Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Year 2020, Volume: 5 Issue: 2, 48 - 51, 31.08.2020

Mikail Çakır Doğan Yıldırım Okan Murat Aktürk , Oğuzhan Sunamak , Turgut Dönmez , Busra Ekinci Bickici , Fazilet Erözgen

https://doi.org/10.25000/acem.637992

Abstract

Aim: Axillary status evaluation and, if present, the number of metastatic lymph nodes is important in staging and adjuvant therapy planning of breast cancer. A number of clinical and pathological variables were analyzed to detect factors affecting nodal status. Methods: A total of 298 women with unilateral breast cancer operated with axillary lymph node dissection or sentinel lymph node biopsy, were retrospectively analyzed for age, localization, BIRADS category, pathological features, subtypes as Luminal A, Luminal B, HER2 positive, triple negative, Ki-67 index and number of lymph nodes involved. Results: The mean age was 54.7 years. BIRADS 5 was the most detected category in 208 (69.8%) patients. The most common pathological type was invasive ductal carcinoma in 265 patients (88.9%). The most detected tumor grade was grade 2 in 160 (31.2%). Luminal B was the most common subtype and detected in 173 patients (58.1%). Ki-67 indexes were detected between 0-14% in 69 patients (23.3%), between 15-19% in 31patients (10.4%) and above 20% in 198 patients (66.4%). Conclusions: HER2 positivity, Ki-67 index,>

Keywords

breast cancer, axillary lymph node metastasis, hormonal status

Meme kanserinin aksiller metastazlarında ER, PR, HER2 ve Ki-67 indeksinin etkisi

Abstract

Amaç: Aksiller lenf nodu metastazı değerlendirmesi ve varsa lenf nodu sayısı meme kanserinin evrelemesi ve adjuvan tedavi planlamasında önemlidir. Amacımız lenf nodu metastazını etkileyen faktörleri saptamak için bir dizi klinik ve patolojik değişkeni araştırmaktır. Yöntemler: Aksiller lenf nodu diseksiyonu veya sentinel lenf nodu biyopsisi ile opere edilen tek taraflı meme kanseri olan 298 kadın hastanın yaş, lokalizasyon, BIRADS kategorisi, patolojik özellikler, Luminal A, Luminal B, HER2 pozitif, tripl negatif subtipleri, Ki-67 indeksi verileri ile metastatik lenf nodu sayısı arasındaki ilişkisi analiz edildi. Bulgular: Yaş ortalaması 54,7 yıl idi. BIRADS 5, 208 (% 69,8) hastada en fazla saptanan kategori idi. En sık görülen patolojik tip 265 hastada (% 88,9) invaziv duktal karsinomdu. En fazla saptanan tümör evresi 2 olup, 160 hastada (% 31,2) tespit edildi. Luminal B en sık görülen subtipti ve 173 (% 58,1) hastada tespit edildi. Ki-67 indeksi 69 hastada (% 23,3) % 0-14, 31 hastada (% 10,4) % 15-19 ve 198 hastada (% 66,4) % 20'nin üzerinde saptandı. Sonuçlar: HER2 pozitifliği, Ki-67 indeksi ve progesteron reseptör negatifliği aksiller lenf nodu metastazını etkileyen en önemli faktörlerdir.

Keywords

meme kanseri, aksiller lenf nodu metastazı, hormonal durum

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