Use of Platelets and Their Properties in Predicting Activity and Fibrosis in HBV Infection

Year 2024, , 61 - 64, 30.06.2024

Adnan Özkahraman , Ozan Durmaz , Mehmet Ali Bilgili , Okan Baybal , Nüket Bayram Kayar , Yusuf Kayar , Melih Karıncaoğlu

https://doi.org/10.61845/agrimedical.1424518

Abstract

Aim: Although liver biopsy is the gold standard for showing histological activity and fibrosis today, there are some non-invasive methods using biochemical calculations as an alternative since it is an invasive procedure. In our study, we aimed to examine the relationship between platelets and some related parameters and histopathology in patients who underwent liver biopsy due to chronic hepatitis B (HBV).
Material and Method: 70 patients diagnosed with chronic HBV and followed up between 2009 and 2013 were included. Demographic data, liver histopathological results and laboratory parameters of all patients were documented. The relationship between histopathology and platelets and some related laboratory parameters was examined.
Results: A total of 70 patients, 40 (28%) of whom were women, were included in the study. A statistically significant relationship was detected between HAI and AST (p=0.001), ALT (p=0.001), Sedimentation (p=0.026, r=0.5) and AAR, APRI, FIB4 (p<0.05).A statistically significant relationship was found between fibrosis and INR (p=0.02, r=0.2), between PDW/PLT, and between PLT/PDW (p<0.05).Additionally, the relationship between fibrosis and APRI, FIB4 and RPR was statistically found significant. (p<0.05).No correlation was found between HAI and Platelet, RDW, PDW (p>0.05).
Conclusions: Platelet and related parameters RDW and RPR have been shown to be associated with the degree of fibrosis. It is thought that RPR, which is an inexpensive and easily calculable index, can predict significant fibrosis and cirrhosis with relatively high accuracy in chronic hepatitis patients, potentially reducing unnecessary liver biopsies.

Keywords

Hepatitis, Platelet, RPR.

Ethical Statement

All participants gave written consent to participate in the study. Approval was received for this study from İnönü University Ethics Committee.

Supporting Institution

İnönü University Ethics Committee

Platelet ve özelliklerinin HBV enfeksiyonunda aktivite ve fibrozis tahmininde kullanımı

Abstract

Amaç: Günümüzde histolojik aktiviteyi ve fibrozisi göstermede altın standart karaciğer biyopsisi olmasına karşın invaziv bir işlem olması nedeniyle alternatif olarak biyokimyasal hesaplanan bazı noninvaziv yöntemler bulunmaktadır. Biz de çalışmamızda kronik hepatit B (HBV) nedeniyle karaciğer biyopsisi yapılan hastalarda platelet ve ilişkili bazı parametrelerin histopatoloji ile olan ilişkisini incelemeyi amaçladık.

Gereç ve yöntem: Kronik HBV tanısı ile 2009 ile 2013 yılları arasında takipli, 70 hasta dahil edildi. Tüm hastaların demografik verileri, karaciğer histopatolojik sonuçları ile laboratuvar parametreleri dökümante edildi. Histopatoloji ile platelet ve ilişkili olduğu bazı laboratuar parametreleri arasındaki ilişki incelendi.

Bulgular: Çalışmaya 40 (%28) kadın olmak üzere toplamda 70 hasta alındı. HAİ ile AST (p=0.001), ALT (p=0.001), Sedimantasyon (p=0.026, r=0.5) ve AAR, APRI, FIB4 (p<0.05) arasında istatistiksel olarak anlamlı ilişki saptandı (p<0.05). Fibrozis ile İNR arasında (p=0.02, r=0.2), PDW/PLT arasında, PLT/PDW arasında (p<0.05) istatistiksel olarak anlamlı ilişki bulundu. Ayrıca Fibrozis ile APRI, FIB4 ve RPR arasındaki ilişki istatistiksel olarak anlamlı bulundu (p<0.05). HAI ile Platelet, RDW, PDW korelasyonu bulunamadı (p>0.05).

Sonuç: Trombosit ve ilişkili parametreler olan RDW ve RPR’nin fibrozisin derecesi ile ilişkili olduğu gösterildi. Pahalı olmayıp kolay hesaplanabilir bir index olan RPR, potansiyel olarak gereksiz karaciğer biopsilerini azaltarak kronik hepatit hastalarında nispeten yüksek doğruluk oranıyla belirgin fibrosis ve sirozu tahmin etmeyi sağlayabileceği düşünülmüştür.

Keywords

Hepatit, Platelet, RPR.

Ethical Statement

Tüm katılımcılar çalışmaya katılmak için yazılı onam verdi. Bu çalışma için İnönü Üniversitesi Etik Kurulundan onay alındı.

Supporting Institution

İnönü Üniversitesi Etik Kurulu

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