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QT Dispersion Which Predicts Cardiovascular Adverse Event Risk, Increases In Non Alcoholic Fatty Liver Disease

Year 2014, , 33 - 37, 01.01.2014

Ahmet Oğuz Baktır Bahadır Şarlı Ahmet Karaman Hüseyin Arınç Hayrettin Sağlam Hatice Karaman Abdülsamed Erden Yasemin Doğan

https://doi.org/10.5505/abantmedj.2014.00710

Abstract

OBJECTIVE: Association of cardiovascular morbidity and mortality with non alcoholic fatty liver disease NAFLD is increasing rapidly. The QT dispersion QTd and QT corrected dispersion QTcd reflects the heterogeneity of ventricular repolarisation.Predicting cardiovascular risk of an increased QTd and QTcd has been shown in various clinical cardiovascular and non cardiovasculer groups, but has not yet been studied in NAFLD patients according to our search of literature. We hypothesised that NAFLD related heart injury may cause myocardial repolarisation abnormalities. METHODS: Forty five patients admitted to the department of gastroenterology outpatient clinic with the diagnose of NAFLD were included in this study. QT intervals were measured manually from the onset of QRS to the end of the T wave defined as a return to the T–P baseline.RESULTS: We found that QT dispersion 47.8±22.7 vs 22.5±7.5 ms, p

Keywords

QT dispersion non alcoholic fatty liver dısease cardiovascular risk

References

  • Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E, Grimaldi A, Capron F, Poynard T. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898–906.
  • Bugianesi E. Nonalcoholic fatty liver disease (NAFLD) and cardiac lipotoxicity: Another piece of the puzzle. Hepatology 2008; 47: 2–4.
  • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009; 49: 306–17.
  • JC, Molnar J. Usefulness of QT dispersion as an electrocardiographically derived index. Am J Cardiol, 2002; 89: 291–29
  • Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 1994; 343: 327–329.
  • Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 2001; 26: 321-31
  • Sevimli S, Arslan S, Gündoğdu F. Carvedilol therapy is associated with improvement in QT dispersion in patients with congestive heart failure. Arch Turk Soc Cardiol 2007; 35:284-288.
  • Glancy JM, Garratt CJ, Woods KI, Bono DP. QT dispersion and mortality after myocardial infarction. Lancet 1995; 345: 945–948.
  • Zabel M, Woosly RL, Franz MR. Is dispersion of ventricular repolarisation rate dependent? PACE 1997; 20(Part I): 2405–2411.
  • Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369–75.
  • Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009; 106: 15430–5.
  • Salamone F, Bugianesi E. Nonalcoholic fatty liver disease: the hepatic trigger of the metabolic syndrome. J Hepatol 2011; 53: 1146–7.
  • Lautamäki R, Borra R, Iozzo P, Komu M, Lehtimäki T, Salmi M, Jalkanen S, Airaksinen KE, Knuuti J, Parkkola R, Nuutila P. Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. Am J Physiol Endocrinol Metab 2006; 291: 282–90.
  • Speliotes EK, Massaro JM, Hoffmann U, Vasan RS, Meigs JB, Sahani DV, Hirschhorn JN, O'Donnell CJ, Fox CS. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010; 51: 1979–87.
  • Salamone F, Galvano F, Li Volti G. Treating fatty liver for the prevention of cardiovascular diseases. Hepatology 2010; 52: 1174–5.
  • Unger RH, Orci L. Lipotoxic diseases of nonadipose tissues in obesity. IntJ Obes Relat Metab Disord 2000; 24: 28-S32.
  • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007; 115: 3213-3223.
  • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol and obesity induced fatty liver diseases. Free Radic Biol Med 2008; 44: 1259–72.
  • Marra F. Nuclear factor-kappaB inhibition and non-alcoholic steatohepatitis: inflammation as a target for therapy. Gut 2008; 57: 570–2.
  • Mellor KM, Ritchie RH, Delbridge LM. Reactive oxygen cardiomyopathy. Clin Exp Pharmacol Physiol 2010; 37: 222–8.
  • McGavock JM, Victor RG, Unger RH, Szczepaniak LS. Adiposity of the heart, revisited. Ann Intern Med 2006; 144: 517–24.
  • Neubauer S. The failing heart an engine out of fuel. N Engl J Med 2007; 356: 1140–51.
  • Perseghin G, Lattuada G, De Cobelli F, Esposito A, Belloni E, Ntali G, Ragogna F, Canu T, Scifo P, Del Maschio A, Luzi L. Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. Hepatology 2008; 47: 51–8.
  • Szczeklik W, Sokolowska B, Mastalerz L, Miszalski-Jamka T, Musial J. Heart involvement detected by magnetic resonance in a patient with Churg-Strauss syndrome, mimicking severe asthma exacerbation. Allergy. 2010; 65: 1063–1064
  • Somberg JC, Molnar J. Usefulness of QT dispersion as an electrocardiographically derived index. Am J Cardiol 2002; 89: 291–294.

Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır

Year 2014, , 33 - 37, 01.01.2014

Ahmet Oğuz Baktır Bahadır Şarlı Ahmet Karaman Hüseyin Arınç Hayrettin Sağlam Hatice Karaman Abdülsamed Erden Yasemin Doğan

https://doi.org/10.5505/abantmedj.2014.00710

Abstract

AMAÇ: Alkole bağlı olmayan yağlı karaciğer hastalığı ile kardiyovasküler morbidite ve mortalite arasındaki ilişki hızla artmaktadır. QT dağılımı QTd ve düzeltilmiş QT dağılımı QTdz ventrikül repolarizasyonunun heterojenitesini göstermektedir. Çeşitli kardiyovasküler hastalığı olan ve olmayan gruplarda artmış QTd ve QTdz’nin artmış kardiyovasküler riski öngördüğü gösterilmiştir. Ancak kaynak araştırmamıza göre, alkole bağlı olmayan yağlı karaciğer hastalığında QTd ve QTdz incelenmemiştir. Alkole bağlı olmayan yağlı karaciğer hastalığında meydana gelen myokardiyal hasar ile repolarizasyonunun anormalliği arasında ilişki olabileceğini varsaydık.YÖNTEMLER: Gastroenteroloji polikliniğine başvurmuş ve alkole bağlı olmayan yağlı karaciğer hastalığı tespit edilmiş hastalar çalışmaya alındı.Yaş ve cinsiyet eşleşmesi yapılan sağlıklı kontrol bireyler ile QTd ve QTdz değerleri karşılaştırıldı.BULGULAR: Alkole bağlı olmayan yağlı karaciğer hastalığı tespit edilmiş hastalarda QTd 47.8±22.7 vs 22.5±7.5 ms, p

Keywords

QT dağılımı Alkole bağlı olmayan yağlı karaciğer hastalığı kardiyovasküler risk

References

  • Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E, Grimaldi A, Capron F, Poynard T. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898–906.
  • Bugianesi E. Nonalcoholic fatty liver disease (NAFLD) and cardiac lipotoxicity: Another piece of the puzzle. Hepatology 2008; 47: 2–4.
  • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009; 49: 306–17.
  • JC, Molnar J. Usefulness of QT dispersion as an electrocardiographically derived index. Am J Cardiol, 2002; 89: 291–29
  • Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 1994; 343: 327–329.
  • Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 2001; 26: 321-31
  • Sevimli S, Arslan S, Gündoğdu F. Carvedilol therapy is associated with improvement in QT dispersion in patients with congestive heart failure. Arch Turk Soc Cardiol 2007; 35:284-288.
  • Glancy JM, Garratt CJ, Woods KI, Bono DP. QT dispersion and mortality after myocardial infarction. Lancet 1995; 345: 945–948.
  • Zabel M, Woosly RL, Franz MR. Is dispersion of ventricular repolarisation rate dependent? PACE 1997; 20(Part I): 2405–2411.
  • Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369–75.
  • Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009; 106: 15430–5.
  • Salamone F, Bugianesi E. Nonalcoholic fatty liver disease: the hepatic trigger of the metabolic syndrome. J Hepatol 2011; 53: 1146–7.
  • Lautamäki R, Borra R, Iozzo P, Komu M, Lehtimäki T, Salmi M, Jalkanen S, Airaksinen KE, Knuuti J, Parkkola R, Nuutila P. Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. Am J Physiol Endocrinol Metab 2006; 291: 282–90.
  • Speliotes EK, Massaro JM, Hoffmann U, Vasan RS, Meigs JB, Sahani DV, Hirschhorn JN, O'Donnell CJ, Fox CS. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010; 51: 1979–87.
  • Salamone F, Galvano F, Li Volti G. Treating fatty liver for the prevention of cardiovascular diseases. Hepatology 2010; 52: 1174–5.
  • Unger RH, Orci L. Lipotoxic diseases of nonadipose tissues in obesity. IntJ Obes Relat Metab Disord 2000; 24: 28-S32.
  • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007; 115: 3213-3223.
  • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol and obesity induced fatty liver diseases. Free Radic Biol Med 2008; 44: 1259–72.
  • Marra F. Nuclear factor-kappaB inhibition and non-alcoholic steatohepatitis: inflammation as a target for therapy. Gut 2008; 57: 570–2.
  • Mellor KM, Ritchie RH, Delbridge LM. Reactive oxygen cardiomyopathy. Clin Exp Pharmacol Physiol 2010; 37: 222–8.
  • McGavock JM, Victor RG, Unger RH, Szczepaniak LS. Adiposity of the heart, revisited. Ann Intern Med 2006; 144: 517–24.
  • Neubauer S. The failing heart an engine out of fuel. N Engl J Med 2007; 356: 1140–51.
  • Perseghin G, Lattuada G, De Cobelli F, Esposito A, Belloni E, Ntali G, Ragogna F, Canu T, Scifo P, Del Maschio A, Luzi L. Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. Hepatology 2008; 47: 51–8.
  • Szczeklik W, Sokolowska B, Mastalerz L, Miszalski-Jamka T, Musial J. Heart involvement detected by magnetic resonance in a patient with Churg-Strauss syndrome, mimicking severe asthma exacerbation. Allergy. 2010; 65: 1063–1064
  • Somberg JC, Molnar J. Usefulness of QT dispersion as an electrocardiographically derived index. Am J Cardiol 2002; 89: 291–294.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ahmet Oğuz Baktır This is me

Bahadır Şarlı This is me

Ahmet Karaman This is me

Hüseyin Arınç This is me

Hayrettin Sağlam This is me

Hatice Karaman This is me

Abdülsamed Erden This is me

Yasemin Doğan This is me

Publication Date January 1, 2014
Published in Issue Year 2014

Cite

APA Baktır, A. O., Şarlı, B., Karaman, A., Arınç, H., et al. (2014). Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır. Abant Medical Journal, 3(1), 33-37. https://doi.org/10.5505/abantmedj.2014.00710
AMA Baktır AO, Şarlı B, Karaman A, Arınç H, Sağlam H, Karaman H, Erden A, Doğan Y. Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır. Abant Med J. January 2014;3(1):33-37. doi:10.5505/abantmedj.2014.00710
Chicago Baktır, Ahmet Oğuz, Bahadır Şarlı, Ahmet Karaman, Hüseyin Arınç, Hayrettin Sağlam, Hatice Karaman, Abdülsamed Erden, and Yasemin Doğan. “Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır”. Abant Medical Journal 3, no. 1 (January 2014): 33-37. https://doi.org/10.5505/abantmedj.2014.00710.
EndNote Baktır AO, Şarlı B, Karaman A, Arınç H, Sağlam H, Karaman H, Erden A, Doğan Y (January 1, 2014) Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır. Abant Medical Journal 3 1 33–37.
IEEE A. O. Baktır, B. Şarlı, A. Karaman, H. Arınç, H. Sağlam, H. Karaman, A. Erden, and Y. Doğan, “Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır”, Abant Med J, vol. 3, no. 1, pp. 33–37, 2014, doi: 10.5505/abantmedj.2014.00710.
ISNAD Baktır, Ahmet Oğuz et al. “Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır”. Abant Medical Journal 3/1 (January 2014), 33-37. https://doi.org/10.5505/abantmedj.2014.00710.
JAMA Baktır AO, Şarlı B, Karaman A, Arınç H, Sağlam H, Karaman H, Erden A, Doğan Y. Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır. Abant Med J. 2014;3:33–37.
MLA Baktır, Ahmet Oğuz et al. “Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır”. Abant Medical Journal, vol. 3, no. 1, 2014, pp. 33-37, doi:10.5505/abantmedj.2014.00710.
Vancouver Baktır AO, Şarlı B, Karaman A, Arınç H, Sağlam H, Karaman H, Erden A, Doğan Y. Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır. Abant Med J. 2014;3(1):33-7.