Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Year 2021, Volume: 3 Issue: 3, 246 - 250, 14.07.2021

Ozgur Oztan , Vugar Ali Türksoy , Serdar Deniz , Engin Tutkun

https://doi.org/10.38053/acmj.959167

Abstract

Objectives: Industrial and agricultural activities such as mining, smelting, and the discharging of industrial and domestic wastewater have increased the severity of heavy metal pollution in environments. Nickel poisoning continues to be an important occupational health problem in many branches of industry especially coating. Occupational exposure to nickel can occur through skin contact or inhalation of nickel-containing aerosols, dusts, or fumes. As a result of the toxic effect of nickel, it can cause various health problems, including respiratory and dermatological effects.
Methods: The study included 56 male workers exposed to nickel in coating factory (Ni-exposed group) and 44 non-exposed male workers (control group). Vascular Cell Adhesion protein (VCAM)-1, Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-10 and IL-6 levels of serum were analyzed using enzyme-linked immunosorbent assays (ELISA). Ni levels were determined using inductively coupled plasma mass spectrometry (ICP-MS) in urine samples.
Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-α, IL-10 and IL-6 (p<0.01 for all).
Conclusions: The correlations between increased inflammatory biomarkers levels and exposed/control groups suggests a close relationship between inflammation and toxicity. This relationship provides a clinical model for the early diagnosis of toxicity of nickel.

Keywords

Nickel exposure, coating workers, inflammation parameters, early diagnosis

References

• Sun Z, Gong C, Ren J, et al. Toxicity of nickel and cobalt in Japanese flounder. Environ Pollut 2020; 263.
• El Safty AMK, Samir AM, Mekkawy MK, Fouad MM. Genotoxic effects due to exposure to chromium and nickel among electroplating workers. Int J Toxicol 2018; 37: 234–40.
• ATSDR. Toxicokinetics and Biomarkers/Environmental Sources of Exposure Normal Human Levels Levels ToxGuide TM General Populations Toxicokinetics Biomarkers 2002; 2. Available from: www.atsdr.cdc.gov
• ATSDR. Toxicology Profile for Nickel. Toxicol Profile Nickel 2005; 1–397.
• Yüksel B, Arica E, Söylemezoglu T. Assessing Reference Levels of Nickel and Chromium in Cord Blood, Maternal Blood and Placenta Specimens from Ankara, Turkey. J Turk Ger Gynecol Assoc 2021; 10.4274/jtgga.galenos.2021.2020.0202.
• World Health Organization. Biological monitoring of chemical exposure in the workplace: Guidelines. Vol. 1. 1996. 300 p.
• Klagsbrun M, D’Amore PA. Vascular endothelial growth factor and its receptors. Vol. 7, Cytokine and Growth Factor Reviews. Elsevier Ltd; 1996. p. 259–70.
• Ozgur O, Vugar Ali T, Iskender Samet D, et al. Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers. Int J Immunother Cancer Res 2019; 5: 001–7.
• Komori A, Yatsunami J, Suganuma M, et al. Tumor Necrosis Factor Acts as a Tumor Promoter in BALB/3T3 Cell Transformation. Cancer Res 1993; 53: 1982–5.
• López P, Gutiérrez C, Suárez A. IL-10 and TNFalpha genotypes in SLE. J Biomed Biotechnol 2010; 2010: 838390.
• Turksoy VA, Tutkun L, Iritas SB, Gunduzoz M, Deniz S. The effects of occupational lead exposure on selected inflammatory biomarkers. Arh Hig Rada Toksikol 2019; 70: 36–41.
• Grimsrud TK, Berge SR, Haldorsen T, Andersen A. Exposure to different forms of nickel and risk of lung cancer. Am J Epidemiol 2002; 156: 1123–32.
• Pavela M, Uitti J, Pukkala E. Cancer incidence among copper smelting and nickel refining workers in Finland. Am J Ind Med 2017; 60: 87–95.
• Wataha JC, O’Dell NL, Singh BB, Ghazi M, Whitford GM, Lockwood PE. Relating nickel-induced tissue inflammation to nickel release in vivo. J Biomed Mater Res 2001; 58: 537–44.
• Wang Z, Yang C. Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis. Semin Cancer Biol 2019; 57: 95-104.
• Capasso L, Camatini M, Gualtieri M. Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells. Toxicol Lett 2014; 226: 28–34.
• Morimoto Y, Ogami A, Todoroki M, et al. Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles. Nanotoxicology 2010; 4: 161–76.
• O’Grady NP, Tropea M, Preas HL, et al. Detection of macrophage inflammatory protein (MIP)-1α and MIP-1β during experimental endotoxemia and human sepsis. J Infect Dis 1999; 179: 136–41.
• Harkin A, Hynes MJ, Masterson E, Kelly JP, O’Donnell JM, Connor TJ. A Toxicokinetic Study of Nickel-Induced Immunosuppression in Rats. Immunopharmacol Immunotoxicol 2003; 25: 655–70.
• Wang PC, Weng CC, Hou YS, et al. Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells. Int J Mol Sci 2014; 15: 3560–79.
• Bogiatzi SI, Fernandez I, Bichet J-C, et al. Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 2007; 178: 3373–7.