Novel treatment strategies in cancer immunotherapy

Year 2017, Volume: 30 Issue: 2, 36 - 51, 30.06.2018

Cenk Serhan Ozverel , İsmail Karaboz Ayse Nalbantsoy

Abstract

Immune
system has gained importance in research especially in cancer treatment studies
which is also regarded as cancer immunotherapy. Cancers are the leading causes
of death in the world, yet there is no effective therapeutics found against
them. Current treatment strategies are found to be insufficient and
non-specific. Recent studies showed that, for an effective cancer therapy, host
immune system needs to be activated. Research on cancer and tumor
microenvironment provided more molecular information about cancer and immune
cells. Immune based studies on cancer immunotherapy highlighted the importance
of host immune system on cancer eradication. One of the first immunotherapeutic
used against cancer cells are trastuzumab which is a monoclonal antibody targeting
Epidermal Growth Factor Receptor (EGFR). Although, it is regarded as a huge
milestone in cancer immunotherapy, it is found to be insufficient in treatment.
In this review, recent advances in both active and passive immunotherapies are
going to be discussed including the obstacles in the treatment strategies and
studies carried out to overcome them.

Keywords

Immunotherapy, Cancer, Vaccine, mAb

References

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