Meme Kanserinde ADC Değerleri ile Histopatolojik Prognostik Faktörler Arasındaki İlişkinin Değerlendirilmesi

Year 2021, Volume: 10 Issue: 1, 7 - 17, 30.04.2021

Esra Ümmühan Mermi Yetiş , Rahmi Çubuk , Ahmet Midi , Levent Çelik

https://doi.org/10.47493/abantmedj.2021.27

Abstract

Amaç: Meme kanserinde difüzyon MR, lezyonun morfolojisi yanında, metabolik aktivitesi hakkında da bilgi vermektedir. Patolojik prognostik faktörler meme kanserli olgularda tedavi protokolünü ve sağ kalımı etkilemektedir. Bu çalışmada amacımız, meme kanserli olgularda ADC değerleri ile patolojik prognostik faktörler arasında ilişkinin değerlendirilmesidir.
Gereç ve Yöntemler: Kliniğimizde, meme kanseri tanısı ile preoperatif olarak Meme MR tetkiki yapılan 33 olgu retrospektif olarak değerlendirildi.33 olguda toplam 44 malign kitle vardı. Tüm olguların post-operatif patoloji sonuçları elde edildi. Post-op histopatolojik spesmenlerde tümor çapı, aksiler lenf nodu durumu, histolojik grade klasik prognostik faktörler olarak ve östrojen reseptör durumu, progesteron reseptör durumu moleküler prognostik faktörler olarak değerlendirilmiştir. Difüzyon meme MR özellikleri ile klasik ve moleküler histopatolojik prognostik faktörler arasındaki ilişki Mann Whitney U test, Kruskal Wallis test and Spearman korelasyon analizi kullanılarak değerlendirildi.
Bulgular: ADC değerleri, aksiller lenf nodu tutulumu 3’den az olan olgularda (N1) aksiller lenf nodu tutulumu 4 ve/veya daha fazla olan olgulara (N2-N3) göre anlamlı düzeyde yüksek bulundu (p=0,011; p=0,010; p<0,05).
Sonuç: Düşük ADC değerleri lenf nodu tutulumuyla ilişkiliydi.

Keywords

Difüzyon, Meme Kanseri, Manyetik Rezonans Görüntüleme

Project Number

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Relationship Between ADC Values and Histopathological Prognostic Factors in Breast Cancer

Abstract

Objective
To evaluate the relationship between ADC values and histopthological prognostic factors in breast cancer patients.
Materials and Methods
A total of 33 female breast cancer patients with preoperative breast MRI image were retrospectively evaluated. There were a total of 44 malignant masses in 33 patients.
In postoperative evaluation of histopathological specimens, conventional prognostic factors used were the tumor diameter , axillary lymph nodes and histological grade, and the molecular prognostic factors used were estrogen and progesterone receptor expression, C-erb-B2. In diffusion MR with a b-value of 1000s/mm² and 1500 s/mm², the relationship between apparent diffusion coefficient(ADC) and conventional and molecular histopathological prognostic factors was evaluated by using statistical methods such as Mann Whitney U test, Kruskal Wallis test and Spearman correlation analysis.
Results
ADC was significiantly lower in patients with 4 and/ormore axillary lymph nodes involvement (N2-N3) compared to those with <3 axillary lymph nodes involvement (p=0.011;p=0.010;p<0.05).
Conclusion
Lower ADC values are related with axillary lymph node involvement.

Keywords

Breast Neoplasm, Diffussion, Prognosis

Supporting Institution

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Project Number

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