The effect of polycystic ovary syndrome on intracytoplasmic sperm injection results in patients with endometriosis

Year 2022, Volume: 4 Issue: 4, 380 - 384, 22.10.2022

Mehmet Ağar , Naziye Gürkan , Tuğba Gürbüz

https://doi.org/10.38053/acmj.1153597

Abstract

Aim: In this study, the fertility rate of women with polycystic ovary syndrome (PCOS) and endometriosis was compared with the control group, which included women with normoresponder (NR) endometriosis.
Material and Method: This is a retrospective study with control in infertile women aged 25-40, suffering from PCOS and endometriosis, referred to the infertility clinic of Medistate Hospital between September 2018- December 2020. The pregnancy outcomes of age-matched participants were compared.
Results: Results did not show a statistically significant association between case and control regarding age and body mass index (BMI) (p>0.05). There was a statistically significant difference between groups regarding anti-mullerian hormone (AMH) (p<0.05). Also, results did not find a statistically significant association between case and NR endometriosis regarding positive pregnancy outcomes (p>0.05).
Conclusion: Women with PCOS and endometriosis did not show a significant difference in terms of pregnancy outcome compared to women with NR women with endometriosis.

Keywords

Polycystic ovary syndrome, intracytoplasmic sperm injection, endometriosis

References

• Alebić MŠ. Endometrial receptivity and PCOS; endometrial gene expression specificities-literature review. Clin. Exp. Obstet. Gynecol 2022; 49: 048
• Gungor ND, Gurbuz T, Demir MK, Yapıcıer Ö, Zer L, Sağıroğlu JŞ. Endometriosis in an episiotomy scar: case report. TJRMS 2018; 2: 30-4.
• Crespi B. Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model. Evol Med Public Health 2021; 9: 295-310. 
• DE Oliveira R, Adami F, Mafra FA, Bianco B, Vilarino FL, Barbosa CP. Causes of endometriosis and prevalent infertility in patients undergoing laparoscopy without achieving pregnancy. Minerva Ginecol 2016; 68: 250-8.
• Dinsdale NL, Crespi BJ. Endometriosis and polycystic ovary syndrome are diametric disorders. Evol Appl 2021; 14: 1693-715. 
• Gaba A, Hörath S, Hager M, Marculescu R, Ott J. Basal anti-mullerian hormone levels and endometrial thickness at midcycle can predict the outcome after clomiphene citrate stimulation in anovulatory women with PCOS, a retrospective study. Arch Gynecol Obstet 2019; 300: 1751-7.
• Gungor ND, Çelik S, Güçlü M, Çelik S, Cengiz F. Evaluation of metabolic and hormonal parameters in women with PCOS living in Black Sea Region. J Exp Clin Med 2021; 38: 235-40.
• Hu M, Zhang Y, Li X, et al. TLR4-associated IRF-7 and NFκB signaling act as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium. J Clin Endocrinol Metab 2021; 106: 1022-40. 
• Jiang NX, Li XL. The Disorders of endometrial receptivity in PCOS and its mechanisms. Reprod Sci 2021: 1-12.
• Becker CM, Bokor A, Heikinheimo O, et al. ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum Reprod Open 2022; 2022: hoac009. 
• Dokuzeylül Güngör N, Güngör K, Yurci A, Cil K, Hatırnaz Ş. Ovarian drilling down-regulates endometrial nuclear factor-κB p65 expression in women with PCOS: a prospective case-control study. Turk J Obstet Gynecol 2022; 19: 45-50.
• Gürbüz T, Dokuzeylül Güngör N, Yurci A. Does intracytoplasmic sperm injection increase the risk of gestational diabetes in patients with polycystic over?. Anatolian Curr Med J 2021; 3: 53-8.
• Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-60.
• Oróstica L, Poblete C, Romero C, Vega M. Pro-inflammatory markers negatively regulate IRS1 in endometrial cells and endometrium from women with obesity and PCOS. Reprod Sci 2020; 27: 290-300.
• Oróstica L, Rosas C, Plaza-Parrochia F, et al. Altered steroid metabolism and insulin signaling in PCOS endometria: impact in tissue function. Curr Pharm Des 2016; 22: 5614-24. 
• Palomba S, Piltonen TT, Giudice LC. Endometrial function in women with polycystic ovary syndrome: a comprehensive review. Hum Reprod Update 2021; 27: 584-618. 
• Piltonen TT. Polycystic ovary syndrome: endometrial markers. Best Pract Res Clin Obstet Gynaecol 2016; 37: 66-79. 
• Rowlands IJ, Teede H, Lucke J, Dobson AJ, Mishra GD. Young women’s psychological distress after a diagnosis of polycystic ovary syndrome or endometriosis. Hum Reprod 2016; 31: 2072-81. 
• Yurci A, Dokuzeylül Güngör N, Güngör K, Hatırnaz Ş. Correlation of serum leptin and ghrelin levels with endocrine and reproductive parameters in women with clomiphene citrate resistant polycystic ovary syndrome. Turk J Obstet Gynecol 2022; 19: 124-9. 
• Shafiee MN, Seedhouse C, Mongan N, et al. Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer. Mol Cell Endocrinol 2016; 424: 94-101.
• Wang T, Zhang J, Hu M, et al. Differential expression patterns of glycolytic enzymes and mitochondria-dependent apoptosis in PCOS patients with endometrial hyperplasia, an early hallmark of endometrial cancer, in vivo and the impact of metformin in vitro. Int J Biol Sci 2019; 15: 714-25. 
• Yuan L, Wu H, Huang W, Bi Y, Qin A, Yang Y. The function of metformin in endometrial receptivity (ER) of patients with polycyclic ovary syndrome (PCOS): a systematic review and meta-analysis. Reprod Biol Endocrinol 2021; 19: 89. 
• Zhai J, Yao GD, Wang JY, et al. Metformin regulates key microRNAs to improve endometrial receptivity through increasing implantation marker gene expression in patients with PCOS undergoing IVF/ICSI. Reprod Sci 2019; 26: 1439-48.