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Artmış serum leptin konsantrasyonu hepatit C virüsü ile enfekte hastalarda steatozla ilişkilidir

Year 2011, Volume: 10 Issue: 3, 97 - 103, 01.12.2011

Engin Altıntaş Gönül Aslan Orhan Sezgin Enver Üçbilek Gürol Emektaş Deniz Gezer

Abstract

Giriş ve Amaç: Hepatit C virüsü enfeksiyonunda steatoza yol açan mekanizma karmaşıktır. Bizim çalışmamızın amacı hepatit C virüsü ile ilgili steatozda adipositokinlerin rolünü araştırmaktır. Gereç & Yöntem: Tedavi edilmemiş genotip 1 kronik hepatit C virüslü 65 hasta adipositokinler, beden kitle indeksi, yaş, ve insulin direncinin karaciğer yağlanması ndaki etkilerini değerlendirmek için çalışmaya alındı. Bulgular: Yağlanma 31 (%47.7) hastada gözlendi. Fibroza göre adiponektin ve leptin gruplandırıldığında, adiponektin ve leptin arasında bir fark gözlemlemedik (p sırasıyla 0.597 ve 0.159). Leptin için anlamlı bir fark (p=0.021) varken, steatozlu hastalarda adiponektin düzeyleri arasında bir fark saptamadık (p=0.674). Sonuç: Hiperleptinemi kronik hepatit C virüslü hastalarda steatozun gelişimiyle ilişkilidir.

Keywords

Adiponektin fibroz hepatit C virüsü insulin direnci leptin steatoz

References

  • Lonardo A, Adinolfi LE, Loria P, et al. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-97.
  • Hourigan LF, Macdonald GA, Purdie D, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 1999;29:1215-9.
  • Adinolfi LE, Gambardella M, Andreana A, et al. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001;33:1358-64.
  • Ohata K, Hamasaki K, Toriyama K, et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003;97:3036-43.
  • Rubbia-Brandt L, Quadri R, Abid K, et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genome 3. J Hepatol 2000;33:106-15.
  • Monto A, Alonzo J, Watson JJ, et al. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002;36:729-36.
  • Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000;11:327-32.
  • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-56.
  • Giannini E, Ceppa P, Botta F, et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2000;9:3211-7.
  • Romero-Gomez M, Castellano-Megias VM, Grande L, et al. Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C. Am J Gastroenterol 2003;98:1135-41.
  • Lopez-Bermejo A, Botas P, Funahashi T, et al. Adiponectin, hepatocellular dysfunction and insulin sensitivity. Clin Endocrinol (Oxf) 2004;60:256-63.
  • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-97.
  • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
  • Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5.
  • Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991;13:372-4.
  • Kleiner DE, Brunt EM, Van Natta M, et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21.
  • Gear EB, Shen W. Gender differences in insulin resistance, body composition, and energy balance. Gend Med 2009;6(Suppl 1):6075.
  • Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets 2004;5:241-50.
  • Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9.
  • Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to Cq1, produced exclusively in adipocytes. J Biol Chem 1995;270:26746-9.
  • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-703.
  • Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-96.
  • Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-·, in vivo. J Clin Endocrinol Metab 1997;82:4196-200.
  • Kern PA, Saghizadeh M, Ong JM, et al. The expression of tumour necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111-9.
  • Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-12.
  • Wiman B, Chmielewska J, Ranby M. Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor. J Biol Chem 1984;259:3644-7.
  • Cook KS, Groves DL, Min HY, Spiegelman BM. A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue. Proc Natl Acad Sci U S A 1985;82:6480-4.
  • Maslowska M, Scantlebury T, Germinario R, Cianflone K. Acute in vitro production of acylation stimulating protein in differentiated human adipocytes. J Lipid Res 1997;38:1-11.
  • Bruun JM, Pedersen SB, Richelsen B. Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. J Clin Endocrinol Metab 2001;86:1267-73.
  • Manne J, Argeson AC, Siracusa LD. Mechanisms for the pleiotropic effects of the agouti gene. Proc Natl Acad Sci U S A 1995;92:4721-4.
  • Samad F, Yamamoto K, Pandey M, Loskutoff DJ. Elevated expression of transforming growth factor-‚ in adipose tissue from obese mice. Mol Med 1997;3:37-48.
  • Jones BH, Standridge MK, Taylor JW, Moustaid N. Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am J Physiol 1997;273:R236-42.
  • Heid HW, Moll R, Schwetlick I, et al. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 1998;294:309-21.
  • Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004;25:4-7.
  • Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-8.
  • Jialal I, Devaraj S, Venugopal SK. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 2004;44:6-11.
  • Festa A, Hanley AJ, Tracy RP, et al. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation 2003;108:1822-30.
  • Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002;105:804-9.
  • Liu ZW, Zhang N, Han QY, et al. Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection. World J Gastroenterol 2005;11:3357-62.
  • Piche T, Vandenbos F, Abakar-Mahamat A, et al. The severity of liver fibrosis is associated with high leptin levels in chronic hepatitis C. J Viral Hepat 2004;11:91-6.
  • Crespo J, Rivero M, Fabrega E, et al. Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepatic fibrosis. Dig Dis Sci 2002;47:1604-10.
  • Giannini E, Ceppa P, Botta F, et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2000;95:3211-7.
  • Muzzi A, Leandro G, Rubbia-Brandt L, et al. Swiss Hepatitis C Cohort Study. Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients. J Hepatol 2005;42:41-6.
  • Gordon A, McLean CA, Pedersen JS, et al. Hepatic steatosis in chronic hepatitis B and C: predictors, distribution and effect on fibrosis. J Hepatol 2005;43:38-44.
  • Petit JM, Minello A, Jooste V, et al. Decreased plasma adiponectin concentrations are closely related to steatosis in hepatitis C virus-infected patients. J Clin Endocrinol Metab 2005;90:2240-3.
  • Wang AY, Hickman IJ, Richards AA, et al. High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection. Am J Gastroenterol 2005;100:2717-23.
  • Romero-Gomez M, Del Mar Viloria M, Andrade RJ, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology 2005;128: 636-41.
  • Powell EE, Jonsson JR, Clouston AD. Steatosis: co-factor in other liver diseases. Hepatology 2005;42:5-13.
  • Sato S, Furuta K, Mishiro T, et al. Serum adiponectin concentration in patients with hepatitis C virus. J Clin Gastroenterol 2005;39: 744-5.
  • Liu CJ, Chen PJ, Jeng YM, et al. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J Hepatol 2005;43:235-42.
  • Jonsson JR, Moschen AR, Hickman IJ, et al. Adiponectin and its receptors in patients with chronic hepatitis C. J Hepatol 2005;43:929-36. 1

Increased serum leptin concentration is related to steatosis in hepatitis C virus-infected patients

Year 2011, Volume: 10 Issue: 3, 97 - 103, 01.12.2011

Engin Altıntaş Gönül Aslan Orhan Sezgin Enver Üçbilek Gürol Emektaş Deniz Gezer

Abstract

Background and Aims: The mechanism that leads to steatosis in hepatitis C virus infection is complex. The aim of our study was to search the role of adipocytokines in hepatitis C virus-related steatosis. Materials and Methods: Sixty-five untreated genotype 1 chronic hepatitis C virus patients were included in the study to evaluate the effects of adipocytokines, body mass index, age, and insulin resistance on hepatic steatosis. Results: Steatosis was observed in 31 patients (47.7%). When adiponectin and leptin were grouped according to fibrosis, we did not determine a difference between adiponectin and leptin (p values 0.597 and 0.159, respectively). We did not determine a difference in adiponectin levels in patients with different degrees of steatosis (p=0.674), while there was a significant difference for leptin (p=0.021). Conclusions: Hyperleptinemia is related to the development of steatosis in patients with chronic hepatitis C virus.

Keywords

Adiponectin fibrosis hepatitis C virus insulin resistance leptin steatosis

References

  • Lonardo A, Adinolfi LE, Loria P, et al. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-97.
  • Hourigan LF, Macdonald GA, Purdie D, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 1999;29:1215-9.
  • Adinolfi LE, Gambardella M, Andreana A, et al. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001;33:1358-64.
  • Ohata K, Hamasaki K, Toriyama K, et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003;97:3036-43.
  • Rubbia-Brandt L, Quadri R, Abid K, et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genome 3. J Hepatol 2000;33:106-15.
  • Monto A, Alonzo J, Watson JJ, et al. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002;36:729-36.
  • Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000;11:327-32.
  • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-56.
  • Giannini E, Ceppa P, Botta F, et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2000;9:3211-7.
  • Romero-Gomez M, Castellano-Megias VM, Grande L, et al. Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C. Am J Gastroenterol 2003;98:1135-41.
  • Lopez-Bermejo A, Botas P, Funahashi T, et al. Adiponectin, hepatocellular dysfunction and insulin sensitivity. Clin Endocrinol (Oxf) 2004;60:256-63.
  • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-97.
  • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
  • Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5.
  • Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991;13:372-4.
  • Kleiner DE, Brunt EM, Van Natta M, et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21.
  • Gear EB, Shen W. Gender differences in insulin resistance, body composition, and energy balance. Gend Med 2009;6(Suppl 1):6075.
  • Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets 2004;5:241-50.
  • Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9.
  • Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to Cq1, produced exclusively in adipocytes. J Biol Chem 1995;270:26746-9.
  • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-703.
  • Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-96.
  • Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-·, in vivo. J Clin Endocrinol Metab 1997;82:4196-200.
  • Kern PA, Saghizadeh M, Ong JM, et al. The expression of tumour necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111-9.
  • Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-12.
  • Wiman B, Chmielewska J, Ranby M. Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor. J Biol Chem 1984;259:3644-7.
  • Cook KS, Groves DL, Min HY, Spiegelman BM. A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue. Proc Natl Acad Sci U S A 1985;82:6480-4.
  • Maslowska M, Scantlebury T, Germinario R, Cianflone K. Acute in vitro production of acylation stimulating protein in differentiated human adipocytes. J Lipid Res 1997;38:1-11.
  • Bruun JM, Pedersen SB, Richelsen B. Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. J Clin Endocrinol Metab 2001;86:1267-73.
  • Manne J, Argeson AC, Siracusa LD. Mechanisms for the pleiotropic effects of the agouti gene. Proc Natl Acad Sci U S A 1995;92:4721-4.
  • Samad F, Yamamoto K, Pandey M, Loskutoff DJ. Elevated expression of transforming growth factor-‚ in adipose tissue from obese mice. Mol Med 1997;3:37-48.
  • Jones BH, Standridge MK, Taylor JW, Moustaid N. Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am J Physiol 1997;273:R236-42.
  • Heid HW, Moll R, Schwetlick I, et al. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 1998;294:309-21.
  • Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004;25:4-7.
  • Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-8.
  • Jialal I, Devaraj S, Venugopal SK. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 2004;44:6-11.
  • Festa A, Hanley AJ, Tracy RP, et al. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation 2003;108:1822-30.
  • Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002;105:804-9.
  • Liu ZW, Zhang N, Han QY, et al. Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection. World J Gastroenterol 2005;11:3357-62.
  • Piche T, Vandenbos F, Abakar-Mahamat A, et al. The severity of liver fibrosis is associated with high leptin levels in chronic hepatitis C. J Viral Hepat 2004;11:91-6.
  • Crespo J, Rivero M, Fabrega E, et al. Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepatic fibrosis. Dig Dis Sci 2002;47:1604-10.
  • Giannini E, Ceppa P, Botta F, et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2000;95:3211-7.
  • Muzzi A, Leandro G, Rubbia-Brandt L, et al. Swiss Hepatitis C Cohort Study. Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients. J Hepatol 2005;42:41-6.
  • Gordon A, McLean CA, Pedersen JS, et al. Hepatic steatosis in chronic hepatitis B and C: predictors, distribution and effect on fibrosis. J Hepatol 2005;43:38-44.
  • Petit JM, Minello A, Jooste V, et al. Decreased plasma adiponectin concentrations are closely related to steatosis in hepatitis C virus-infected patients. J Clin Endocrinol Metab 2005;90:2240-3.
  • Wang AY, Hickman IJ, Richards AA, et al. High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection. Am J Gastroenterol 2005;100:2717-23.
  • Romero-Gomez M, Del Mar Viloria M, Andrade RJ, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology 2005;128: 636-41.
  • Powell EE, Jonsson JR, Clouston AD. Steatosis: co-factor in other liver diseases. Hepatology 2005;42:5-13.
  • Sato S, Furuta K, Mishiro T, et al. Serum adiponectin concentration in patients with hepatitis C virus. J Clin Gastroenterol 2005;39: 744-5.
  • Liu CJ, Chen PJ, Jeng YM, et al. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J Hepatol 2005;43:235-42.
  • Jonsson JR, Moschen AR, Hickman IJ, et al. Adiponectin and its receptors in patients with chronic hepatitis C. J Hepatol 2005;43:929-36. 1
There are 51 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Engin Altıntaş This is me

Gönül Aslan This is me

Orhan Sezgin This is me

Enver Üçbilek This is me

Gürol Emektaş This is me

Deniz Gezer

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 10 Issue: 3

Cite

APA Altıntaş, E., Aslan, G., Sezgin, O., Üçbilek, E., et al. (2011). Artmış serum leptin konsantrasyonu hepatit C virüsü ile enfekte hastalarda steatozla ilişkilidir. Akademik Gastroenteroloji Dergisi, 10(3), 97-103.

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