Ustekinumab or vedolizumab for refractory metastatic Crohn's disease?

Year 2024, Volume: 23 Issue: 1, 28 - 31, 25.04.2024

İdris Kurt , Hüseyin Ahmet Tezel

https://doi.org/10.17941/agd.1465245

Abstract

Metastatic Crohn's disease is a rare skin manifestation of Crohn’s disease. A variety of treatment options are available for this condition. But there is a lack of clarity regarding the treatment of resistant cases. There is ongoing debate as to which agent should be selected (vedolizumab or ustekinumab) in patients that are not responding to anti-tumor necrosis factor agents. This study identifies a unique patient who has developed a disease (metastatic Crohn's disease) under treatment with vedolizumab. Following treatment with ustekinumab, the patient regressed completely. Therefore, we recommend ustekinumab primarily in metastatic Crohn's disease.

Keywords

Metastatic Crohn’s disease, ustekinumab, vedolizumab

Refrakter metastatik Crohn hastalığında ustekinumab veya vedolizumab?

Abstract

Metastatik Crohn hastalığı, Crohn hastalığının nadir görülen deri tutulumudur. Bu tutulum için çeşitli tedavi seçenekleri mevcuttur. Ancak dirençli vakaların tedavisi konusunda netlik yoktur. Anti-tümör nekrozis faktör ajanlara yanıt vermeyen hastalarda hangi ajanın (vedolizumab veya ustekinumab) seçilmesi konusunda tartışmalar devam etmektedir. Bu çalışmada, vedolizumab tedavisi altında iken hastalık (metastatik Crohn hastalığı) gelişen benzersiz bir hasta tarif etmekteyiz. Ustekinumab tedavisi sonrası hastalık tamamen geriledi. Bu nedenle metastatik Crohn hastalığında öncelikle ustekinumab tedavisini önermekteyiz.

Keywords

Metastatik Crohn hastalığı, ustekinumab, vedolizumab

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