Abstract
Hypothyroidism is a common endocrine disorder. With the exception of certain conditions, the treatment of hypothyroidism levothyroxine. Daily average dose of the levothyroxine is 1.6 mcg/kg. Levothyroxine intoxication is a rare condition and it occurs more often in children. The toxication of levothyroxine in adults is usually asymptomatic. In this paper we report a 24-year-old man who attempted suicide with large amounts of levothyroxine. Diagnosing depends on history, physical examination and laboratory findings. Medical treatment includes antithyroid drugs, steroids, betablockers and drugs to prevent gastrointestinal absorption activated charcoal, cholestyramine . In follow-up close monitoritation is needed and should be at least 5-7 days
Keywords
References
- Beier C, Liebezeit B, Völkl TM, Zimdars K, Dörr HG. Attempted suicide with L-thyroxine in an adolescent girl. Klin Padiatr 2006; 218: 34-7.
- Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J. Section II. Drugs. Part D. Systems Toxicology. In: Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J (Eds): Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Pennsylvania: Williams& Wilkins 1997: 242-4.
- Luis D.A, Duenas A, Martin J, Abad L, Cuellara L, Aller R. Light Symptoms following a High-Dose Intentional L Thyroxine Ingestion Treated with Cholestyramine. Horm Res 2002; 57: 61-63.
- Litovitz TL, White JD. Levothyroxine ingestion in children: an analysis of 78 cases. Am J Emerg Med 1985; 3: 297.
- Lehrner LM, Weir MR. Acute ingestion of thyroid hormones. Pediatrics 1984; 73: 313.
- Hiassa Y, Ishida T, Aihara T, et al. Acute myocardial infarction due to coronary spasm associated with L- thyroxine therapy. Clin Cardiol 1989; 12: 161.
- Lewander WJ, Lacouture PG, Silva JE, Lovejoy FH. Acute thyroxine ingestion in pediatric patients. Pediatrics 1989; 84: 262.
- Shilo L, Kovatz S, Hadari R, Weiss E, Nabriski D, Shenkman L. Massive thyroid hormone overdose: Kinetics, clinical manifestations and management. Isr Med Assoc J 2002; 4: 298-299.
Abstract
Hipotiroidizm sık görülen bir endokrin hastalıktır. Nadir görülen durumlar dışında, hipotiroidizmin tedavisi ömür boyu levotiroksin tedavisi gerektirir. Levotiroksinin günlük dozu ortalama olarak 1,6 mcg/kg’dır. Levotiroksin intoksikasyonu nadir görülen bir tablodur ve çocuklarda daha sıktır. Erişkinlerde genellikle asemptomatik seyreder. Burada suisid amacıyla çok miktarda levotiroksin almış 24 yaşında erkek hastayı sunduk. Levotiroksin intoksikasyonu tanısı hikaye, fizik muayene ve laboratuar bulguları ile konulur. Medikal tedavi antitiroid ilaçları, steroidleri, beta blokerleri ve gastrointestinal emilimi engelleyen ilaçları aktif kömür, kolestramin içerir. Takip süresince yakın monitorizasyon gereklidir ve takip en az 5-7 gün olmalıdır
References
- Beier C, Liebezeit B, Völkl TM, Zimdars K, Dörr HG. Attempted suicide with L-thyroxine in an adolescent girl. Klin Padiatr 2006; 218: 34-7.
- Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J. Section II. Drugs. Part D. Systems Toxicology. In: Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J (Eds): Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Pennsylvania: Williams& Wilkins 1997: 242-4.
- Luis D.A, Duenas A, Martin J, Abad L, Cuellara L, Aller R. Light Symptoms following a High-Dose Intentional L Thyroxine Ingestion Treated with Cholestyramine. Horm Res 2002; 57: 61-63.
- Litovitz TL, White JD. Levothyroxine ingestion in children: an analysis of 78 cases. Am J Emerg Med 1985; 3: 297.
- Lehrner LM, Weir MR. Acute ingestion of thyroid hormones. Pediatrics 1984; 73: 313.
- Hiassa Y, Ishida T, Aihara T, et al. Acute myocardial infarction due to coronary spasm associated with L- thyroxine therapy. Clin Cardiol 1989; 12: 161.
- Lewander WJ, Lacouture PG, Silva JE, Lovejoy FH. Acute thyroxine ingestion in pediatric patients. Pediatrics 1989; 84: 262.
- Shilo L, Kovatz S, Hadari R, Weiss E, Nabriski D, Shenkman L. Massive thyroid hormone overdose: Kinetics, clinical manifestations and management. Isr Med Assoc J 2002; 4: 298-299.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | September 1, 2013 |
| Published in Issue | Year 2013 |