Diastereomeric Separation of a Novel Chalcone Derivative by Chiral HPLC

Year 2021, Volume: 11 Issue: 1, 205 - 214, 30.06.2021

Ergin Yalçın

https://doi.org/10.37094/adyujsci.936678

Cited By: 1

Abstract

In this study, a facile and versatile procedure for the synthesis of a chalcone derivate that a functionalized (E,Z)-2-(4-aminobenzylidene)acenaphthylen-1(2H)-one, 4 was synthesized and also characterized by using FT-IR, NMR and MS. A new HPLC method for the separation of its diastereomers was developed by using a chiral column that contains the amylose tris(3,5-dimethylphenylcarbamate) as a chiral selector since it is effective, reproducible and can be used for preparative purposes. High percentage recovery claims that the presented method was not affected by the impurities in the biological media. RSD% values for the repeatability studies suggest that the optimized method was highly precise and reproducible which is very important for these promising advances, chalcone-based science is expected to be applied in drug discovery.

Keywords

Chalcone;, Diastereomeric separation;, Acenaphtenone;, Chiral column;, HPLC

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