Association Between Serum HMGB-1 (High Mobility Group Box-1) Levels and Clinical Course in Patients With COVID-19
Abstract
Introduction: We aimed to investigate the relationship between serum HMGB-1 levels and the clinical course of COVID-19 disease.
Methods: A total of 86 patients, 43 patients in each group, were included
in the study. According to the Ministry of Health’s COVID-19 Diagnostic
Guide, patients were divided into 2 groups as mild/moderate pneumonia and
severe pneumonia. In addition to routine tests, blood samples were taken
for serum HMGB-1 level analysis. At the time of blood draw, all patients
were within the first 14 days of symptom onset. Results: HMGB-1 (High
mobility group box protein 1) level of the patients in the mild Covid-19
pneumonia group was 4233.84 pg/ml, and the serum HMGB-1 level of
the patients in the moderate-severe pneumonia group was 4804.35 pg/ml.
There was no significant difference between the two groups (P=0.146).
Conclusion: We did not find a significant difference between the two groups in blood samples taken in the first 14
days from the onset of symptoms in COVID-19 patients.
Details
| Primary Language | English |
|---|---|
| Subjects | Traditional, Complementary and Integrative Medicine (Other) |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | July 3, 2023 |
| Published in Issue | Year 2023 |