Kidney Health Consequences of Patients with Glomerulonephritis; Before and After SARS-COV2 Infection

Year 2024, , 324 - 331, 27.10.2024

Buse Dönmez , Özlem Güler , Metin Ergül , Sibel Bek

https://doi.org/10.53446/actamednicomedia.1497244

Abstract

Objective: The virus that causes severe acute respiratory syndrome (SARS-CoV-2) was first identified in Wuhan, China, in December 2019. Recent studies have proven that SARS-CoV-2 is also a nephrotrophic virus.
Methods: Our study aimed to evaluate kidney function and general kidney health of patients with previously diagnosed glomerular diseases and follow-up after SARS-CoV-2 infection. For this purpose, the data of 36 patients who were diagnosed with and routinely followed up for glomerulonephritis and had SARS-CoV-2 infection at the Kocaeli University Faculty of Medicine Hospital nephrology outpatient clinics between January 2020 and January 2022 were examined before and after the infection.
Results: No significant differences were observed in serum creatinine, estimated glomerular filtration rate, and 24-hour urine protein values after infection. There was an increase in platelet and albumin levels following the SARS-CoV-2 infection. A significant decrease was detected in 24-hour urine creatinine values.
Conclusion: The results of the study showed that kidney function and general kidney health of patients with SARS-CoV-2 infection diagnosed with glomerulonephritis were not different when compared to their condition before SARS-CoV-2 infection.

Keywords

COVID-19 infection, glomerulonephritis, chronic kidney disease, vaccine

SARS-COV2 Enfeksiyonundan Önce ve Sonrası Glomerülonefritli Hastaların Böbrek Sağlığı

Abstract

Amaç: Şiddetli akut solunum yolu sendromuna neden olan virüs (SARS-CoV-2) ilk olarak Aralık 2019'da Çin'in Wuhan kentinde tanımlandı. Son çalışmalar SARS-CoV-2'nin de nefrotrofik bir virüs olduğunu kanıtlamıştır.
Yöntem: Çalışmamızın amacı daha önce glomerüler hastalık tanısı konmuş hastaların böbrek fonksiyonlarını ve genel böbrek sağlıklarını değerlendirmek ve SARS-CoV-2 enfeksiyonundan sonra böbrek sağlığı kontrolunü yapmaktır. Bu amaçla Ocak 2020 ile Ocak 2022 arasında Kocaeli Üniversitesi Tıp Fakültesi Hastanesi nefroloji polikliniklerinde glomerülonefrit tanısı konulan ve rutin olarak takibi yapılan, SARS-CoV-2 enfeksiyonu olan 36 hastanın verileri enfeksiyondan öncesi ve sonrası olarak incelendi.
Bulgular: Enfeksiyondan sonra serum kreatinin, tahmini glomerüler filtrasyon hızı ve 24 saatlik idrar protein değerlerinde anlamlı bir fark gözlenmedi. SARS-CoV-2 enfeksiyonundan sonra trombosit ve albümin seviyelerinde artış görüldü. 24 saatlik idrar kreatinin değerlerinde anlamlı bir düşüş tespit edildi.
Sonuç: Çalışmanın sonuçları, glomerülonefrit tanısı konulan SARS-CoV-2 enfeksiyonlu hastaların böbrek fonksiyonlarının ve genel böbrek sağlıklarının, SARS-CoV-2 enfeksiyonundan önceki durumlarıyla karşılaştırıldığında farklı olmadığını gösterdi.

Keywords

COVID-19 enfeksiyonu, glomerülonefrit, kronik böbrek hastalığı, aşı

Ethical Statement

This study complied with the principles of the Declaration of Helsinki. Ethical approval for the study was obtained from the ethics committee of Kocali University Hospital (GOKAEK-2021/170).

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