Hemodiyaliz Hastalarında Sinakalsetin Serum Kalsiyum, Fosfor, ve Paratiroid Hormon Düzeylerine Etkisi

Year 2012, , 55 - 60, 01.05.2012

Erkan Şengül Selma Satılmışoğlu Aysun Şengül Sevim Dindar

https://doi.org/10.5505/abantmedj.2012.03522

Abstract

Bu çalışmanın amacı hemodiyaliz hastalarında sinakalset kullanımının serum kalsiyum, fosfor ve paratiroid hormon üzerideki etkisini incelemektir. YÖNTEMLER: Çalışma, 15 9 E, 6 K hemodiyaliz hastasında yapıldı. 3 ay süre ile sinakalset kullanan hastaların retrospektif olarak dosyaları incelendi. Biyokimya tetkikleri ve kan basıncı kayıtları kaydedildi. İstatistiksel analizler SPSS ver. 15 ile gerçekleştirildi.BULGULAR: Serum kalsiyum, kalsiyum x fosfor ürünü ve paratiroid hormon düzeylerinde istatistiksel olarak anlamlı azalmalar saptandı sırasıyla P=0.001, P=0.04 ve P=0.009 . Fosfor düzeyi azalmakla birlikte farklılık istatistiksel olarak anlamlı bulunmadı. Üç hastada bulantı, üç hastada ise bulantı ve kusma gözlendi. Ayrıca üç hastada kalsiyum seviyesi 8 mg/dl’nin altına düştü. SONUÇ: Sinakalset hemodiyaliz hastalarında serum kalsiyum, kalsiyum x fosfor ürünü ve paratiroid hormon düzeylerini anlamlı olarak azaltmaktadır. Tedavi sırasında bulantı, kusma ve hipokalsemi sık görülmektedir. Ancak, daha fazla hasta üzerinde yapılacak çalışmalara ihtiyaç vardır.

Keywords

Hiperparatiroidizm, sinakalset, hemodiyaliz

The effect of Cinacalcet on Serum Calcium, Phosphorus and Parathyroid Hormone in Hemodialysis Patients

Abstract

The purpose of this study is to examine the effect of cinacalcet on serum calcium, phosphorus, and parathyroid hormone in hemodialysis patients.METHODS: This study was performed in 15 hemodialysis patients. The medical records of patients taking cinacalcet for three months were examined. Biochemical tests and blood pressure were recorded. The statistical analysis was performed using SPSS version 15.0. P< 0.05 was considered statistically significant. RESULTS: There were statistically significant decreases in calcium, calcium x phosphorus product and parathyroid hormone levels P=0.001, P=0.04 and P=0.009 respectively . Phosphorus level was reduced but not significantly. Nausea was observed in three patients, nausea and vomiting in three patients, as well as hypocalcaemia

Keywords

Hyperparathyroidism, cinacalcet, hemodialysis

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