D Vitamini Reseptörü Bsm1 Varyantı, Bruksizm Olan veya Olmayan Temporomandibular Bozuklukla İlişkili Değildir

Year 2024, Volume: 13 Issue: 1, 100 - 106, 26.01.2024

Serkan Yıldız , Serbülent Yiğit , Ayşe Feyda Nursal , Nevin Karakuş , Mehmet Kemal Tümer

https://doi.org/10.54617/adoklinikbilimler.1318039

Abstract

Amaç:Temporomandibular eklemi ve ilgili yapıları etkileyen bir dizi durum olan temporomandibular eklem bozukluğu (TMD), sıklıkla bruksizm ile bağlantılıdır. D vitamini reseptörü (VDR) kalsiyum emilimini, kemiğin yeniden şekillenmesini ve mineralizasyon hızını etkiler. Bu çalışmanın amacı, VDR Bsm1 (rs1544410) varyantının TMD'de bruksizme duyarlılıktaki rolünü değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya toplam 321 kişi [221 TMB hastası (135 bruksizmli ve 86 bruksizmsiz) ve 100 sağlıklı kontrol] dahil edildi. VDR Bsm1 varyantı, PCR-RFLP yöntemi kullanılarak genotiplendi.
Bulgular: Tüm TMD hasta grubu ile kontrol grubu arasında VDR Bsm1 genotipi ve alel dağılımı açısından anlamlı fark bulunmadı (p>0,05). Gruplarda VDR varyantı için HWE'den sapma olmadı.Bruksizmli hastalarda ağrı özellikleri ile VDR Bsml genotip dağılımı arasında ilişki yoktu.
Sonuç: Sonuçlarımız, VDR Bsm1 varyantının TMD'de bruksizm gelişimi için bir risk faktörü olmadığı sonucunu desteklemektedir. VDR Bsml varyantının TMD'de bruksizm riski üzerindeki etkisi, daha büyük popülasyonları ve diğer etnik kökenleri içeren çalışmalarda araştırılmalıdır.

Keywords

Bruksizm, D vitamini reseptörü, Temporomandibular eklem hastalığı, PCR-RFLP, Varyant

Supporting Institution

YOK

Project Number

YOK

The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism

Abstract

Background: Temporomandibular joint disorder (TMD), a set of conditions that affect the temporomandibular joint and related structures, is frequently linked to bruxism. The vitamin D receptor (VDR) affects calcium absorption, bone remodeling, and mineralization rate. The goal of this study was to evaluate the role of the VDR Bsm1 (rs1544410) variant in the susceptibility to bruxism in TMD.
Method: A total of 321 people [221 TMD patients (135 with bruxism and 86 without bruxism) and 100 healthy controls] were included in the study. The VDR Bsm variant was genotyped using the PCR-RFLP method.
Results: We found no significant difference between the all-TMD patient group and the control group regarding the VDR Bsm1 genotype and allele distribution (p>0.05). There was no deviation from HWE for the VDR variant in groups. There was no relationship between pain characteristics and VDR Bsml genotype distribution in patients with bruxism.
Conclusions: Our results support the conclusion that the VDR Bsm1 variant is not a risk factor for the development of bruxism in TMD. The effect of the VDR Bsml variant on the risk of bruxism in TMD should be investigated in studies involving larger populations and other ethnicities.

Keywords

Bruxism, Temporomandibular disorder, PCR-RFLP, Variant, ; Vitamin D receptor

Project Number

YOK

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