MALE BREAST CANCER: A RETROSPECTIVE ANALYSIS OF SINGLE CENTER RESULTS

Year 2023, Volume: 56 Issue: 2, 103 - 108, 30.09.2023

Hakan Baysal , Ayşegül Ergün , Begümhan Baysal , Zeynep Çağla Tarcan , Mehmet Sait Özsoy , Fatih Büyüker , Orhan Alimoğlu

https://doi.org/10.20492/aeahtd.1335516

Abstract

AIM
Male breast cancers (MBC), constituting less than 1% of all breast carcinomas, are relatively rare. The average age of diagnosis is between 60-70 years and can affect males of all ages. In this study our aim was to present the clinicopathological characteristics, treatment, and survival outcomes of patients who were treated and followed up for ten years in out clinic, in accordance with literature.
MATERIAL AND METHOD
Records of MBC patients who were followed and treated at our clinic between January 2014 and January 2023 were examined retrospectively using the hospital database. Clinicopathological characteristics, treatments performed, overall and disease-free survival rates were analyzed.
RESULTS
A total of 19 patients were included in the study (mean age: 75.9±11.5, range: 57-96). Four patients with distant metastasis and other system malignancies at the time of diagnosis were excluded. The mean follow-up period was 43.8 months. The most common location of the tumor was to be the retroareolar region (63.2%). BRCA2 gene mutation analysis was positive in three patients. Eleven patients (57.9%) were at Stage 3. Eleven patients had invasive ductal carcinoma. Twelve patients belong to the luminal B subtype. Among the 13 patients who underwent axillary dissection 9 (69.2%) had lymph node involvement. Patients who developed distant metastasis had higher overall mortality and cancer-specific mortality. The body mass index (BMI) of deceased patients was lower than that of surviving patients during the follow-up period. Age group above 75 years had lower overall survival (log-rank p=0.0064) and cancer-specific survival (log-rank p=0.011).
CONCLUSION
In our study, we found that distant metastasis significantly affected the survival. Although male breast cancers are rare, early diagnosis, as in women, positively influences overall and disease-free survival.

Keywords

male breast cancer, survival, metastases, mastectomy

Supporting Institution

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Project Number

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Thanks

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ERKEK MEME KANSERLERİ: TEK MERKEZLİ SONUÇLARIN RETROSPEKTİF ANALİZİ

Abstract

GİRİŞ
Tüm meme karsinomlarının %1’den azını oluşturan erkek meme kanserleri (EMK) oldukça nadirdir. Ortalama tanı 60-70 yaş arasında olup, her yaştan erkek hastalıktan etkilenebilir. Bu çalışmada on yıl boyunca tedavi ve takip edilen hastaların klinikopatolojik özelliklerini, tedavi ve sağkalım sonuçlarını literatür bilgisi ışığında sunmayı amaçladık.
GEREÇ VE YÖNTEM
Ocak 2014-Ocak 2023 tarihleri arasında kliniğimizce takip ve tedavi edilen EMK‘li hastaların retrospektif kayıtları hastane veri tabanından incelendi. Kliniko-patolojik özellikler, yapılan tedaviler, genel ve hastalıksız sağkalım sonuçları analiz edildi.
BULGULAR
Çalışmaya 19 hasta dahil edildi (yaş ortalaması: 75.9±11.5, range:57-96). Tanı anında uzak metastaz ve diğer sistem malignitesi olan 4 hasta dışlandı. Ortalama takip süresi 43.8 aydır. Tümör en sık retroareolar bölgeydi (%63.2). 3 hastada BRCA 2 gen mutasyon analizi pozitif bulundu. 11 hasta (%57.9) Evre 3’tü. 11 hasta invazif duktal karsinomlu idi. 12 hasta Luminal B alt grubunu oluşturmaktaydı. Aksiller diseksiyon yapılan 13 hastanın 9’ da (%69.2 ) tutulum mevcuttu. Uzak metastaz gelişenlerde tüm nedenlere bağlı ve kansere bağlı mortalite daha yüksekti. Ölen hastaların vücut kitle indexi (BMI), izlem süresi içinde sağ olan hastaların BMI’sinden daha düşüktü. 75 yaş ve üstü olan grubun genel sağkalım (log-rank p=0.0064) ve kansere özgü sağkalım (log-rank p=0.011) süresinin belirgin olarak daha kısa olduğu izlenmiştir.
SONUÇ
Çalışmamızda sağkalım üzerine etkide uzak metastaz anlamlı bulunmuştur. Erkeklerde meme kanserleri nadir görülmekle beraber kadınlarda olduğu gibi erken teşhis genel ve hastalıksız sağkalımı olumlu yönde etkilemektedir.

Keywords

erkek meme kanseri, sağkalım, metastaz, mastektomi

Project Number

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