Obez olan ve olmayan periodontitis hastalarında tükürük visfatin, leptin ve oksidatif stres belirteçlerinin değerlendirilmesi.

Year 2022, Volume: 11 Issue: 3, 270 - 279, 19.09.2022

Seval Ceylan Şen , Erkan Özcan , Nuriye Saygun , Taner Özgürtaş , Rashad Azızov

https://doi.org/10.54617/adoklinikbilimler.1106085

Cited By: 1

Abstract

Amaç: Bu çalışmanın amacı obez olan ve olmayan periodontitis hastalarında tükürükte leptin, visfatin, nitrik oksit (NO),total oksidan kapasite (TOK) ve total antioksidan kapasite (TAOK) düzeylerini değerlendirmektir.
Gereç ve Yöntem: Çalışmaya 20 obez periodontal sağlıklı (Grup I), 18 obez periodontitis (Grup II), 20 obez olmayan periodontal sağlıklı (Grup III) ve 20 obez olmayan periodontitis (Grup IV) olmak üzere toplam 78 birey dahil edildi. Periodontal klinik parametreler, vücut kitle indeksi (VKİ) ve bel çevresi ölçümleri kaydedildi. Tükürüğün biyokimyasal analizi için ELISA ve Griess yöntemleri kullanıldı.
Bulgular: Leptin ve TAOC düzeylerinin periodontal sağlıklı gruplarda (Grup I ve Grup III) periodontitis gruplarına (Grup II ve Grup IV) göre daha yüksek olduğu; visfatin, NO ve TOC düzeylerinin de periodontitis gruplarında periodontal olarak sağlıklı gruplara göre daha yüksek olduğu saptandı (P<0.01). NO düzeyi Grup I'de Grup III'e göre daha yüksekti (P<0.01). Grup II'deki visfatin ve NO düzeyleri grup IV'e göre anlamlı derecede yüksekti (sırasıyla P<0.01, P<0.05). Tüm gruplarda (yaş, sondalama derinliği ve VKİ'ye göre) leptin; NO ve TOK ile negatif korelasyon gösterdi ve bu durum, NO ve TOK'un sırasıyla %79 ve %74 varyansını açıklamaktaydı.
Sonuç: Leptin seviyelerindeki değişiklikler oksidatif stresi ve periodontal yıkıma yatkınlığı etkileyebilir. Ayrıca obez hastalarda visfatin ve NO değişiklikleri periodontal yıkımın şiddetini etkileyebilir

Keywords

leptin, obezite, oksidatif stres, periodontitis, visfatin

Thanks

Sayın Editör; ‘Evaluation of salivary visfatin, leptin and oxidative stress markers in obese and non-obese periodontitis patients’ başlıklı araştırma makalemizi Ankara Diş Hekimleri Odası Klinik Bilimler Dergisi’ne değerlendirilmesi amacıyla göndermekten dolayı memnuniyet duyuyoruz. Değerli vaktiniz için teşekkür ederiz. Saygılarımızla, Uzm. Dt. Seval CEYLAN ŞEN

Evaluation of salivary visfatin, leptin and oxidative stress markers in obese and non-obese periodontitis patients.

Abstract

Objectives: The aim of this study is to evaluate leptin, visfatin, nitric oxide(NO), total oxidant capacity(TOC) and antioxidant capacity(TAOC) levels in saliva at obese and non-obese periodontitis patients.
Materials and Methods: Total of 78 individuals were included in study, 20 obese periodontal healthy(Group I), 18 obese periodontitis(Group II), 20 non-obese periodontal healthy(Group III) and 20 non-obese periodontitis(Group IV). Periodontal clinical parameters, body mass index(BMI) and waist circumference measurements were recorded.ELISA and Griess methods were used for biochemical analysis of saliva.
Results: It was determined that leptin and TAOC levels were higher in periodontal healthy groups than in the periodontitis groups; visfatin, NO and TOC levels were higher in periodontitis groups than periodontally healthy groups(P<0.01).The NO level was higher in Group I than in Group III(P<0.01). Visfatin and NO levels in group II were significantly higher than in group IV(P<0.01,P<0.05,respectively). In whole group(adjusted for age, probing depth and BMI)leptin showed negative correlation with NO and TOC, and this explained %79 and %74 variance of NO and TOC respectively.
Conclusions: The changes in leptin levels may affect the oxidative stress and the susceptibility to periodontal destruction.Also, the changes of visfatin and NO may affect the severity of periodontal destruction in obese patients.

Keywords

leptin, obesity, oxidative stress, periodontitis, visfatin

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