Kolorektal kanserlerde vitamin D reseptör ekspresyonunun kolorektal kanserlerde evre ile ilişkili ve prognoz üzerine etkisi

Year 2019, , 101 - 108, 25.12.2019

Mehmet Sezgin Pepeler , Berna Savaş Merve Pamukcuoğlu Murat Törüner Hakan Akbulut

https://doi.org/10.17941/agd.601187

Cited By: 1

Abstract

Amaç:  Kolorektal kanser  hücrelerinde vit D reseptör ekspresyonunun
tespiti ve bu reseptör ekspresyon derecesi ile kolorektal kanser  prognoz ve evresinin ilişkisi olup olmadığını
tespit etmektir. 

Yöntem ve Gereç: Çalışmaya 2003-2009
tarihleri arasında Ankara Üniversitesi Tıp Fakültesi (AÜTF)  Genel Cerrahi Bölümünde opere olmuş, AÜTF
Patoloji Bölümünde Kolon ve Rektum kanseri  (KRK) tanısı konulup medikal tedavisi AÜTF
Tıbbi Onkoloji Bölümünce yapılan hastalar dahil edilmiştir.Vit D reseptörlerinin değerlendirilmesi için
seçilen olguların Hematoksilen ve Eozin (H-E) kesitleri yeniden
değerlendirildi.

Bulgular:  Vit D reseptörü pozitif
olan hastalarda istatistiksel olarak anlamlı olmasa da medyan   sağkalım
reseptör negatif olanlara göre daha  iyi
bulunmuştur. Vitamin D reseptör (VDR)  pozitif olanlarda medyan sağkalıma
ulaşılamamıştır.5 yıllık sağkalım %69,4 oranında saptanmıştır. VDR negatif
olanlarda medyan sağkalım 60 ay saptanmıştır. 5 yıllık sağkalım %32 oranında
bulunmuştur. VDR pozitif ve negatif olanlar arasında medyan sağ kalım açısından
istatiksel olarak anlamlı fark saptanmamıştır(p:0,053). Hastalıksız sağkalım
için VDR'e göre anlamlı fark saptanmadı.VDR negatif olanlarda 5 yıllık
hastalıksız sağkalım  %56.8 bulunurken, VDR pozitif olanlarda  %43.3 bulunmuştur (Şekil 2.2). 

Sonuç: VDR ekspresyonunun KRK
prognozu üzerine olan etkisinin tek başına anlamlı olmadığı saptanmıştır. 
Reseptör ekspresyonu dışında reseptör polimorfizminin ve reseptörün etkilediği
yolaklarda rol oynayan mutasyonların da prognozu belirlemede etkili olabileceği
kanısına varılmıştır. 

Keywords

Kolorektal karsinom, vitamin D reseptör pozitifliği, immunohistokimya

References

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