The relationship between serum biochemical parameters and glycemic control in diabetes

Year 2012, , 51 - 54, 01.05.2012

Kübranur Karatoprak Sema Uysal Zeynep Seçkin Akkılık Müjgan Ercan Fatma Meriç Yılmaz

https://doi.org/10.5505/abantmedj.2012.36854

Abstract

OBJECTIVE: We aimed this study to evaluate the relationship between some biochemical parameters and glycemic control in diabetic patients categorized by HbA1c levels.METHODS: This study includes 24 good glycaemic control HbA1c6,5 patients with diabetes mellitus and 29 healthy subjects. Plazma levels of HbA1c measured by HPLC. Serum fasting and post-prandial glucose, creatinin, triglyceride, total cholesterol, HDL cholesterol concentrations analyzed by photometric methods. Urine protein and microalbumin levels studied by turbidimetric method. Serum TSH, sT3, sT4, vitamin B12 and folic acid concentrations measured by electrochemiluminescent assay.RESULTS: Serum triglyceride levels of poorly glycemic control group were higher than healthy subjects p=0,003 . Urine microalbumin/creatinine ratio was increased in patients with poorly glycemic control when compared good glycaemic control group p=0,05 . There was no significant differences between groups and other biochemical parameters. CONCLUSION: The triglyceride and microalbumin levels were associated with glycemic control in diabetic patients. These data suggested that glycemic control may affect development of nephropathy and coronary artery disease in patients with diabetes mellitus.

Keywords

Glycaemic control, diabetes mellitus, HbA1c, lipid parameters, microalbumin

Diyabette glisemik kontrolün serum biyokimyasal parametreleri ile ilişkisi

Abstract

AMAÇ: Bu çalışmanın amacı diyabetes mellitus hastalarını HbA1c düzeylerine göre iyi ve kötü kontrollü diyabet olarak sınıflandırarak glisemik kontrol ile bazı biyokimyasal parametrelerin ilişkisini araştırmaktır.YÖNTEMLER: Çalışmaya 24 iyi kontrollü diyabet HbA1c6,5 hastası ve diyabeti olmayan 29 sağlıklı birey katıldı. HbA1c seviyeleri HPLC yöntemiyle, açlık ve tokluk kan glukozu, kreatinin, trigliserid, total kolesterol ve HDL kolesterol seviyeleri fotometrik, idrar protein ve mikroalbumin düzeyleri türbidimetrik, TSH, sT3, sT4, B12 vitamini ve folik asit seviyeleri elektrokemilüminesans yöntemle ölçüldü.BULGULAR: Kötü kontrollü diyabet hastalarının trigliserid düzeyleri kontrol gurubuna göre anlamlı derecede yüksek bulundu p=0,003 . İdrar mikroalbumin/kreatinin düzeyleri, kötü kontrollü diyabet hastalarında iyi kontrollü diyabet hastalarına göre anlamlı şekilde yüksek bulundu p=0,05 . Diğer parametreler açısından, gruplar arasında anlamlı bir farklılık tespit edilemedi. SONUÇ: Diyabetik hastalarda glisemik kontrol, trigliserid ve mikroalbumin düzeyi ile ilişkili bulunmuştur. Bu veriler, diyabetli hastalarda glisemik kontrolün nefropati ve koroner kalp hastalığı gelişimini etkileyebileceğini düşündürmektedir.

Keywords

Glisemik kontrol, diyabetes mellitus, HbA1c, lipid profili, mikroalbumin

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