Evaluation of Antidepressant Medication Use and Determination of Risk Factors for Depression Among University Students in Istanbul

Year 2021, Volume: 3 Issue: 1, 3 - 18, 31.01.2021

Ecem Yıldız , Nilay Aksoy , Rashida Umar

Abstract

Depression is one of the most common mental health illnesses that can get worse without proper medical interventions. Estimates of the depression prevalence among university students occupy a fair portion of the general depressed populations. This study aimed to assess the prevalence of depression among university students and identifying their characteristics. The conducted cross-sectional study obtained data from different schools located in Istanbul. The highest participation in the study was from Altınbaş, Istanbul, Yeni Yüzyıl and Istinye Universities.
The other universities are Yeditepe, Maltepe, Biruni, Istanbul Technical, Yıldız Technical, Bezmialem, Istanbul Kültür, Beykent and Marmara Universities. This study was conducted between December 2019 and March 2020 after the ethical committee approval. A total of 286 students were included in the study. 75% were female and the mean age and standard deviation (SD) of the students was 21.79 ± 1.775 years. Based on ‘Beck Depression Inventory’, the depressive state was observed to be no or minimal in 59%, mild in 20%, moderate in 16%, and severe in 5% of the participants. The student-related factors, such as the type of the school, cultural-social-financial issues were among the most factors that affect the incidence of depression in students. The students included in this study had only few information about depression and antidepressants which is not enough to understand the whole concept of depression and antidepressants.

Keywords

depression, anxiety, antidepressant, university students, SPSS, Beck Depression Inventory

References

• Acharya, L., Jin, L., & Collins, W. (2018). College life is stressful today – Emerging stressors and depressive symptoms in college students. Journal of American College Health, 66(7), 655–664. https://doi.org/10.1080/07448481.2018.1451869
• Adewuya, A. O., Ola, B. A., Aloba, O. O., Mapayi, B. M., & Oginni, O. O. (2006). Depression amongst Nigerian university students: Prevalence and sociodemographic correlates. Social Psychiatry and Psychiatric Epidemiology, 41(8), 674–678. https://doi.org/10.1007/s00127-006-0068-9
• Akçagöz, H. (2017). Çalışan Kadınların, Benlik Kavramı ile Depresyon Durumunun İncelenmesi Benlik Kavramı ile İdeal Benlik Kavramı Arasındaki Fark ile Depresyon Durumunun Değişkenler Açısından Belirlenmesi [Analysis of depression status with the difference between self-concept of working women and ideal self-concept and self-concept in terms of determining variables of depression status]. (460741) [Master's thesis, Uskudar University]. Ulusal Tez Merkezi. https://tez.yok.gov.tr
• Alhabees, F. A., Alsaida, K. A., & Alhabees, K. A. M. (2018). Levels of Mental Health among University Students: A Comparative Study Between Public and Private University. Journal of Education and Practice, 9(10), 39-44. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An Inventory for Measuring Depression. Archives of General Psychiatry, 4(6), 561. doi: 10.1001/archpsyc.1961.01710120031004.
• Buchanan, J. (2012). Prevention of Depression in the College Student Population: A Review of the Literature. Archives of Psychiatric Nursing, 26, 21–42. https://doi.org/10.1016/j.apnu.2011.03.003
• Burbach, D. J., & Borduin, C. M. (1986). Parent-child relations and the etiology of depression: A review of methods and findings. Clinical Psychology Review, 6(2), 133–153. https://doi.org/10.1016/0272-7358(86)90009-7
• Cohen, L. J. (1997). Rational drug use in the treatment of depression. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 17(1), 45-61. https://doi.org/10.1002/j.1875-9114.1997.tb03677.x
• Demyttenaere, K. (2001). Compliance and acceptance in antidepressant treatment. International Journal of Psychiatry in Clinical Practice, 5(1), 29–35. https://doi.org/10.1080/13651500152048423
• İskender, H., Dokumacıoğlu, E., Kanbay, Y., Kılıç, N. (2018). Üniversite öğrencilerinde sağlıklı yaşam ve depresyon puan düzeyleri ile ilgili faktörlerin belirlenmesi [Determining the healthy life and depression scores with related factors in university students]. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 9(4), 414-423. https://doi.org/10.31067/0.2018.64
• Gao, L., Xie, Y., Jia, C., & Wang, W. (2020). Prevalence of depression among Chinese university students: A systematic review and meta-analysis. Scientific Reports, 10(1), 15897. https://doi.org/10.1038/s41598-020-72998-1
• Gelenberg, A. J., Freeman, M. P., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Van Rhoads, R. S. (2010). American Psychiatric Association practice guidelines for the treatment of patients with major depressive disorder. American Journal of Psychiatry, 167(Suppl 10), 9-118.
• Hammonds, T., Rickert, K., Goldstein, C., Gathright, E., Gilmore, S., Derflinger, B., Bennett, B., Sterns, A., Drew, B. L., & Hughes, J. W. (2015). Adherence to antidepressant medications: A randomized controlled trial of medication reminding in college students. Journal of American College Health, 63(3), 204–208. https://doi.org/10.1080/07448481.2014.975716
• Hisli, N. (1988). Beck Depresyon Envanterinin gecerliligi uzerine bir calisma [A study on the validity of Beck Depression Inventory]. Psikoloji Dergisi, 6(22), 118-122.
• Hisli, N. (1989). Beck Depresyon Envanterinin üniversite öğrencileri için geçerliği, güvenirliği [A reliability and validity study of Beck Depression Inventory in a university student sample]. Psikoloji dergisi, 7(23), 3-13. https://toad.halileksi.net/olcek/beck-depresyon-envanteri
• Hür, S. D., Andsoy, I. I., Şahin, A. O., Kayhan, M., Eren, S., Zünbül, N., Akgün, H., & İnanmaz, N. (2014). Depressive Symptoms in Karabuk University Health School Students. Journal of Psychiatric Nursing, 5(2), 72–76. https://doi.org/10.5505/phd.2014.30075
• Ibrahim, A. K., Kelly, S. J., Adams, C. E., & Glazebrook, C. (2013). A systematic review of studies of depression prevalence in university students. Journal of Psychiatric Research, 47(3), 391–400. https://doi.org/10.1016/j.jpsychires.2012.11.015
• James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., ... & Briggs, A. M. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1789-1858.
• Kadison, R. (2005). Getting an Edge—Use of Stimulants and Antidepressants in College. New England Journal of Medicine, 353(11), 1089–1091. https://doi.org/10.1056/NEJMp058047
• Keitner, G. I., & Miller, I. W. (1990). Family Functioning and Major Depression: An Overview. American Journal of Psychiatry, 147(9), 1128–1137. https://doi.org/10.1176/ajp.147.9.1128
• Kessler, R. C., & Walters, E. E. (1998). Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depression and Anxiety, 7(1), 3–14. https://doi.org/10.1002/(sici)1520-6394(1998)7:1<3::aid-da2>3.0.co;2-f
• Korczak, D. J. (2013). Use of selective serotonin reuptake inhibitor medications for the treatment of child and adolescent mental illness. Paediatrics & Child Health, 18(9), 487–491. https://doi.org/10.1093/pch/18.9.487
• Korkmaz, S. (2006). Üniversite Öğrencilerinde Depresyonun Yordanması: Sosyo-Demografik Değişkenler, Olumsuz Yaşam Olayları, Algılanan Beklentiler, Algılanan İlişkiler [Prediction of Depression in University Students: Socio-Demographic Variables, Negative Life Events, Perceived Expectations, Perceived Relationships] (188819) [Master's thesis, Mersin University]. Ulusal Tez Merkezi. https://tez.yok.gov.tr
• Lane, R., Baldwin, D., & Preskorn, S. (1995). The SSRIs: Advantages, disadvantages and differences. Journal of Psychopharmacology, 9(2_suppl), 163–178. https://doi.org/10.1177/0269881195009002011
• Lugata, S., Elinisa, M., Doshi, B., Kashuta, R. A., Hango, S., Mallosa, W. J., Kelly, C., & Ngocho, J. S. (2020). Symptoms and predictors of depression among university students in the Kilimanjaro region of Tanzania: A cross-sectional study. Journal of Mental Health, 1–8. https://doi.org/10.1080/09638237.2020.1793129
• Maruf, A. A., Greenslade, A., Arnold, P. D., & Bousman, C. (2019). Antidepressant pharmacogenetics in children and young adults: A systematic review. Journal of Affective Disorders, 254, 98–108. https://doi.org/10.1016/j.jad.2019.05.025
• Mirowsky, J., & Ross, C. E. (1992). Age and Depression. Journal of Health and Social Behavior, 33(3), 187. https://doi.org/10.2307/2137349
• Newhart, S., Mullen, P. R., & Gutierrez, D. (2019). Expanding Perspectives: Systemic Approaches to College Students Experiencing Depression. Journal of Counseling & Development, 97(3), 260–269. https://doi.org/10.1002/jcad.12266
• Newman, D. L., Moffitt, T. E., Caspi, A., Magdol, L., Silva, P. A., & Stanton, W. R. (1996). Psychiatric disorder in a birth cohort of young adults: Prevalence, comorbidity, clinical significance, and new case incidence from ages 11 to 21. Journal of Consulting and Clinical Psychology, 64(3), 552–562.
• Ngin, C., Pal, K., Tuot, S., Chhoun, P., Yi, R., & Yi, S. (2018). Social and behavioural factors associated with depressive symptoms among university students in Cambodia: A cross-sectional study. BMJ Open, 8(9), e019918. https://doi.org/10.1136/bmjopen-2017-019918
• North, T. C., McCULLAGH, P., & Tran, Z. V. (1990). Effect of Exercise on Depression. Exercise and Sport Sciences Reviews, 18(1), 379–416.
• Sarokhani, D., Delpisheh, A., Veisani, Y., Sarokhani, M. T., Manesh, R. E., & Sayehmiri, K. (2013). Prevalence of Depression among University Students: A Systematic Review and Meta-Analysis Study. Depression Research and Treatment, 2013, 373857. https://doi.org/10.1155/2013/373857
• Sartorius, N., Üstün, T. B., Lecrubier, Y., & Wittchen, H.-U. (1996). Depression Comorbid with Anxiety: Results from the WHO Study on Psychological Disorders in Primary Health Care. The British Journal of Psychiatry, 168(S30), 38–43. https://doi.org/10.1192/S0007125000298395
• Scheerder, G., De Coster, I., & Van Audenhove, C. (2008). Pharmacists’ Role in Depression Care: A Survey of Attitudes, Current Practices, and Barriers. Psychiatric Services, 59(10), 1155–1160. https://doi.org/10.1176/ps.2008.59.10.1155
• Sokratous, S., Merkouris, A., Middleton, N., & Karanikola, M. (2014). The prevalence and socio-demographic correlates of depressive symptoms among Cypriot university students: A cross-sectional descriptive co-relational study. BMC Psychiatry, 14(1), 235. https://doi.org/10.1186/s12888-014-0235-6
• Wysowski, D. K., Pitts, M., & Beitz, J. (2001). An analysis of reports of depression and suicide in patients treated with isotretinoin. Journal of the American Academy of Dermatology, 45(4), 515–519. https://doi.org/10.1067/mjd.2001.117730
• Zafar, M., Rizvi, S. B., Sheikh, L., Khalid, Z., Abbas, T. G., Waseem, S., Khan, A., Aijaz, S., Akram, S., Arshad, S., Khalid, U., Shahid, B., Ahmed, S., Aftab, M., Usman, A., & Aslam, R. (2017). Comparative analysis of depression and its associated risk factors among public and private medical schools students in Karachi, Pakistan: A multicenter study. Saudi Journal for Health Sciences, 6(1), 8.