Fetal büyüme kısıtlılığı ile komplike olan gebeliklerde antenatal kortikosteroid uygulamasının umbilikal arter Doppler velosimetrisi üzerine etkisi

Year 2024, Volume: 7 Issue: 3, 245 - 251, 27.10.2024

Sevda Zamanova , Sunullah Soysal , Merve Demir

https://doi.org/10.53446/actamednicomedia.1374231

Abstract

Amaç: Fetal büyüme kısıtlılığı (FBK) ile komplike olan gebeliklerde antenatal kortikosteroid uygulamasının umbilikal arter (UA) Doppler ölçümleri üzerine etkisini incelemek.

Yöntem: Bu kesitsel çalışma, erken doğum olasılığı nedeniyle antenatal kortikosteroid tedavisi planlanan 149 gebe kadın ile gerçekleştirildi. FBK ile komplike olan ve FBK ile komplike olmayan gebe gruplarında, antenatal kortikosteroid uygulamasından önceki ve son doz kortikosteroid uygulamasından 24 ve 48 saat sonraki UA Doppler ölçümleri (PI, S/D oranı, RI) değerlendirildi ve birbirleriyle karşılaştırıldı.

Bulgular: FBK olan ve olmayan her grupta, antenatal kortikosteroid tedavisinden 24 ve 48 saat sonra UA Doppler parametrelerinde istatistiksel olarak anlamlı bir değişiklik gözlenmedi. FBK olan ve olmayan iki grubun prekortikosteroid UA Doppler parametreleri (PI, S/D oranı, RI) arasında anlamlı fark bulunmazken, son tedavi dozundan 24 saat sonra bu parametrelerin değerleri FBK ile komplike olan grupta komplike olmayan gruba göre istatistiksel olarak yüksekti. Ancak son tedavi dozundan 48 saat sonra iki grup arasında UA Doppler parametrelerinde istatistiksel fark gözlenmedi.

Sonuç: Antenatal kortikosteroid, FBK durumunda UA Doppler parametrelerini kalıcı olarak etkilememektedir. Doğum öncesi kortikosteroidin ilk dozundan sonra 72 saat boyunca fetüsün yakından izlenmesi, FBK ile komplike olan gebe kadınlarda faydalı olabilir.

Keywords

antenatal kortikosteroid, fetal büyüme kısıtlılığı, fetal doppler, umbilikal arter

Ethical Statement

Bu kesitsel çalışma, 02.02.2018 tarihinde, 09.2018.161 protokol koduyla, Marmara Üniversitesi Klinik Araştırmalar Etik Kurulu tarafından onaylandı.

Supporting Institution

Yazarlar bu çalışmanın herhangi bir finansal destek almadığını beyan etmişlerdir.

Thanks

yok

The effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry in pregnancies complicated with fetal growth restriction

Abstract

Objective: To examine the effect of antenatal corticosteroid administration on umbilical artery (UA) Doppler measurements in pregnancies complicated with fetal growth restriction (FGR).

Methods: This cross-sectional study was conducted with 149 pregnant women scheduled for antenatal corticosteroid therapy because of the possibility of preterm birth. UA Doppler measurements (PI, S/D ratio, RI) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated and compared with each other in pregnant groups complicated with FGR and uncomplicated with FGR.

Results: No statistically significant change was observed in UA Doppler parameters 24 and 48 hours after antenatal corticosteroid treatment in each group with and without FGR. While there was no significant difference between the precorticosteroid UA Doppler parameters (PI, S/D ratio, RI) of the two groups with and without FGR, the values of these parameters 24 hours after the last dose of treatment were statistically higher in the group complicated with FGR than in the uncomplicated group. However, no statistical difference was observed in UA Doppler parameters between the two groups 48 hours after the last dose of treatment.

Conclusion: Antenatal corticosteroid does not permanently affect UA Doppler parameters in the case of FGR. Close monitoring of the fetus for 72 hours after the first dose of antenatal corticosteroid may be helpful in pregnant women complicated by FGR.

Keywords

antenatal corticosteroid, fetal growth restriction, fetal doppler, umbilical artery

Ethical Statement

This cross-sectional study was approved by Marmara University Clinical Research Ethics Committee on 02.02.2018 with protocol code 09.2018.161.

Supporting Institution

The authors declared that this study received no financial support

Thanks

unavailable

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