Maküler Kornea Distrofisinde Korneanın Biyomekanik Özellikleri

Year 2021, Volume: 54 Issue: 2, 287 - 291, 31.08.2021

Selma Uzman , Gülizar Demirok Zuleyha Yalnız-akkaya , Umit Eksioglu , Evin Şingar , Mehmet Yakın , Firdevs Ornek , Ayşe Burcu

https://doi.org/10.20492/aeahtd.910968

Abstract

Amaç: Maküler kornea distrofisinin (MKD) korneanın biyomekanik özellikleri üzerindeki etkisinin değerlendirilmesi ve sağlıklı bireyler ile karşılaştırılması amaçlandı.
Gereç ve Yöntem: Klinik olarak MKD tanısı konulmuş 45 hastanın 45 gözü (MKD grubu) ve 61 sağlıklı bireyin 61 gözü (kontrol grubu) çalışma kapsamına alındı. Tam oftalmolojik muayene sonrasında oküler cevap analizörü (ORA) ile, kornea histerezisi (KH), kornea direnç faktörü (KRF), Goldmann ile uyumlu göz içi basıncı (GİBg) ve kornea düzeltmeli GİB (GİBcc) değerleri ve Pentacam veya ultrason pakimetrisi ile merkezi kornea kalınlığı (MKK) ölçüldü ve kaydedildi.
Bulgular: İki grup, ortalama yaş (37,49 ± 10,05 ve 36,70 ± 10,72 yıl, p=0,703) ve cinsiyet dağılımı açısından (p=0,976) benzerdi. Maküler kornea distrofisi grubu ve kontrol grubunda ortalama KH [9,52 ± 1,37 ve 10,99 ± 1,16 mmHg (p <0.001)]; ortalama KRF [8,92 ± 1,48 ve 10,70 ± 1,30 mmHg (p <0,001)]; ortalama MKK [395,71 ± 41,62ve 531,39 ± 28,69 µm (p <0,001)]; ortalama GİBg [12,14 ± 2,49 ve 14,75 ± 2,66 mmHg (p< 0,001)]; ve ortalama GİBcc [13,78 ± 2,65 ve 14,75 ± 2,56 mmHg (p = 0,021)] açısından anlamlı fark tespit edildi. Ancak MKK’nin etkisi istatiksel olarak kontrol altına alındığında, KH, KRF, GİBg ve GİBcc her iki grupta da benzer olarak bulundu.
Sonuç: Maküler kornea distrofisinde ortalama CH, CRF, IOPcc ve IOPg sağlıklı kontrollere göre daha düşüktür. Ancak maküler kornea distrofisinde görülen korneanın kollajen tabakaları ve hücre dışı matriksindeki histopatolojik değişiklikler korneanın biyomekanik özelliklerinde ORA ile tespit edilebilen değişikliğe neden olmamaktadır.

Keywords

Oküler cevap analizörü, kornea histerezisi, kornea direnç faktörü, maküler kornea distrofisi, merkezi kornea kalınlığı

Supporting Institution

yok

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