicago Dokurel, İpek, and Cansen Çeneli. “An Extremely Rare Cause of Acute Symptomatic Seizure in Toddlers: Apricot Seed Ingestion”. Abant Medical Journal 12, no. 2 (August 2023): 146-50. https://doi.org/10.47493/abantmedj.1324250.
EndNote Dokurel İ, Çeneli C (August 1, 2023) An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Medical Journal 12 2 146–150.
IEEE İ. Dokurel and C. Çeneli, “An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion”, Abant Med J, vol. 12, no. 2, pp. 146–150, 2023, doi: 10.47493/abantmedj.1324250.
ISNAD Dokurel, İpek - Çeneli, Cansen. “An Extremely Rare Cause of Acute Symptomatic Seizure in Toddlers: Apricot Seed Ingestion”. Abant Medical Journal 12/2 (August 2023), 146-150. https://doi.org/10.47493/abantmedj.1324250.
JAMA Dokurel İ, Çeneli C. An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Med J. 2023;12:146–150.
MLA Dokurel, İpek and Cansen Çeneli. “An Extremely Rare Cause of Acute Symptomatic Seizure in Toddlers: Apricot Seed Ingestion”. Abant Medical Journal, vol. 12, no. 2, 2023, pp. 146-50, doi:10.47493/abantmedj.1324250.
Vancouver Dokurel İ, Çeneli C. An extremely rare cause of acute symptomatic seizure in toddlers: Apricot seed ingestion. Abant Med J. 2023;12(2):146-50.