Tiroid Nodullerinde Ultrasonografik ve Sitolojik bulgular ile Vitamin D Arasındaki İlişkinin Değerlendirilmesi

Year 2019, Volume: 52 Issue: 3, 206 - 213, 21.12.2019

Eray Atalay , Bilge Kağan Tur , Gülizar Kutas Kurt Gül Gürsoy

Abstract

Amaç: Vitamin D ile bazı kanserler arasında bir ilişki olduğu
bildirilmiş, ancak vitamin D ile tiroid kanserleri arasındaki ilişki tam olarak
değerlendirilmemiştir. Bu çalışmanın amacı, D vitamini düzeyleri ile tiroid
nodüllerinin ultrasonografik, sitolojik ve postoperatif patolojik verileri
arasındaki ilişkiyi değerlendirmektir.

Yöntem: Çalışmamıza tiroid nodül varlığı nedeniyle tiroid ince iğne
aspirasyon biyopsisi (TİİAB) sonrası tiroidektomi operasyonu uygulanan 225
hasta dahil edildi. Çalışmaya dahil edilen hastaların preoperatif
ultrasonografik bulguları, TİİAB ve tiroidektomi operasyonu sonrası elde edilen
sitopatolojik sonuçları ile serum vitamin D düzeyleri kaydedildi. Vitamin D
düzeyleri ile tiroid nodüllerinin ultrasonografik ve sitolojik bulguları
arasındaki ilişki analiz edildi.

Sonuçlar: Vitamin D ile tiroid nodüllerinin ultrasonografik
özellikleri, TİİAB ve cerrahi sonrası histopatolojik sonuçları arasında
istatistiksel anlamlı ilişki saptanmadı.

Tartışma: Sonuçlarımız D vitamini ile tiroid nodüllerinin ultrasonografik
özellikleri, TİİAB ve cerrahi sonuçları arasında ilişki olmadığını
göstermiştir. Bununla birlikte, sonuçlarımızı geriye dönük olarak
incelediğimizde, operasyon sonrası malign saptanan çok az sayıda vakanın
preoperatif TİİAB değerlendirmesinde benign saptandığını gözlemledik. Bu
olgular vitamin D düzeyleri düşük ve nodül boyutu 2.5 cm'nin üzerinde olan
olgulardı. Vitamin D eksikliğinin eşlik ettiği büyük tiroid nodülleri ile
malignite arasındaki ilişkiyi değerlendirmek için daha kapsamlı çalışmalara
ihtiyaç olduğunu düşünüyoruz.

Keywords

Vitamin D, Tiroid Nodulü, Ultrasonografi, Sitoloji

The Relationship Between Vitamin D and Ultrasonographic and Cytological Findings of Thyroid Nodules

Abstract

Objective: There are reported associations between Vitamin D and some
cancers, but the relationship between vitamin D and thyroid cancers has not
been fully evaluated. The aim of this study was to evaluate the relationship
between vitamin D levels and ultrasonographical, cytological and postoperative
pathological data of the thyroid nodules.

Methods: The study included 225 patients who underwent thyroidectomy
after thyroid fine needle aspiration biopsy (FNAB) due to the presence of
thyroid nodules.The preoperative ultrasonographical findings, the
cytopathological results obtained after FNAB and thyroidectomy operation and
serum vitamin D levels were recorded. The relationship between vitamin D levels
and ultrasonographical and cytological findings of thyroid nodules was
analyzed.

Results: There was no statistically significant relationship between
vitamin D and ultrasonographical and histopathological results of thyroid
nodules.

Conclusions: Our results showed that there were no relationship
between Vitamin D and ultrasonographical characteristics, biopsy and surgery
results of thyroid nodules. However, when we retrospectively examined our
results, we observed that very few cases with malignancy were found to be
benign in the preoperative FNAB evaluation. These patients had low vitamin D
levels and a nodule size of more than 2.5 cm. We think that more extensive
studies are needed to assess the association between malignancy and large
thyroid nodules associated with vitamin D deficiencies.

Keywords

Vitamin D, Thyroid Nodules, Ultrasonography, Cytology

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