Metabolic syndrome and Gender Difference: Tissue Doppler Study

Year 2012, , 39 - 44, 01.05.2012

Göktürk İpek Emine Bilen Mustafa Kurt Mehmet Fatih Karakaş Uğur Arslantaş İsa Öner Yüksel Ayşe Saatci Yaşar Mehmet Bilge

https://doi.org/10.5505/abantmedj.2012.35744

Abstract

OBJECTIVE: Metabolic syndrome MS is a cluster of cardiovascular risk factors. Gender difference has different effects on cardiac functions in MS and this has been thought to be decisive in terms of interference. In this study, we aimed to investigate the effect gender differences MS patients with tissue Doppler echocardiography. METHODS: The study population consisted of 83 females and 87 males with the diagnosis of MS. All the study population underwent a detailed echocardiography with tissue Doppler parameters of systolic myocardial velocity Sm , early diastolic velocity Em and late diastolic velocity Am were measured from septal, lateral, and right ventricular annulus. Myocardial performance index MPI was calculated by dividing the sum of isovolumetric relaxation and isovolumetric contractine times by ejection time. RESULTS: While there were no significant differences in early and late diastolic velocities, septal, lateral Sm measurements and septal MPI were significantly higher in men than in women p values: 0,007, 0,001 and 0,027 respectively . Right ventricle and lateral MPI were comparable between study groups. Besides septal and lateral ejection times were significantly higher in men when compared to women p values: 0,016 and 0,012 respectively . CONCLUSION: Cardiac functions in patients with metabolic syndrome differ between the sexes. The different effect of MS on sexes is important in the development of patient-oriented treatment strategies in terms of improving the treatment of coronary artery disease and risk factors.

Keywords

Metabolic syndrome, gender, tissue doppler

Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması

Abstract

AMAÇ: Metabolik sendrom MS kardiyak fonksiyonlar üzerine zararlı etkileri olan risk faktörleri kümesidir. Cinsiyet farkının metabolik sendromun kardiyak fonksiyonlar üzerinde farklı etkileri olduğu ve daha fazla etkilenme açısından belirleyici olduğu düşünülmektedir. Biz bu çalışmamızda MS hastalarında cinsiyet farkının kardiyak fonksiyonlar üzerine olan etkisini doku Doppler tekniği kullanarak araştırmayı amaçladıkYÖNTEMLER: Çalışmaya MS tanısı konan 83 kadın ve 87 erkek hasta alınmıştır. Bu hastalara ayrıntılı transtorasik ekokardiyografi yapılarak doku Doppler parametreleri olan sistolik miyokardiyal hız Sm , erken diyastolik hız Em ve geç diyastolik hız Am , septal, lateral ve sağ ventrikül bölgelerinden ölçüldü. Miyokard performans indeksi MPİ isovolümetrik kontraksiyon ve relaksasyon zamanlarının toplamının aortik ejeksiyon zamanına oranı olarak hesaplandı.BULGULAR: Erken ve geç diyastolik hızlarda fark saptanmazken septal, lateral Sm değerleri ve septal MPI erkeklerde kadınlara göre anlamlı şekilde yüksek saptandı p değeri sırasıyla 0,007, 0,001 ve 0,027 Sağ ventrikül ve lateral MPI değerlerinde fark saptanmadı. Ayrıca septal ve lateral ejeksiyon zamanı değerleri erkeklerde anlamlı şekilde yüksek saptandı p değeri sırasıyla 0,016 ve 0,012 . SONUÇ: Metabolik sendromlu hastalarda kardiyak fonksiyonlar cinsiyetler arasında farklılık göstermektedir. Metabolik sendromun farklı cinsiyetlerde etkisinin farklı olması, birey odaklı tedavi stratejileri geliştirmek açısından değerlendirildiğinde koroner arter hastalığı ve risk faktörlerinin tedavisinde farklı yaklaşımlar geliştirilmesinde önemlidir.

Keywords

Metabolik sendrom, cinsiyet, doku doppler

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