Apoptotic Effects of Alpha-Linolenic Acid

Year 2024, , 46 - 49, 29.02.2024

Perçin Pazarcı

https://doi.org/10.61845/agrimedical.1356667

Abstract

In recent years, alpha-linolenic acid (ALA), an important omega-3 fatty acid, has become the focus of research due to its potential effects on apoptosis. This review aims to provide an in-depth look at the relationship between ALA and apoptotic pathways and to shed light on the molecular mechanisms that support this interaction. Our study reviews the effect of ALA on apoptosis, examining its effects in various physiological and pathological contexts. It particularly highlights the promising role of ALA in cancer therapy, neurodegenerative disease management, immune system regulation, and incorporation into personalized nutritional strategies. In this review, we aim to guide future research while outlining the diverse applications of ALA in healthcare, emphasizing the importance of conducting comprehensive studies, including animal models and clinical trials, to confirm in vitro findings and uncover the complex molecular mechanisms behind apoptotic modulation of ALA. In conclusion, this study aims to explain the versatile nature of ALA as a bioactive compound and its potential for health due to its effect on apoptosis. Our review aims to provide a comprehensive overview of the current state of knowledge in this field, encouraging further interdisciplinary research and further exploiting the therapeutic potential of ALA's apoptotic effects.

Keywords

Alpha-Linolenic Acid, Apoptosis, Cancer, Neurodegenerative Diseases, Phytotherapy

Alfa-Linolenik Asitin Apoptotik Etkileri

Abstract

Son yıllarda, önemli bir omega-3 yağ asidi olan alfa-linolenik asit (ALA), apopitoz üzerindeki potansiyel etkileri nedeniyle araştırmaların odak noktası olmaya başlamıştır. Bu derleme, ALA ile apoptotik yollar arasındaki ilişkiye derinlemesine bir bakış sunarak, bu etkileşimi destekleyen moleküler mekanizmalara ışık tutmayı amaçlamaktadır. Çalışmamız, ALA'nın apoptoz üzerindeki etkisini gözden geçirerek bunun çeşitli fizyolojik ve patolojik bağlamlardaki etkilerini incelemektedir. Özellikle ALA'nın kanser terapisinde, nörodejeneratif hastalık yönetiminde, bağışıklık sistemi düzenlemesinde ve kişiselleştirilmiş beslenme stratejilerine dahil edilmesinde umut verici rolünü vurgulamaktadır. Derlememizde, ALA'nın sağlık alanındaki çeşitli uygulamalarının ana hatlarını çizerken, in vitro bulguları doğrulamak ve ALA'nın apoptotik modülasyonunun ardındaki karmaşık moleküler mekanizmaları ortaya çıkarmak için hayvan modelleri ve klinik deneyler de dahil olmak üzere kapsamlı çalışmalar yürütmenin önemini vurgulayarak gelecekteki araştırmalara yol göstermeyi hedefliyoruz. Sonuç olarak, bu çalışma ALA'nın biyoaktif bir bileşik olarak çok yönlü doğasını ve apopitoz üzerindeki etkisi dolayısıyla sağlık üzerindeki potansiyelini anlatmayı amaçlamaktadır. Derlememiz bu alandaki mevcut bilgi durumuna kapsamlı bir genel bakış sunarak, daha fazla disiplinlerarası araştırmaya teşvik etmeyi ve ALA'nın apoptotik etkilerinin terapötik potansiyelinden daha fazla yararlanmayı amaçlamaktadır.

Keywords

Alfa-Linolenik Asit, Apoptoz, Kanser, Nörodejeneratif Hastalıklar, Fitoterapi

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