Zihinsel engelli bireylerde Demodex akar (Acari: Demodecidae) prevalansı ve yoğunluğu

Year 2023, Volume: 5 Issue: 2, 87 - 93, 31.07.2023

Erhan Zeytun , Sibel Doğan , Engin Doğaner

https://doi.org/10.47121/acarolstud.1328108

Abstract

Bu çalışma Erzincan ilindeki rehabilitasyon merkezlerinde bakım ve destek hizmeti almakta olan zihinsel engelli bireylerde D. folliculorum ve D. brevis prevalansı ve yoğunluğunu belirlemek amacıyla yapılmıştır. Çalışmaya Erzincan il merkezinde faaliyet gösteren 7 ayrı rehabilitasyon merkezinde bakım ve destek hizmeti almakta olan 217 zihinsel engelli katılımcı dahil edildi. Örnek materyalleri her bir katılımcının yanak, nazolabial ve çene bölgesinden Standart Yüzeyel Deri Biyopsisi (SYDB) yöntemi ile alındı ve ışık mikroskobunda Demodex akar varlığı ve sayısı bakımından incelendi. Çalışmada zihinsel engellilerin %58’inde D. folliculorum (ortalama 8,34/cm2), %25’inde D. brevis (ortalama 1,26/cm2) olmak üzere toplam %61’inde Demodex akar (ortalama 9,59/cm2) tespit edildi. Katılımcılar Demodex prevalansı bakımından değerlendirildiğinde D. folliculorum’un D.brevis’e göre yaklaşık 2,3 kat daha yaygın olduğu belirlendi. Benzer şekilde cm2’deki ortalama akar sayısı bakımından değerlendirildiğinde D. folliculorum’un, D. brevis’ten yaklaşık 7 kat daha yoğun olduğu tespit edildi. Diğer taraftan zihinsel engel şiddeti arttıkça Demodex akar prevalansının arttığı belirlenirken, Demodex yoğunluğunun en fazla orta düzey zihinsel engele sahip katılımcılarda olduğu tespit edildi. Sonuç olarak gerek sağlıklı bireylerde gerek birçok hasta grubunda olduğu gibi zihinsel engelli bireylerde de D. folliculorum ve D. brevis’in yaygın ve yoğun olduğu tespit edildi. Çalışmamızda elde edilen bulguların dermatolojik şikayetleri olan zihinsel engelli bireylerin klinik değerlendirme sürecinde göz önünde bulundurulmasının faydalı olabileceği düşünüldü.

Keywords

Demodex, epidemiyoloji, Erzincan, mental retardasyon

Supporting Institution

Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

Proje No: SAĞ-A-080715-0156

Thanks

Çalışmayı destekleyen Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimine (Proje No: SAĞ-A-080715-0156), Erzincan Binali Yıldırım Üniversitesi Etik Kurul Başkanlığına (Karar No: 2015-01/6), Erzincan Aile ve Sosyal Politikalar İl Müdürlüğüne, Erzincan İl Milli Eğitim Müdürlüğüne, Prof. Dr. Salih Doğan’a, Doç. Dr. Yücel Karakurt’a, Dr. Öğr. Üyesi Mustafa Yazıcı’ya, çalışmanın yürütüldüğü Rehabilitasyon Merkezi yönetici ve çalışanlarına ve tüm katılımcılara teşekkür ederiz.

Prevalence and density of Demodex mites (Acari: Demodecidae) in mentally disabled individuals

Abstract

This study was conducted to determine the prevalence and intensity of D. folliculorum and D. brevis in mentally disabled individuals receiving care and support services in rehabilitation centers in Erzincan province. The study included 217 mentally disabled participants who were receiving care and support services in 7 separate rehabilitation centers operating in the provincial center of Erzincan. Sample materials were taken from the cheek, nasolabial and chin area of each participant by Standard Superficial Skin Biopsy (SSSB) method and examined for the presence and number of Demodex mites under a light microscope. In the study, D. folliculorum (mean 8.34/cm2) was detected in 58% of mentally disabled people, D. brevis (mean 1.26/cm2) in 25%, and Demodex mites (mean 9.59/cm2) was detected in 61% of the all participants. When the participants were evaluated in terms of Demodex prevalence, it was determined that D. folliculorum was approximately 2.3 times more common than D. brevis. Similarly, when evaluated in terms of the average number of mites per cm2, it was found that D. folliculorum was about 7 times denser than D. brevis. On the other hand, it was determined that the prevalence of Demodex mites increased as the severity of intellectual disabilities increased, while it was found that the intensity of Demodex was highest in participants with moderate mentally disabled. As a result, it was found that D. folliculorum and D. brevis were widespread and intense in both healthy individuals and mentally disabled individuals, as well as in many patient groups. It was thought that the findings obtained in our study might be useful to consider mentally disabled individuals with dermatological complaints during the clinical evaluation process.

Keywords

Demodex, epidemiology, Erzincan, mental retardation

Project Number

Proje No: SAĞ-A-080715-0156

References

• Benk Silfeler, D., Keskin Kurt, R., Aycan Kaya, Ö., Yengil, E., Hamamcı, B., Okyay, A.G. and Beyazıt, A. 2015. Demodex folliculorum in polycystic ovary syndrome patients. European Review for Medical and Pharmacological Sciences, 19: 1141-1145.
• Casas, C., Paul, C., Lahfa, M., Livideanu, B., Lejeune, O., Alvarez-Georges, S., Saint-Martory, C., Degouy, A., Mengeaud, V., Ginisty, H., Durbise, E., Schmitt, A. M. and Redoules, D. 2012. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Experimental Dermatology, 21: 906-910. doi: 10.1111/exd.12030
• Çiftci, İ.H., Dündar, U., Cetinkaya, Z., Kulaş, M., Kıyıldı, N., Türel, A., Evcik, D. and Kavuncu, V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52 (1): 70-73. doi: 10.2478/s11686-007-0002-7
• Desch, C.E. and Nutting, W.B. 1972. Demodex folliculorum (Simon) and D. brevis Akbulatova of man: redescription and reevaluation. The Journal of Parasitology, 58 (1): 169-177. doi: 10.2307/3278267
• Desch, C.E. and Nutting, W.B. 1977. Morphology and functional anatomy of Demodex folliculorum (Simon) of man. Acarologia, 19 (3): 422-462.
• Dolenc-Voljc, M., Pohar, M. and Tomaz, L. 2005. Density of Demodex folliculorum in perioral dermatitis. Acta Dermato Venereologica, 85: 211-215. doi: 10.1080/00015550510030069
• Durmaz, S., Yula, E., Aycan-Kaya, Ö., Aksoy-Gökmen, A., Kılınç, C., Atambay, M., Ekiz, O., Gözükara-Bağ, H. and Pektaş, B. 2015. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behçet’s disease. Biomedical Research, 26 (3): 549-555.
• Düzgün, Ö.Y. and Aytekin, S. 2007. Comparison of Demodex folliculorum density in haemodialysis patients with a control group. Journal of the European Academy of Dermatology and Venereology, 21: 480-483. doi: 10.1111/j.1468-3083.2007.01926.x
• El-Bassiouni, S.O., Ahmed, J.A., Younis, A.I., Ismail, M.A., Saadawi, A.N. and Bassiouni, S.O. 2005. A study on Demodex folliculorum mite density and immune response in patients with facial dermatoses. Journal of the Egyptian Society of Parasitology, 35 (3): 899-910.
• Erbağcı, Z. and Özgöztaşı, O. 1998. The significance of Demodex folliculorum density in rosacea. International Journal of Dermatology, 37 (6): 421-425. doi: 10.1046/j.1365-4362.1998.00218.x
• Fırat, P.Y., Geçit, İ., Depecik, F., Karadan, M., Karcı, E., Karaman, Ü. and Çalık, S. 2010. Demodex spp. positivity among laboratory staff, kitchen staff, cleaning workers and nurses working in a state hospital Türkiye Parazitoloji Dergisi, 34: 164-167. [In Turkish] doi: 10.5152/tpd.2010.05
• Georgala, S., Katoulis, A.C., Kylafis, G.D. Koumantaki-Mathioudaki, E., Georgala, C. and Aroni, K. 2001. Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. Journal of the European Academy of dermatology and Venereology, 15: 441-444. doi: 10.1046/j.1468-3083.2001.00331.x
• Hana, A.G., de la Garza, C.M., Arenas, L.V., Guerrero, C.G. and Gonzalez, S.E. 2004. Prevalence of Demodex folliculorum and Demodex brevis in a Mexican population. Medicina Universitaria, 6 (23): 96-100.
• Isa, N.H.M., Loong, L.W., Fang, G.H., Mohamad, A.M., Razali, N., Rani, N.R., Abd Manap, S.N.A. and Abdullah, S.R. 2011. Demodicosis among university medical students in Malaysia and the effects of facial cleanser and moisturizer usage. Southeast Asian Journal of Tropical Medicine and Public Health, 42 (6): 1375-1380.
• Kaplan, M., Keleştemur, N. and Başpınar, S. 2012. Demodex spp. prevalence among university students. Kafkas Üniversitesi Veterinerlik Fakültesi Dergisi, 18: 43-46. doi: 10.9775/kvfd.2011.5970
• Karakurt, Y. and Zeytun, E. 2018. Evaluation of the efficacy of tea tree oil on the density of Demodex mites (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis. Journal of Parasitology, 104 (5): 473-478. doi: 10.1645/18-46
• Karaman, Ü., Kolören, Z., Enginyurt, Ö. and Özer, A. 2014. The epidemiology of Demodex mites at the college students living in dormitories in the city of Ordu. Türkiye Parazitoloji Dergisi, 38: 166-171. [In Turkish] doi: 10.5152/tpd.2014.3517
• Karıncaoğlu, Y., Esrefoğlu Seyhan, M., Bayram, N., Aycan, Ö. and Taşkapan, H. 2005. Incidence of Demodex folliculorum in patients with end stage chronic renal failure. Renal Failure, 27: 495-499. doi: 10.1080/08860220500198037
• Kokaçya, M.H., Yengil, E., Aycan Kaya, Ö. and Şahpolat, M. 2014. The frequency of Demodex spp. in depression patients. Erciyes Medical, 36 (4): 166-169.
• Kulaç, M., Çiftci, İ.H., Karaca, S. and Çetinkaya, Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal of Dermatology, 47: 72-77. doi: 10.1111/j.1365-4632.2007.03336.x
• Kömerik, N., Kırzıoğlu, Z. and Efeoğlu, CG. 2012. Oral health of mentally retarded individuals. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 22 (1): 96-104. [In Turkish]
• Miman, Ö., Şimşek, K., Özselçuk, S., Küçükkoçak, E. and Karaca, Ş. 2008. Investigation of Demodex sp. using cellophane tape method among university students. Kocatepe Tıp Dergisi, 9: 37-39. [In Turkish]
• Okyay, P., Ertabaklar, H., Savk, E. and Ertuğ, S. 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. Journal of European Academy of Dermatology and Venereology, 20 (4): 474-476. doi: 10.1111/j.1468-3083.2006.01470.x
• Özçelik, S., Sümer, Z., Değerli, S., Özyazıcı, G., Berksoy Hayta, S., Akyol, M. and Candan, F. 2007. The incidence of Demodex folliculorum in patients with chronic kidney deficiency. Türkiye Parazitoloji Dergisi, 31 (1): 66-68. [In Turkish]
• Özdemir, H., Özer, E., Özdemir, S. and Alkanat, M. 2015. The prevalance of Demodex species in faculty of health science students. Türkderm - Archives of the Turkish Dermatology and Venerology, 49: 139-141. doi: 10.4274/turkderm.72558
• Rios-Yuil, J.M. and Mercadillo-Perez, P. 2013. Evaluation of Demodex folliculorum as a risk factor for the diagnosis of rosacea in skin biopsies. Mexico's General Hospital (1975-2010). Indian Journal of Dermatology, 58: 157. doi: 10.4103/0019-5154.108069
• Roihu, T. and Kariniemi, A.L. 1998. Demodex mites in acne rosacea. Journal of Cutaneous Pathology, 25 (10): 550-552. doi: 10.1111/j.1600-0560.1998.tb01739.x
• Rufli, T. and Mumcuoglu, Y. 1981. The hair follicle mites D. folliculorum and D. brevis: biology and medical importance. Dermatology, 162: 1-11. doi: 10.1159/000250228
• Sarı, Y., Zeytun, E., Doğan, S. and Karakurt, Y. 2019. The prevalence and intensity of Demodex folliculorum and D. brevis (Acari: Demodicidae) in patients with ocular dandruff. Acarological Studies, 1 (1): 23-43. [In Turkish]
• Sönmez, Ö., Yalçın, Z.G., Karakeçe, E., Çiftci, İ.H. and Erdem, T. 2013. Associations between Demodex species infestation and various types of cancer. Acta Parasitologica, 58 (4): 551-555. doi: 10.2478/s11686-013-0178-y
• Talghini, S., Fouladi, D.F., Babaeinejad, S., Shenasi, R. and Samani, S.M. 2015. Demodex mite, rosacea and skin melanoma; coincidence or association? Türkiye Parazitoloji Dergisi, 39: 41-46. doi: 10.5152/tpd.2015.3473
• Tilki, E., Zeytun, E. and Doğan, S. 2017. Prevalence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Erzincan province. Turkish Journal of Parasitology, 41 (2): 80-86. [In Turkish] doi: 10.5152/tpd.2017.5156
• Yazar, S., Özcan, H. and Çetinkaya, Ü. 2008. Investigation of Demodex sp. using cellophane tape method among university students. Türkiye Parazitoloji Dergisi, 32 (3): 238-240. [In Turkish]
• Zeytun, E. 2017. Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: a cross-sectional study. Turkish Journal of Geriatrics, 20 (2): 142-150.
• Zeytun, E. and Ölmez, H. 2017. Demodex (Acari: Demodicidae) infestation in patients with KOAH, and the association with immunosuppression. Erzincan University Journal of Science and Technology, 10 (2): 220-231. [In Turkish]
• Zeytun, E. and Karakurt, Y. 2019. Prevalence and load of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with chronic blepharitis in the Province of Erzincan, Turkey. Journal of Medical Entomology, 56 (1), 2-9. doi: 10.1093/jme/tjy143
• Zeytun, E and Yazıcı, M. 2019. Incidence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with acne in the province of Erzincan, Turkey. International Journal of Acarology, 45 (3): 108-112.
• Zeytun, E and Yazıcı, M. 2022. Prevalence and density of Demodex mites (Acari: Demodecidae) in patients with seborrheic dermatitis. Acarological Studies, 4 (2): 54-60. doi: 10.47121/acarolstud.1101631
• Zeytun, E., Tilki, E., Doğan, S. and Mumcuoglu, K.Y. 2017. The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. International Journal of Dermatology, 56 (7): 762-766. doi: 10.1111/ijd.13600
• Zhao, Y.E., Guo, N., Xun, M., Xu, J.R., Wang, M. and Wang, D.L. 2011. Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae). Journal of Zhejiang University - Science B, 12 (12): 998-1007. doi: 10.1631/jzus.B1100079