Demir Fazlalığı İçin Şelasyon Tedavisi ve Şelasyon Ligandları

Year 2019, Volume: 28 Issue: 1, 66 - 81, 31.03.2019

Gülüzar Özbolat , Abdullah Tuli

Abstract

Demir fazlalığı büyük ölçüde şelatlama ajanları kullanılarak önlenebilen, vücudun farklı bölgelerinde demirin fazla şekilde depolanma durumudur.  İnsan vücudu demir fazlalığını gidermek için fizyolojik bir mekanizmaya sahip değildir. Demir fazlalığının tedavisi için şu an uygulanan yöntem şelasyon tedavisidir. Demir şelasyon tedavisi, potansiyel olarak demir fazlalığı hastalığının tedavisinde demire bağlanan ligandların kullanımını içerir. Bu derlemede insanda demir fazlalığı oluşma nedenleri ve oluşması durumunda kullanılan şelatörler ve klinikte deneme aşamasında olan şelatörler ile ilgili son gelişmeleri bilgi vererek aktarmaya çalıştık.

Keywords

Demir fazlalığı, şelasyon, ligand, demir

Chelation Therapy and Chelating Ligands for Iron Overload

Abstract

Iron overload is a condition of excess iron stores in different parts of body which can be largely prevented by the use of chelating agents. The human body doesn’t have any a physiological mechanism to eliminate iron overload. Currently applied methods for treatment of iron overload consisting of chelation therapy. Iron chelation therapy involves the use of ligating drugs that avidly bind iron for the treatment of potentially iron overload disease. In this review, we tried to give information about the reasons for the occurrence of iron overload in the human body, the latest developments in chelators and chelators that are in the trial phase at the clinic.

Keywords

Iron overload, chelation, ligand, iron, chelator

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