DENTİN BİYOMODİFİKASYONUNDA DOĞAL KAYNAKLI AJANLAR

Year 2021, Volume: 10 Issue: 3, 229 - 237, 20.09.2021

Sultan Bedir , Nurhan Oztas , İlayda Hünler Dönmez , Haluk Bodur

Abstract

Adeziv rezin restorasyonlarda başarısızlığın en sık görüldüğü rezin-dentin ara yüzlerini hidrolitik ve enzimatik bozunmadan korumak, adeziv restorasyonların uzun ömürlülüğü için kritiktir. Adeziv sistemlerin dezavantajlarını azaltabilmeyi hedefleyen dentinin biyomodifikasyonu fikri, biyomekanik ve biyokimyasal özellikleri lokal olarak değiştirerek dentini güçlendirmek için biyoaktif ajanların aracılık ettiği biyomimetik bir yaklaşımdır. Bu derlemenin amacı, hibrit tabaka remineralizasyonu ve rezin-dentin ara yüzünün korunması için umut verici olarak tanımlanan doğal ürünlerin etkinliklerini konuyla ilgili yapılan bilimsel araştırmaların sonuçları doğrultusunda değerlendirmek ve özetlemektir.

Keywords

kolajen çapraz bağlama, dentin, proantosiyonidinler, reçine-dentin arayüzü, yüzey biyomodifikasyonu

NATURAL SOURCE AGENTS IN DENTINE BIOMODIFICATION

Abstract

Protecting the resin-dentine interfaces, where failure is most common in adhesive resin restorations, from hydrolytic and enzymatic degradation is critical for the longevity of adhesive restorations. The idea of biomodification of dentine, which aims to reduce the disadvantages of adhesive systems, is a biomimetic approach mediated by bioactive agents to strengthen dentine by locally changing biomechanical and biochemical properties. The purpose of this review is to evaluate and summarize the efficacy of natural products, which are described as promising for hybrid layer remineralization and preservation of the resin-to-dentine interface, in line with the results of scientific research on the subject.

Keywords

collagen cross-linking, dentine, proanthocyanidins, resin-dentine interfaces, surface biomodification

References

• 1. Cardoso MV, de Almeida Neves A, Mine A, Coutinho E, Van Landuyt K, De Munck J, Van Meerbeek B. Current aspects on bonding effectiveness and stability in adhesive dentistry. Aust Dent J 2011;56(1):31-44.
• 2. Nakabayashi N. The hybrid layer: a resin-dentin composite. Proc Finn Dent Soc Suomen Hammaslaakariseuran toimituksia 1992;88(1):321-329.
• 3. Castellan CS, Pereira PN, Grande, RHM, Bedran-Russo, AK. Mechanical characterization of proanthocyanidin–dentin matrix interaction. Dent Mater 2010;26(10):968-973.
• 4. Braga RR, Fronza, BM. The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review. Dent Mater J 2020;39(1):62-68.
• 5. Cai J, Palamara JEA, Burrow MF. Effects of collagen crosslinkers on dentine: A literature review. Calcif Tissue Int 2018;102(3):265-279.
• 6. Balalaie A, Rezvani MB, Basır MM. Dual function of proanthocyanidins as both MMP inhibitor and crosslinker in dentin biomodification: A literature review. Dent Mater J 2018;37(2):173-182.
• 7. Bedran-Russo AK, Pauli GF, Chen SN, McAlpine JB, Castellan CS, Phansalkar RS, Aguiar TR, Vidal CMP, Napotilano JG, Nam JW, Leme AA. Dentin biomodification: strategies, renewable resources and clinical applications. Dent Mater 2014;30(1):62-76.
• 8. Castellan CS, Bedran-Russo AK, Karol S, Pereira PNR. Long-term stability of dentin matrix following treatment with various natural collagen cross-linkers. J Mech Behav Biomed Mater 2011;4(7):1343-1350.
• 9. Aguiar TR, Vidal CMP, Phansalkar, RS, Todorova I, Napolitano JG, McAlpine JB, Bedran-Russo AK. Dentin biomodification potential depends on polyphenol source. J Dent Res 2014;93(4):417-422.
• 10. Phansalkar RS, Nam JW, Chen SN, McAlpine JB, Napotilano JG, Leme AA, Vidal CMP, Aguiar T, Bedran-Russo AK, Pauli GF. A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential. Fitoterapia 2015;101:169-178.
• 11. Bedran‐Russo AKB, Pashley DH, Agee K, Drummond JL, Miescke KJ. Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res Part B: Applied Biomaterials: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials 2008;86(2):330-334.
• 12. Macedo GV, Yamauchi M, Bedran-Russo AK. Effects of chemical cross-linkers on caries-affected dentin bonding. J Dent Res 2009;88(12):1096-1100.
• 13. Al-Ammar A, Drummond JL, Bedran-Russo AK. The use of collagen cross-linking agents to enhance dentin bond strength. J Biomed Mater Res B, Applied biomaterials 2009;91(1):419-424.
• 14. Liu R, Fang M, Xiao Y, Li F, Yu L, Zhao S, Shen L, Chen J. The effect of transient proanthocyanidins preconditioning on the cross-linking and mechanical properties of demineralized dentin. J Mater Sci Mater Med 2011;22(11):2403-2411.
• 15. Liu Y, Chen M, Yao X, Xu C, Zhang Y, Wang Y. Enhancement in dentin collagen's biological stability after proanthocyanidins treatment in clinically relevant time periods. Dent Mater 2013;29(4):485-492.
• 16. Liu RR, Fang M, Zhang L, Tang CF, Dou Q, Chen JH. Anti-proteolytic capacity and bonding durability of proanthocyanidin-biomodified demineralized dentin matrix. Int J Oral Sci 2014;6(3):168-174.
• 17. Hass V, de Paula AM, Parreiras S, Gutiérrez MF, Luque-Martinez I, de Paris Matos T, Bandeca MC, Loguercio AD, Yao X, Wang Y, Reis A. Degradation of dentin-bonded interfaces treated with collagen cross-linking agents in a cariogenic oral environment: An in situ study. J Dent 2016;49:60-67.
• 18. Yassen AA, Safy RK. Grape Seed Extract And Dentin Remineralization. Egypt Dent J 2018;64(2):1719-1726.
• 19. de Souza LC, Rodrigues NS, Cunha DA, Feitosa VP, Santiago SL, Reis A, Loguercio AD, Perdigao J, de Paulo Aragao Saboia V. Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: a double-blind randomized clinical trial. J Dent 2020;96:103325.
• 20. Tang CF, Fang M, Liu RR, Dou Q, Chai ZG, Xiao YH, Chen JH. The role of grape seed extract in the remineralization of demineralized dentine: Micromorphological and physical analyses. Arch Oral Biol 2013;58(12):1769-1776.
• 21. Silva APPD, Goncalves RS, Borges AFS, Bedran-Russo AK, Shinohara MS. Effectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challenge. J Appl Oral Sci 2015;23(3):302-309.
• 22. Parvathy Premnath JJ, Manchery N, Subbiah GK, Nagappan N, Subramani P. Effectiveness of Theobromine on Enamel Remineralization: A Comparative In-vitro Study. Cureus 2019;11(9): e5686
• 23. Osawa K, Miyazaki K, Shimura S, Okuda J, Matsumoto M, Ooshima T. Identification of cariostatic substances in the cacao bean husk: their anti-glucosyltransferase and antibacterial activities. J Dent Res 2001;80(11):2000-2004.
• 24. Castellan CS, Pereira PN, Viana G, Chen SN, Pauli GF, Bedran-Russo AK. Solubility study of phytochemical cross-linking agents on dentin stiffness. J Dent 2010;38(5):431-436.
• 25. Nam JW, Phansalkar RS, Lankin DC, McAlpine JB, Leme-Kraus AA, Vidal CM, Gan L, Bedran-Russo A, Chen S, Pauli G. Absolute configuration of native oligomeric proanthocyanidins with dentin biomodification potency. J Org Chem 2017;82(3):1316-1329.
• 26. Chengfang T, Jianping R, Yong Z, Zixia L, Yanping Z, Hongyan X. Effect of Pinus massoniana needle extract on root dentin demineralization in vitro. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology 2016;34(5):521-525.
• 27. Zhu Y, Tang C, Ruan J, Luo G, Wang F. Comparative study on the anti-demineralization effect of pinus massoniana bark extract and grape seed extract on human root dentin in vitro. Journal of Practical Stomatology 2017;33(5):589-593.
• 28. Kırzıoğlu Z, Özkul Önol S. Diş Çürüklerini Önlemede Kullanılan Alternatif Materyaller. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2015;24(3):104-112.
• 29. de Macedo FAA, Souza NO, Lemos MVS, De-Paula DM, Santiago SL, Feitosa VP. Dentin bonding and physicochemical properties of adhesives incorporated with epigallocatechin-3-gallate. Odontology 2019;107(1):23-28.
• 30. Hiraishi N, Sono R, Sofiqul I, Yiu C, Nakamura H, Otsuki M, Takatsuka T, Tagami J. In vitro evaluation of plant-derived agents to preserve dentin collagen. Dent Mater 2013;29(10):1048-1054.
• 31. Kato MT, Leite ADL, Hannas AR, Calabria MP, Magalhães AC, Pereira JC, Buzalaf MAR. Impact of protease inhibitors on dentin matrix degradation by collagenase. J Dent Res 2012;91(12):1119-1123.
• 32. Santiago SL, Osorio R, Neri JR, Carvalho RM, Toledano M. Effect of the flavonoid epigallocatechin-3-gallate on resin-dentin bond strength. J Adhes Dent 2013;15(6):535-540.
• 33. Singh P, Nagpal R, Singh UP. Effect of dentin biomodifiers on the immediate and long-term bond strengths of a simplified etch and rinse adhesive to dentin. Restor Dent Endod 2017;42(3):188-199.
• 34. El Baz MA, Aboulenien K. The effect of green tea extract as a matrix metalloproteinase inhibitor on the bond strength of resin composite. Egypt Dent J 2018;64(3),2807-2817.
• 35. De-Paula DM, Lomonaco D, Ponte AMP, Lima MP, Cordeiro KE, Feitosa, VP. Collagen cross-linking of lignin improves etch-and-rinse dentin bonds. [thesis]. Fortaleza: Universidade Federal Do Ceara; 2019.
• 36. Moreira MA, Souza NO, Sousa RS, Freitas DQ, Lemos MV, De Paula DM, Maia FJN, Lomonaco D, Mazzetto SE, Feitosa VP. Efficacy of new natural biomodification agents from Anacardiaceae extracts on dentin collagen cross-linking. Dent Mater 2017;33(10):1103-1109.
• 37. van Strijp AJ, Takatsuka T, Sono R, Iijima Y. Inhibition of dentine collagen degradation by hesperidin: an in situ study. Eur J Oral Sci 2015;123(6):447-452.
• 38. Islam MS, Hiraishi N, Nassar M, Sono R, Otsuki M, Takatsura, Yıu C, Tagami J. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Dent Mater J 2012; 31(3): 362-367.
• 39. Nagpal M, Taneja S, Kumar M, Dudeja C. Evaluation of the effect of natural versus synthetic matrix metalloproteinase silencers in preservation of dentin collagen and long-term bond strength of total etch adhesive. J Conserv Dent 2020;23(3):221.
• 40. Cheng L, Ten Cate JM. (2010). Effect of Galla chinensis on the in vitro remineralization of advanced enamel lesions. Int J Oral Sci 2010;2(1):15-20.
• 41. Zhang T, Chu J, Zhou X. (2015). Anti‐carious Effects of Galla chinensis: A Systematic Review. Phytother Res 2015;29(12):1837-1842.
• 42. Deng M, Dong X, Zhou X, Wang L, Li H, Xu X. Characterization of dentin matrix biomodified by galla chinensis extract. J Endod 2013;39(4):542-547.
• 43. Abdel-Azem HM, Elezz AFA, Safy RK. Effect of Galla Chinensis on Remineralization of Early Dentin Lesion. Eur J Dent 2020;14(4):651-656.