Molar Kesici Hipomineralizasyonu’ndan Etkilenmiş Dişlerde Remineralizasyon ve Hassasiyet Giderici Ajanların Değerlendirilmesi
Year 2024,
Volume: 13 Issue: 1, 191 - 201, 26.01.2024
Erenay Alpayçetin
,
Elif Tuna
Abstract
ÖZET
Molar Kesici Hipomineralizasyonu bir veya birden fazla birinci büyük azı ve kesici dişlerde, sınırları belirgin hipomineralize defektlerle karakterize gelişimsel bir mine defektidir. MIH’lı dişlerin mine yapısındaki kalsiyum ve fosfor konsantrasyonu sağlıklı mine ile kıyaslandığında daha düşüktür. Bu dişlerde remineralizasyonu sağlamak amacıyla günümüzde birçok koruyucu yöntem ve ajan ön plana çıkmaktadır. Aynı zamanda artmış porözite ve azalmış mine kalınlığı sebebiyle MIH’tan etkilenmiş dişlerde şiddetli derecede hassasiyet gözlenmektedir. Hassasiyetin ve ağrının yönetiminde koruyucu uygulamalardan, çekime kadar geniş tedavi seçenekleri söz konusudur. Bu derlemede MIH’tan etkilenmiş dişlerde yaşanan aşırı hassasiyetin üstesinden gelinmesi ve remineralizasyonu artırma stratejileri için literatürde yer alan önerilerin tanıtılması amaçlanmıştır.
References
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Sci 2016;6:28-34
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Ashour AA, Al Shamrani AS, et al. Frequency of molar incisor
hypomineralization and associated factors among children with
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FSL. Best clinical practice guidance for clinicians dealing with
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an updated European Academy of Paediatric Dentistry policy
document. Eur Arch Paediatr Dent 2022;23:3-21.
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hypomineralized permanent molars. Pediatr Dent 2007;29:514-
20.
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adolescents with dental enamel defects: etiology, research and
contemporary management. Springer; 2015; p:73-84.
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analysis of hypomineralized enamel in permanent first molars. Int
J Paediatr Dent 2005;15:233–40.
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present-day perspectives of their pathogenesis. Adv Dent Res
1989;3:87–94.
- Referans8. Mahoney EK, Ismail FS, Kilpatrick N, Swain M. Mechanical
properties across hypomineralized/hypoplastic enamel of first
permanent molar teeth. Eur J Oral Sci 2004;112:497–502.
- Referans9. Xie Z, Kilpatrick NM, Swain MV, Munroe PR, Hoffman M.
Transmission electron microscope characterisation of molar-incisorhypomineralisation.
J Mater Sci Mater Med 2008;19:3187–92.
- Referans10. Fearne J, Anderson P, Davis GR. 3D X-ray microscopic study
of the extent of variations in enamel density in first permanent
molars with idiopathic enamel hypomineralisation. Br Dent J
2004;196:634–8.
- Referans11. Farah RA, Drummond BK, Swain M, Williams S. Linking the
clinical presentation of molar-incisor hypomineralisation to its
mineral density. Int J Paediatr Dent 2010;5:353–60.
- Referans12. Jalevik B, Noren JG. Enamel hypomineralization of permanent
first molars: a morphological study and survey of possible
aetiological factors. Int J Paediatr Dent 2000;10:278–89.
- Referans13. Crombie FA, Cochrane NJ, Manton DJ, Palamara JE,
Reynolds EC. Mineralisation of developmentally hypomineralised
human enamel in vitro. Caries Res 2013;47:259–63.
- Referans14. Jalevik B, Klingberg GA. Dental treatment, dental fear and
behaviour management problems in children with severe enamel
hypomineralization of their permanent first molars. Int J Paediatr
Dent 2002;12:24–32.
- Referans15. Kilpatrick NM. New developments in understanding
development defects of enamel: optimizing clinical outcomes. J
Orthod 2009;36:277–82.
- Referans16. Rochel ID, Souza JG, Silva TC, Preira AF, Rios D, Buzalaf
MA, et al. Effect of experimental xylitol and fluoride-contatining
dentifrices on enamel erosion with or without abrasion in vitro. J
Oral Sci 2011;53:163-8.
- Referans17. Weerheijm KL. Molar Incisor Hypomineralization (MIH):
clinical presentation, aetiology and management. Dent Updat
2004;31:9–12.
- Referans18. McDonald S, Arkutu N, Malik K, Gadhia K, McKaig S.
Managing the paediatric patient with amelogenesis imperfecta. Br
Dent J 2012;212:425–8.
- Referans19. Steffen R, Kramer N, Bekes K. The Würzburg MIH concept: the
MIH treatment need index (MIH TNI): A new index to assess and
plan treatment in patieents with molar incisor hypomineralisation
(MIH). Eur Arch Paediatr Dent 2017;18:355-61.
- Referans20. Wang LJ, Tang R, Bonstein T, Bush P, Nancollas GH. Enamel
demineralization in primary and permanent teeth. J Dent Res
2006;85:359–63.
- Referans21. Salanitri S, Seow WK. Developmental enamel defects in the
primary dentition: aetiology and clinical management. Aust Dent
J 2013;58:133–40.
- Referans22. Wright JT. Amelogenesis imperfecta. Eur J Oral Sci
2011;119:338–41.
- Referans23. Elfrink MEC, ten Cate JM, van Ruijven LJ, Veerkamp JSJ.
Mineral content in teeth with Deciduous Molar Hypomineralisation
(DMH). J Dent 2013;41:974–8.
- Referans24. Featherstone JDB. Remineralization, the natural caries
repair process – the need for new approaches. Adv Dent Res
2009;21:4–7.
- Referans25. Oliver K, Messer LB, Manton DJ, Kan K, Ng F, Olsen C, et
al. Distribution and severity of molar hypomineralisation: trial of a
new severity index. Int J Paediatr Dent 2014;24:131– 51.
- Referans26. Linner T, Khazaei Y, Bücher K, Pfisterer J, Hickel R,
Kühnisch J. Hypersensitivity in teeth affected by molar-incisor
hypomineralization (MIH). Sci Rep 2021;11:17922.
- Referans27. Bekes K, Heinzelmann K, Lettner S, Schaller HG. Efficacy
of desensitizing products containing 8% arginine and calcium
carbonate for hypersensitivity relief in MIH-affected molars: an
8-week clinical study. Clin Oral Investig 2017;21:2311-7.
- Referans28. Bekes K, Amend S, Priller J, Zamek C, Stamm T, Krämer N.
Hypersensitivity relief of MIH-affected molars using two sealing
techniques: a 12-week follow-up. Clin Oral Investig 2022;26:1879-
88.
- Referans29. Ozgül BM, Saat S, Sönmez H, Oz FT. Clinical evaluation of
desensitizing treatment for incisor teeth affected by molar-incisor
hypomineralization. J Clin Pediatr Dent 2013;38:101-5.
- Referans30. Muniz RSC, Carvalho CN, Aranha ACC, Dias FMCS, Ferreira
MC. Efficacy of low-level laser therapy associated with fluoride
therapy for the desensitisation of molar-incisor hypomineralisation:
Randomised clinical trial. Int J Paediatr Dent 2020;30:323-33.
- Referans31. Ehlers V, Reuter AK, Kehl EB, Enax J, Meyer F, Schlecht
J, et al. Efficacy of a Toothpaste Based on Microcrystalline
Hydroxyapatite on Children with Hypersensitivity Caused by
MIH: A Randomised Controlled Trial. Oral Health Prev Dent
2021;19:647-58.
- Referans32. Vicioni-Marques F, Paula-Silva FWG, Carvalho MR, Queiroz
AM, Freitas O, Duarte MPF, et al. Preemptive analgesia with
ibuprofen increases anesthetic efficacy in children with severe
molar: a triple-blind randomized clinical trial. J Appl Oral Sci
2022;20:e20210538.
- Referans33. Vieira AEM, Danelon M, Camara DMD, Rosselli ER, Stock
SR, Cannon ML, et al. In vitro effect of amorphous calcium
phosphate paste applied for extended periods of time on enamel
remineralization. J Appl Oral Sci 2017;25:596-603.
- Referans34. Bostancı B, Korkut E, Ünlü N. Başlangıç Mine Lezyonlarının
Florür İçermeyen ve İnvaziv Olmayan Tedavi Yöntemleri. Türkiye
Klinikleri J Restor Dent – Special Topics 2017;3: 7-13.
- Referans35. Uysal S., Tulga F. Derleme: Başlangıç Mine Lezyonlarının
Remineralizasyonunda Kullanılan Ajanlar. AÜ Diş Hek Fak Derg
2018;45:201-10.
- Referans36. Biondi AM, Cortese SG, Babino L, Fridman DE. Comparison
of Mineral Density in Molar Incisor Hypomineralization applying
fluoride varnishes and casein phosphopeptide-amorphous
calcium phosphate. Comparación de Densidad Mineral en
Hipomineralización Molar Incisiva aplicando barnices fluorados y
fosfopéptidos de caseína-fosfato de calcio amorfo. Acta Odontol
Latinoam 2017;30:118-23.
- Referans37. Sezer B, Kargul B. Effect of Remineralization Agents on Molar-
Incisor Hypomineralization-Affected Incisors: A Randomized
Controlled Clinical Trial. J Clin Pediatr Dent 2022;46:192-98.
- Referans38. Amaechi BT, Farah R, Liu JA, Philips TS, Perozo BI, Kataoka
Y, et al. Remineralization of molar incisor hypomineralization
(MIH) with a hydroxyapatite toothpaste: an in-situ study. BDJ
Open 2022;8:33.
- Referans39. Restrepo M, Jeremias F, Santos-Pinto L, Cordeiro RC, Zuanon
AC. Effect of Fluoride Varnish on Enamel Remineralization in
Anterior Teeth with Molar Incisor Hypomineralization. J Clin
Pediatr Dent 2016;40:207-10.
- Referans40. Singh SK, Goyal A, Gauba K, Rathore M. A Comparative
Evaluation of CPP-ACP Cream and Fluoride Varnish in
Remineralization of MIH-affected Teeth Using Laser Fluorescence.
Pediatr Dent 2021;4:117-21.
- Referans41. Kumar A, Goyal A, Gauba K, Kapur A, Singh SK, Mehta SK.
An evaluation of remineralised MIH using CPP-ACP and fluoride
varnish: An in-situ and in-vitro study. Eur Arch Paediatr Dent
2022;23:79-87.
- Referans42. Olgen IC, Sonmez H, Bezgin T. Effects of different
remineralization agents on MIH defects: a randomized clinical
study. Clin Oral Investig 2022;26:3227-38.
- Referans43. Cardoso-Martins I, Arantes-Oliveira S, Coelho A, Pessanha
S, F Marques P. Evaluation of the Efficacy of CPP-ACP
Remineralizing Mousse in MIH White and Yellow Opacities-In Vitro
Vickers Microhardness Analysis. Dent J (Basel) 2022;10:186.
Evaluation of Remineralization and Desensitizing Agents in Molar Incisor Hypomineralization-Affected Teeth
Year 2024,
Volume: 13 Issue: 1, 191 - 201, 26.01.2024
Erenay Alpayçetin
,
Elif Tuna
Abstract
ABSTRACT
Molar Incisor Hypomineralization (MIH) is a developmental enamel defect characterized by prominent hypomineralized defects in one or more first permanent molars and permanent incisors. The enamel structure of MIH-affected teeth exhibits lower concentrations of calcium and phosphates compared to sound enamel. Various preventive methods and agents have emerged today to facilitate remineralization in these teeth. Moreover, the increased porosity and reduced enamel thickness in MIH-affected teeth result in severe sensitivity. Management options for addressing sensitivity and pain in these cases encompass a broad range of treatments, ranging from preventive methods to tooth extraction. This review aims to present recommendations from the existing literature for mitigating the hypersensitivity experienced in MIH-affected teeth, as well as outlining strategies to enhance remineralization.
References
- Referans1. Güner Ş, Salcıoğlu D. Current View on the Diagnosis and
Treatment of Molar Incisor Hypomineralization. Clin Exp Health
Sci 2016;6:28-34
- Referans2. Mohamed RN, Basha S, Al-Thomali Y, Al Zahrani FS,
Ashour AA, Al Shamrani AS, et al. Frequency of molar incisor
hypomineralization and associated factors among children with
special health care needs. Ann Saudi Med 2021;41:238-45.
- Referans3. Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong
FSL. Best clinical practice guidance for clinicians dealing with
children presenting with molar-incisor-hypomineralisation (MIH):
an updated European Academy of Paediatric Dentistry policy
document. Eur Arch Paediatr Dent 2022;23:3-21.
- Referans4. Rodd HD, Boissonade FM, Day PF. Pulpal status of
hypomineralized permanent molars. Pediatr Dent 2007;29:514-
20.
- Referans5. Mahoney EK, Farah R. Planning and care for children and
adolescents with dental enamel defects: etiology, research and
contemporary management. Springer; 2015; p:73-84.
- Referans6. Jalevik B, Dietz W, Noren JG. Scanning electron micrograph
analysis of hypomineralized enamel in permanent first molars. Int
J Paediatr Dent 2005;15:233–40.
- Referans7. Suckling GW. Developmental defects of enamel–historical and
present-day perspectives of their pathogenesis. Adv Dent Res
1989;3:87–94.
- Referans8. Mahoney EK, Ismail FS, Kilpatrick N, Swain M. Mechanical
properties across hypomineralized/hypoplastic enamel of first
permanent molar teeth. Eur J Oral Sci 2004;112:497–502.
- Referans9. Xie Z, Kilpatrick NM, Swain MV, Munroe PR, Hoffman M.
Transmission electron microscope characterisation of molar-incisorhypomineralisation.
J Mater Sci Mater Med 2008;19:3187–92.
- Referans10. Fearne J, Anderson P, Davis GR. 3D X-ray microscopic study
of the extent of variations in enamel density in first permanent
molars with idiopathic enamel hypomineralisation. Br Dent J
2004;196:634–8.
- Referans11. Farah RA, Drummond BK, Swain M, Williams S. Linking the
clinical presentation of molar-incisor hypomineralisation to its
mineral density. Int J Paediatr Dent 2010;5:353–60.
- Referans12. Jalevik B, Noren JG. Enamel hypomineralization of permanent
first molars: a morphological study and survey of possible
aetiological factors. Int J Paediatr Dent 2000;10:278–89.
- Referans13. Crombie FA, Cochrane NJ, Manton DJ, Palamara JE,
Reynolds EC. Mineralisation of developmentally hypomineralised
human enamel in vitro. Caries Res 2013;47:259–63.
- Referans14. Jalevik B, Klingberg GA. Dental treatment, dental fear and
behaviour management problems in children with severe enamel
hypomineralization of their permanent first molars. Int J Paediatr
Dent 2002;12:24–32.
- Referans15. Kilpatrick NM. New developments in understanding
development defects of enamel: optimizing clinical outcomes. J
Orthod 2009;36:277–82.
- Referans16. Rochel ID, Souza JG, Silva TC, Preira AF, Rios D, Buzalaf
MA, et al. Effect of experimental xylitol and fluoride-contatining
dentifrices on enamel erosion with or without abrasion in vitro. J
Oral Sci 2011;53:163-8.
- Referans17. Weerheijm KL. Molar Incisor Hypomineralization (MIH):
clinical presentation, aetiology and management. Dent Updat
2004;31:9–12.
- Referans18. McDonald S, Arkutu N, Malik K, Gadhia K, McKaig S.
Managing the paediatric patient with amelogenesis imperfecta. Br
Dent J 2012;212:425–8.
- Referans19. Steffen R, Kramer N, Bekes K. The Würzburg MIH concept: the
MIH treatment need index (MIH TNI): A new index to assess and
plan treatment in patieents with molar incisor hypomineralisation
(MIH). Eur Arch Paediatr Dent 2017;18:355-61.
- Referans20. Wang LJ, Tang R, Bonstein T, Bush P, Nancollas GH. Enamel
demineralization in primary and permanent teeth. J Dent Res
2006;85:359–63.
- Referans21. Salanitri S, Seow WK. Developmental enamel defects in the
primary dentition: aetiology and clinical management. Aust Dent
J 2013;58:133–40.
- Referans22. Wright JT. Amelogenesis imperfecta. Eur J Oral Sci
2011;119:338–41.
- Referans23. Elfrink MEC, ten Cate JM, van Ruijven LJ, Veerkamp JSJ.
Mineral content in teeth with Deciduous Molar Hypomineralisation
(DMH). J Dent 2013;41:974–8.
- Referans24. Featherstone JDB. Remineralization, the natural caries
repair process – the need for new approaches. Adv Dent Res
2009;21:4–7.
- Referans25. Oliver K, Messer LB, Manton DJ, Kan K, Ng F, Olsen C, et
al. Distribution and severity of molar hypomineralisation: trial of a
new severity index. Int J Paediatr Dent 2014;24:131– 51.
- Referans26. Linner T, Khazaei Y, Bücher K, Pfisterer J, Hickel R,
Kühnisch J. Hypersensitivity in teeth affected by molar-incisor
hypomineralization (MIH). Sci Rep 2021;11:17922.
- Referans27. Bekes K, Heinzelmann K, Lettner S, Schaller HG. Efficacy
of desensitizing products containing 8% arginine and calcium
carbonate for hypersensitivity relief in MIH-affected molars: an
8-week clinical study. Clin Oral Investig 2017;21:2311-7.
- Referans28. Bekes K, Amend S, Priller J, Zamek C, Stamm T, Krämer N.
Hypersensitivity relief of MIH-affected molars using two sealing
techniques: a 12-week follow-up. Clin Oral Investig 2022;26:1879-
88.
- Referans29. Ozgül BM, Saat S, Sönmez H, Oz FT. Clinical evaluation of
desensitizing treatment for incisor teeth affected by molar-incisor
hypomineralization. J Clin Pediatr Dent 2013;38:101-5.
- Referans30. Muniz RSC, Carvalho CN, Aranha ACC, Dias FMCS, Ferreira
MC. Efficacy of low-level laser therapy associated with fluoride
therapy for the desensitisation of molar-incisor hypomineralisation:
Randomised clinical trial. Int J Paediatr Dent 2020;30:323-33.
- Referans31. Ehlers V, Reuter AK, Kehl EB, Enax J, Meyer F, Schlecht
J, et al. Efficacy of a Toothpaste Based on Microcrystalline
Hydroxyapatite on Children with Hypersensitivity Caused by
MIH: A Randomised Controlled Trial. Oral Health Prev Dent
2021;19:647-58.
- Referans32. Vicioni-Marques F, Paula-Silva FWG, Carvalho MR, Queiroz
AM, Freitas O, Duarte MPF, et al. Preemptive analgesia with
ibuprofen increases anesthetic efficacy in children with severe
molar: a triple-blind randomized clinical trial. J Appl Oral Sci
2022;20:e20210538.
- Referans33. Vieira AEM, Danelon M, Camara DMD, Rosselli ER, Stock
SR, Cannon ML, et al. In vitro effect of amorphous calcium
phosphate paste applied for extended periods of time on enamel
remineralization. J Appl Oral Sci 2017;25:596-603.
- Referans34. Bostancı B, Korkut E, Ünlü N. Başlangıç Mine Lezyonlarının
Florür İçermeyen ve İnvaziv Olmayan Tedavi Yöntemleri. Türkiye
Klinikleri J Restor Dent – Special Topics 2017;3: 7-13.
- Referans35. Uysal S., Tulga F. Derleme: Başlangıç Mine Lezyonlarının
Remineralizasyonunda Kullanılan Ajanlar. AÜ Diş Hek Fak Derg
2018;45:201-10.
- Referans36. Biondi AM, Cortese SG, Babino L, Fridman DE. Comparison
of Mineral Density in Molar Incisor Hypomineralization applying
fluoride varnishes and casein phosphopeptide-amorphous
calcium phosphate. Comparación de Densidad Mineral en
Hipomineralización Molar Incisiva aplicando barnices fluorados y
fosfopéptidos de caseína-fosfato de calcio amorfo. Acta Odontol
Latinoam 2017;30:118-23.
- Referans37. Sezer B, Kargul B. Effect of Remineralization Agents on Molar-
Incisor Hypomineralization-Affected Incisors: A Randomized
Controlled Clinical Trial. J Clin Pediatr Dent 2022;46:192-98.
- Referans38. Amaechi BT, Farah R, Liu JA, Philips TS, Perozo BI, Kataoka
Y, et al. Remineralization of molar incisor hypomineralization
(MIH) with a hydroxyapatite toothpaste: an in-situ study. BDJ
Open 2022;8:33.
- Referans39. Restrepo M, Jeremias F, Santos-Pinto L, Cordeiro RC, Zuanon
AC. Effect of Fluoride Varnish on Enamel Remineralization in
Anterior Teeth with Molar Incisor Hypomineralization. J Clin
Pediatr Dent 2016;40:207-10.
- Referans40. Singh SK, Goyal A, Gauba K, Rathore M. A Comparative
Evaluation of CPP-ACP Cream and Fluoride Varnish in
Remineralization of MIH-affected Teeth Using Laser Fluorescence.
Pediatr Dent 2021;4:117-21.
- Referans41. Kumar A, Goyal A, Gauba K, Kapur A, Singh SK, Mehta SK.
An evaluation of remineralised MIH using CPP-ACP and fluoride
varnish: An in-situ and in-vitro study. Eur Arch Paediatr Dent
2022;23:79-87.
- Referans42. Olgen IC, Sonmez H, Bezgin T. Effects of different
remineralization agents on MIH defects: a randomized clinical
study. Clin Oral Investig 2022;26:3227-38.
- Referans43. Cardoso-Martins I, Arantes-Oliveira S, Coelho A, Pessanha
S, F Marques P. Evaluation of the Efficacy of CPP-ACP
Remineralizing Mousse in MIH White and Yellow Opacities-In Vitro
Vickers Microhardness Analysis. Dent J (Basel) 2022;10:186.