Hormon Reseptör Pozitif, İnsan Epidermal Büyüme Faktörü Reseptör2 Negatif Metastatik Meme Kanserli Hastalarda Tedavi Seçenekleri

Year 2020, , 145 - 153, 21.12.2020

Ümmügül Üyetürk

https://doi.org/10.47493/abantmedj.2020.25

Abstract

Meme kanserleri(MK) kadınlarda en sık görülen ve ikinci sıklıkta ölüme neden olan kanserlerdir. Hastaların %3-8 metastatik evrede tanı almakta, %40’unda da takipte metastaz gelişmektedir. Bu hastaların tedavisinde visseral kriz veya endokrin tedavi direnci yoksa östrojen hormonunun reseptörlere bağlanmasını engelleyici ya da östrojen üretimini azaltıcı endokrin tedavi önerilmektedir. Çünkü metastatik MK hastalarda çok istisnai vakalar dışında kür sağlanamamaktadır. Hastalarda semptom kontrolü, hastalık progresyonunun geciktirilmesi ve hastalık progresyonuna bağlı ciddi komplikasyonlardan önlenmesi, yaşam kalitesin devam ettirebilmesi ve sonuçta sağkalım süresinin uzatılmaya çalışılmalıdır. Hastaların pre/perimenapozal veya menapozal dönemde olup olmadıkları tedavi seçiminde önemlidir. Pre/perimenapozal dönemde selektif östrojen reseptör modülatörleri (Tamoksifen), progresyon olduğunda over ablasyonu/ supresyon ile birlikte postmenapozal dönemdeki tedaviler kullanılabilir. Postmenapozal dönemde ise Tamoksifen, Aromataz inhibitörleri: nonsteroidal (Letrozol veya Anastrozol) ve steroidal (Exemestan), östrojen reseptör down regülatörü (Fulvestrant) seçenekler arasındadır. Ayrıca endokrin tedavilere direnç gelişimi durumunda etkinliğinin artırılması amacıyla siklin bağımlı kinaz 4/6 inhibitörleri (Palbociclib, Ribociclib, Abemaciclib), ve mTOR inhibitörü (Everolimus), fosfotidil inositol 3 kinaz inhibitörü (Buparlisib) gibi hedefe yönelik moleküllerle kombinasyon tedavileri uygulanabilir. Ayrıca hedefe yönelik tedavilerin endokrin tedavilerle kombinasyonları etkinliğini artırmaktadır.

Keywords

Metastatik Meme Kanseri, Endokrin Tedavi, Siklin Bağımlı Kinaz 4/6 İnhibitörleri, mTOR inhibitörü, Fosfotidil İnositol 3 Kinaz İnhibitörleri

Supporting Institution

derleme makalemizin finansal desteği bulunmamaktadır.

References

• 1. DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Goding Sauer A, et al. Breast cancer statistics, 2019. CA: a cancer journal for clinicians. 2019 Nov;69(6):438-51. PubMed PMID: 31577379. Epub 2019/10/03. eng.
• 2. Nadji M, Gomez-Fernandez C, Ganjei-Azar P, Morales AR. Immunohistochemistry of estrogen and progesterone receptors reconsidered: experience with 5,993 breast cancers. American journal of clinical pathology. 2005 Jan;123(1):21-7. PubMed PMID: 15762276. Epub 2005/03/15. eng.
• 3. Allison KH, Hammond MEH, Dowsett M, McKernin SE, Carey LA, Fitzgibbons PL, et al. Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update. Archives of pathology & laboratory medicine. 2020 Jan 13. PubMed PMID: 31928354. Epub 2020/01/14. eng.
• 4. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians. 2011 Mar-Apr;61(2):69-90. PubMed PMID: 21296855. Epub 2011/02/08. eng.
• 5. Cardoso F, Senkus E, Costa A, Papadopoulos E, Aapro M, Andre F, et al. 4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)dagger. Annals of oncology : official journal of the European Society for Medical Oncology. 2018 Aug 1;29(8):1634-57. PubMed PMID: 30032243. Epub 2018/07/23. eng.
• 6. Giuliano M, Schettini F, Rognoni C, Milani M, Jerusalem G, Bachelot T, et al. Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis. The Lancet Oncology. 2019 Oct;20(10):1360-9. PubMed PMID: 31494037. Epub 2019/09/09. eng.
• 7. Cruz Jurado J, Richart Aznar P, Garcia Mata J, Fernandez Martinez R, Pelaez Fernandez I, Sampedro Gimeno T, et al. Management of patients with metastatic breast cancer. Advances in therapy. 2011 Sep;28 Suppl 6:50-65. PubMed PMID: 21922395. Epub 2011/09/23. eng.
• 8. Sbitti Y, Slimani K, Debbagh A, Mokhlis A, Kadiri H, Laraqui A, et al. Visceral Crisis Means Short Survival Among Patients With Luminal A Metastatic Breast Cancer: A Retrospective Cohort Study. World journal of oncology. 2017 Aug;8(4):105-9. PubMed PMID: 29147444. Pubmed Central PMCID: PMC5650006. Epub 2017/11/18. eng.
• 9. Harb WA. Management of patients with hormone receptor-positive breast cancer with visceral disease: challenges and treatment options. Cancer management and research. 2015;7:37-46. PubMed PMID: 25653556. Pubmed Central PMCID: PMC4310719. Epub 2015/02/06. eng.
• 10. Shagufta, Ahmad I. Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. European journal of medicinal chemistry. 2018 Jan 1;143:515-31. PubMed PMID: 29207335. Epub 2017/12/06. eng.
• 11. Harvey LFB, Abramson VG, Alvarez J, DeStephano C, Hur HC, Lee K, et al. Surgical Findings and Outcomes in Premenopausal Breast Cancer Patients Undergoing Oophorectomy: A Multicenter Review From the Society of Gynecologic Surgeons Fellows Pelvic Research Network. Journal of minimally invasive gynecology. 2018 Jan;25(1):111-5. PubMed PMID: 28821472. Epub 2017/08/20. eng.
• 12. Bui KT, Willson ML, Goel S, Beith J, Goodwin A. Ovarian suppression for adjuvant treatment of hormone receptor-positive early breast cancer. The Cochrane database of systematic reviews. 2020 Mar 6;3:CD013538. PubMed PMID: 32141074. Pubmed Central PMCID: PMC7059882. Epub 2020/03/07. eng.
• 13. Noguchi S, Kim HJ, Jesena A, Parmar V, Sato N, Wang HC, et al. Phase 3, open-label, randomized study comparing 3-monthly with monthly goserelin in pre-menopausal women with estrogen receptor-positive advanced breast cancer. Breast cancer (Tokyo, Japan). 2016 Sep;23(5):771-9. PubMed PMID: 26350351. Pubmed Central PMCID: PMC4999470. Epub 2015/09/10. eng.
• 14. Balam FH, Ahmadi ZS, Ghorbani A. Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review. Heliyon. 2020 Mar;6(3):e03557. PubMed PMID: 32181408. Pubmed Central PMCID: PMC7063143. Epub 2020/03/18. eng.
• 15. Smith IE, Dowsett M. Aromatase inhibitors in breast cancer. The New England journal of medicine. 2003 Jun 12;348(24):2431-42. PubMed PMID: 12802030. Epub 2003/06/13. eng.
• 16. Irish W, Sherrill B, Cole B, Gard C, Glendenning GA, Mouridsen H. Quality-adjusted survival in a crossover trial of letrozole versus tamoxifen in postmenopausal women with advanced breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology. 2005 Sep;16(9):1458-62. PubMed PMID: 15946978. Epub 2005/06/11. eng.
• 17. Mouridsen H, Chaudri-Ross HA. Efficacy of first-line letrozole versus tamoxifen as a function of age in postmenopausal women with advanced breast cancer. The oncologist. 2004;9(5):497-506. PubMed PMID: 15477634. Epub 2004/10/13. eng.
• 18. Nathan MR, Schmid P. A Review of Fulvestrant in Breast Cancer. Oncology and therapy. 2017;5(1):17-29. PubMed PMID: 28680952. Pubmed Central PMCID: PMC5488136. Epub 2017/07/07. eng.
• 19. Di Leo A, Jerusalem G, Petruzelka L, Torres R, Bondarenko IN, Khasanov R, et al. Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 Oct 20;28(30):4594-600. PubMed PMID: 20855825. Epub 2010/09/22. eng.
• 20. Robertson JF, Llombart-Cussac A, Rolski J, Feltl D, Dewar J, Macpherson E, et al. Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Sep 20;27(27):4530-5. PubMed PMID: 19704066. Epub 2009/08/26. eng.
• 21. Robertson JFR, Bondarenko IM, Trishkina E, Dvorkin M, Panasci L, Manikhas A, et al. Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial. Lancet (London, England). 2016 Dec 17;388(10063):2997-3005. PubMed PMID: 27908454. Epub 2016/12/03. eng.
• 22. Malumbres M. Cyclin-dependent kinases. Genome biology. 2014;15(6):122. PubMed PMID: 25180339. Pubmed Central PMCID: PMC4097832. Epub 2014/09/03. eng.
• 23. Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. The Lancet Oncology. 2015 Jan;16(1):25-35. PubMed PMID: 25524798. Epub 2014/12/20. eng.
• 24. Rugo HS, Finn RS, Gelmon K, Joy AA, Harbeck N, Castrellon A, et al. Progression-free Survival Outcome Is Independent of Objective Response in Patients With Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Advanced Breast Cancer Treated With Palbociclib Plus Letrozole Compared With Letrozole: Analysis From PALOMA-2. Clinical breast cancer. 2019 Sep 5. PubMed PMID: 31836434. Epub 2019/12/15. eng.
• 25. Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, et al. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. The Lancet Oncology. 2016 Apr;17(4):425-39. PubMed PMID: 26947331. Epub 2016/03/08. eng.
• 26. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer. The New England journal of medicine. 2018 Dec 27;379(26):2582. PubMed PMID: 30586508. Epub 2018/12/27. eng.
• 27. Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, et al. Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Aug 20;36(24):2465-72. PubMed PMID: 29860922. Epub 2018/06/05. eng.
• 28. Tripathy D, Im SA, Colleoni M, Franke F, Bardia A, Harbeck N, et al. Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial. The Lancet Oncology. 2018 Jul;19(7):904-15. PubMed PMID: 29804902. Epub 2018/05/29. eng.
• 29. Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, et al. MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Nov 10;35(32):3638-46. PubMed PMID: 28968163. Epub 2017/10/03. eng.
• 30. Sledge GW, Jr., Toi M, Neven P, Sohn J, Inoue K, Pivot X, et al. MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2- Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Sep 1;35(25):2875-84. PubMed PMID: 28580882. Epub 2017/06/06. eng.
• 31. Sobhani N, D'Angelo A, Pittacolo M, Roviello G, Miccoli A, Corona SP, et al. Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer. Cells. 2019 Apr 6;8(4). PubMed PMID: 30959874. Pubmed Central PMCID: PMC6523967. Epub 2019/04/10. eng.
• 32. Hasskarl J. Everolimus. Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le cancer. 2018;211:101-23. PubMed PMID: 30069763. Epub 2018/08/03. eng.
• 33. Baselga J, Campone M, Piccart M, Burris HA, 3rd, Rugo HS, Sahmoud T, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. The New England journal of medicine. 2012 Feb 9;366(6):520-9. PubMed PMID: 22149876. Pubmed Central PMCID: PMC5705195. Epub 2011/12/14. eng.
• 34. Bachelot T, Bourgier C, Cropet C, Ray-Coquard I, Ferrero JM, Freyer G, et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Aug 1;30(22):2718-24. PubMed PMID: 22565002. Epub 2012/05/09. eng.
• 35. Campone M, Im SA, Iwata H, Clemons M, Ito Y, Awada A, et al. Buparlisib plus fulvestrant versus placebo plus fulvestrant for postmenopausal, hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer: Overall survival results from BELLE-2. European journal of cancer (Oxford, England: 1990). 2018 Nov;103:147-54. PubMed PMID: 30241001. Epub 2018/09/22. eng.