Diş Hekimliğinde Oromaksillofasiyal Bölgeden Alınabilen Mezenkimal Kök Hücreler

Year 2022, Volume: 11 Issue: 2, 184 - 192, 18.05.2022

Sefer Mahmutoğlu , Ayşegül Mendi , Derviş Yılmaz

https://doi.org/10.54617/adoklinikbilimler.996609

Abstract

Oromaksillofasiyal bölge mezenkimal kök hücreler için değerli bir kaynak olup, bu bölgede çekilmiş diş soketleri, çekilmiş dişler, yapışık dişeti dokusu, mandibular ve maksillar kemik iliğinden kolaylıkla mezenkimal kök hücre elde edilebilen kemik, kan damarları diş ve sinirlerden oluşan bir kombine kaynaktır. Kemik iliği kaynaklı mezenkimal kök hücreler, oromaksillofasiyal doku kaynaklı mezenkimal kök hücreler ile benzer özellikte olup alveolar kemik ve sinirlerin rejenerasyonu ,pulpal hasarların önlenmesi ve hasar görmüş dentoalveolar dokuların rejenerasyonu icin biyolojik bir cevap oluşturmaktadır. Ayrıca dişeti kaynaklı mezenkimal kök hücreler immün düzenleyici özellikleri ile klinik uygulamalarda dikkat çekmektedir. Oromaksillofasiyal doku kaynaklı mezenkimal kök hücreler gelecekte maksillofasiyal defektlerin tedavisi açısından büyük ümitler vaad etmektedir. Bu derlemede maksilofasiyal doku kaynaklı mezenkimal kök hücrelerin biyolojik ve fonksiyonel özellikleri ile vaad ettiği gelecek potansiyeli tartışılmıştır.

Keywords

mezenkimal kök hücre, oromaksillofasiyal defektler, diş kaynaklı mezenkimal kök hücreler, alveolar kemik rejenerasyonu, oromaksillofasiyal defekt onarımı

References

• Referans 1. Ghieh F, Jurjus R, Ibrahim A, Geagea AG, Daouk H, El Baba B, et al. The use of stem cells in burn wound healing: a review. Biomed Res Int 2015;1-9.
• Referans 2. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8(4):315–7.
• Referans 3. An Y, Wei W, Jing H, Ming L, Liu S, Jin Y. Bone marrow mesenchymal stem cell aggregate: an optimal cell therapy for full-layercutaneous wound vascularization and regeneration. Sci Rep 2015;5:17036.
• Referans 4. Ducret M, Fabre H, Degoul O, Atzeni G, McGuckin C, Forraz N, et al. Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations. Front Physiol 2015;6(213).
• Referans 5. Kang C-M, Kim H, Song JS, Choi B-J, Kim S-O, Jung H-S, et al. Genetic comparison of stemness of human umbilical cord and dental pulp. Stem Cells Int 2016;2016:1–12.
• Referans 6. Huang YH, Yang JC, Wang CW, Lee SY. Dental Stem Cells and Tooth Banking for Regenerative Medicine. Journal of experimental and clinical medicine 2010; 2(3), 111–7.
• Referans 7. Mendi A, Ulutürk H, Ataç MS, Yilmaz D. Stem cells fort he oromaxillofacial area: could they be a promising source for regeneration in dentistry? Adv Exp Med Biol – Cell Biology and Translational Medicine 2018; 1144:101-21.
• Referans 8. Gronthos S, Mankani M, Brahim J, Gehron Robey P, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci 2000;97 (25):13625–30.
• Referans 9. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829–34.
• Referans 10. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007;131:324–36.
• Referans 11. Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009;88:792–806.
• Referans 12. Niehage C, Karbanová J, Steenblock C, Corbeil D, Hoflack B. Cell surface proteome of dental pulp stem cells identified by label-free mass spectrometry. PLoS One 2016:11(8):e0159824.
• Referans 13. Werle SB, Lindemann D, Steffens D, Demarco FF, de Araujo FB, Pranke P, et al. Carious deciduous teeth are a potential source for dental pulp stem cells. Clin Oral Investig 2016;20(1):75–81.
• Referans 14. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8(4):315–7.
• Referans 15. Mendi A, Gökcinar Yağci B, Kiziloğlu M, Sarac N, Ugur A, Yilmaz D, et al. The effects of Syzygium aromaticum, Cinnamomum zeylanicum, and Salvia triloba extracts on proliferation and differentiation of dental pulp stem cells. J Appl Oral Sci 2017;25(5):515–22.
• Referans 16. Atari M, Caballé-Serrano J, Gil-Recio C, Giner-Delgado C, Martínez-Sarrà E, García-Fernández DA, et al. The enhancement of osteogenesis through the use of dental pulp pluripotent stem cells in 3D. Bone 2012;50(4):930–41.
• Referans 17. Teti G, Salvatore V, Focaroli S, Durante S, Mazzotti A, Dicarlo M, et al. In vitro osteogenic and odontogenic differentiation of human dental pulp stem cells seeded on carboxymethyl cellulose-hydroxyapatite hybrid hydrogel. Front Physiol 2015;6:297.
• Referans 18. Goto N, Fujimoto K, Fujii S, Ida-Yonemochi H, Ohshima H, Kawamoto T, et al. Role of MSX1 in osteogenic differentiation of human dental pulp stem cells. Stem Cells Int 2016;2016,1-13.
• Referans 19. Bhuptani RS, Patravale VB. Porous microscaffolds for 3D culture of dental pulp mesenchymal stem cells. Int J Pharm 2016;515(1–2):555–64.
• Referans 20. Grottkau BE, Purudappa PP, Lin Y. Multilineage differentiation of dental pulp stem cells from green fluorescent protein transgenic mice. Int J Oral Sci 2010;2:21–7.
• Referans 21. Ferro F, Spelat R, Beltrami AP, Cesselli D, Curcio F. Isolation and characterization of human dental pulp derived stem cells by using media containing low human serum percentage as clinical grade substitutes for bovine serum. PLoS One 2012;7(11):e48945.
• Referans 22. Cha Y, Jeon M, Lee H-S, Kim S, Kim S-O, Lee J-H, et al. Effects of in vitro osteogenic induction on in vivo tissue regeneration by dental pulp and periodontal ligament stem cells. J Endod 2015;41:1462–68.
• Referans 23. Ajlan SA, Ashri NY, Aldahmash AM, Alnbaheen MS. Osteogenic differentiation of dental pulp stem cells under the influence of three different materials. BMC Oral Health 2015;2015:15.
• Referans 24. Alraies A, Alaidaroos NYA, Waddington RJ, Moseley R, Sloan AJ. Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities. BMC Cell Biol 2017;18(1):12.
• Referans 25. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284(5411):143–7.
• Referans 26. Mendi A, Gökçinar Yagci B, Sarac N, Kiziloglu M, Ugur A, Uçkan D, et al. Niche differs the effects of Hypericum perforatum L. on the dental pulpand bone marrow-derived mesenchymal stem cells proliferation, osteogenic differentiation, and inflammatory response. Cells Tissues Organs 2018;205:208–16.
• Referans 27. Nemeth CL, Janebodin K, Yuan AE, Dennis JE, Reyes M, Kim D-H. Enhanced chondrogenic differentiation of dental pulp stem cells using nanopatterned PEG-GelMA-HA hydrogels. Tissue Eng Part A 2014;20:2817–29.
• Referans 28. Jang J-H, Lee H-W, Cho KM, Shin H-W, Kang MK, Park SH, et al. In vitro characterization of human dental pulp stem cells isolated by three different methods. Restor Dent Endod 2016;41(4):283–95.
• Referans 29. Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG. Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone 2006;38(6):758–68.
• Referans 30. Carinci F, Piattelli A, Guida L, Perrotti V, Laino G, Oliva A, et al. Effects of Emdogain on osteoblast gene expression. Oral Dis 2006;12(3):329–42.
• Referans 31. Wang Z, Pan J, Wright JT, Bencharit S, Zhang S, Everett ET, et al. Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod 2010;36(5):820–25.
• Referans 32. Moshaverinia A, Chen C, Akiyama K, Ansari S, Xu X, Chee WW, et al. Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study. J Mater Sci Mater Med 2012;23(12):3041–51.
• Referans 33. Moshaverinia A, Chen C, Akiyama K, Xu X, Chee WW, Schricker SR, et al. Encapsulated dentalderived mesenchymal stem cells in an injectable and biodegradable scaffold for applications in bone tissue engineering. J Biomed Mater Res A 2013;101(11):3285–94.
• Referans 34. Moshaverinia A, Chen C, Xu X, Akiyama K, Ansari S, Zadeh HH, et al. Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold. Tissue Eng Part A 2014;20(3–4):611–21.
• Referans 35. Rada C, Jarvis JM, Milstein C. AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc Natl Acad Sci U S A 2002;99(10):7003-8.
• Referans 36. Caton J, Bostanci N, Remboutsika E, De Bari C, Mitsiadis TA. Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. J Cell Mol Med 2011;15(5):1054–65.
• Referans 37. Mitsiadis TA, Woloszyk A, Jimenez-Rojo L. Nanodentistry: combining nanostructured materials and stem cells for dental tissue regeneration. Nanomed 2012;7:1743–53.
• Referans 38. Hayashi Y, Murakami M, Kawamura R, Ishizaka R, Fukuta O, Nakashima M. CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells. Stem Cell Res Ther 2015;6:111.
• Referans 39. Baba S, Yamada Y. Phase I/II trial of autologous bone marrow stem cell transplantation with a threedimensional woven-fabric scaffold for periodontitis. Stem Cells Int 2016;2016:6205910.
• Referans 40. Manimaran K, Sharma R, Sankaranarayanan S, Perumal SM. Regeneration of mandibular ameloblast{ma defect with the help of autologous dental pulp stem cells and bucval pad of fat stromal vascular fraction. Ann MAxillofac Surg 2016;6:97–100.
• Referans 41. D’Aquino R, De Rosa A, Laino G, Caruso F, Guida L, Rullo R, et al. Human dental pulp stem cells: from biology to clinical applications. J Exp Zool B Mol Dev Evol 2009;312(5):408–15.
• Referans 42. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14:529–35.
• Referans 43. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;91:4–15.
• Referans 44. Yamada Y, Ito K, Nakamura S, Ueda M, Nagasaka T. Promising cell based therapy for bone regeneration using stem cekks from deciduous teeth, dental pulp, and bone marrow. Cell Transplant 2011;20:100313.
• Referans 45. Matsuura Y, Atsuta I, Ayukawa Y, Yamaza T, Kondo R, Takahashi A, et al. Therapeutic interactions between mesenchymal stem cell for healing medication related osteonecrosis of the jaw. Stem Cell Res Ther 2016;7;119.
• Referans 46. Cella L, Oppici A, Arbasi M, Moretto M, Piepoli M, Vallisa D, et al. Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw. Head Face Med 2011;7:16.
• Referans 47. Voss PJ, Matsumoto A, Alvarado E, Schmelzeisen R, Duttenhöfer F, Poxleitner P. Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells. Odontology, 2017;105:484-93.
• Referans 48. Nakajima K, Kunimatsu R, Ando K, Ando T, Hayashi Y, Kihara T, et al. Comparison of the bone regeneration ability between stem cells from h{man exfoliated deciduous teeth, human dental pulp stem cells and human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 2018;11(497):876–82.
• Referans 49. Xu J, Su Y, Hu L, Caşn A, Gu Y, Liu B, et al. Effect of bone morphogenetic protein 6 on immnunomodulatory functions of salivary gland derived mesenchymal stem cells in Sjogren’s syndrome. Stem Cells Dev 2018;15(27):1540–8.
• Referans 50. Arora V, Arora P, Munshi AK. Banking stem cells from human exfoliated deciduous teeth (SHED): saving for the future. J Clin Pediatr Dent 2009;33:289–94.
• Referans 51. Mazur P. Freezing of living cells: mechanisms and implications. Am J Phys 1984;247:125–42.