Fare ve Ratlarda Yapay Tatlandırıcıların Bağırsak Mikrobiyotası Üzerine Etkisi: Randomize Kontrollü Çalışmaların Sistematik Derlemesi

Year 2022, Volume: 31 Issue: 2, 99 - 110, 30.06.2022

Emre Duman , Alev Keser , Selen Yılmaz Işıkhan

https://doi.org/10.17827/aktd.1039222

Abstract

Yapay tatlandırıcıların bağırsak mikrobiyotası üzerine etkisini inceleyen fare ve ratlarda yapılmış randomize kontrollü çalışmaların sistematik olarak incelenmesidir. PRISMA bildirgesi rehber alınarak PubMed, Web of Science, EBSCOHost ve Google Akademik olmak üzere 4 veri tabanı kullanılmış, 1 Ocak 2000-31 Aralık 2020 tarihleri arasında yayınlanan tüm rat ve fareler ile ilgili randomize kontrollü çalışmaları belirlemek için sistematik bir tarama yapılmıştır. Yapay tatlandırıcı olarak advantam, asesülfam-K, aspartam, neotam, sakkarin, siklamat ve sükraloz kullanılan çalışmalar dahil edilmiştir. İlk tarama sonucunda fare ve ratlar üzerinde yapılan toplam 901 çalışma elde edilmiştir. Çalışmanın amacına ve dahil etme kriterlerine uygun 11 randomize kontrollü çalışma sistematik derlemeye dahil edilmiştir. Çalışmalardan iki tanesi ratlar üzerinde, dokuz tanesi ise fareler üzerinde gerçekleştirilmiştir. Dahil edilme kriterlerini karşılayan advantam ve siklamat ile yapılmış çalışmaya literatürde rastlanmamıştır. Örneklem sayısının az olması nedeniyle meta-analiz yapılamamıştır. Fare ve ratlarda yapay tatlandırıcıların bağırsak mikrobiyotası üzerine etkisi olmakla birlikte etkisine yönelik net bir kanıt ortaya konulamamıştır. Bağırsak mikrobiyomundaki değişikliklerin insan sağlığını nasıl etkilediğinin araştırılması önemlidir ve bu nedenle yapay tatlandırıcı tüketiminin mikrobiyota üzerindeki etkisini değerlendiren randomize kontrollü klinik çalışmaların sayısının artması önemli bir gerekliliktir.

Keywords

Mikrobiyota, sistematik derleme, yapay tatlandırıcılar.

Effect of Artificial Sweeteners on Gut Microbiota in Mice and Rats: A Systematic Review of Randomized Controlled Studies

Abstract

It is a systematically examine of randomized controlled studies in mice and rats examining effects of artificial sweeteners on gut microbiota. Based on the PRISMA declaration, 4 databases were used, namely PubMed, Web of Science, EBSCOHost and Google Scholar, and a systematic search was conducted to identify randomized controlled studies on all rats and mice published between January 1, 2000-December 31, 2020. Studies using advantam, acesulfame-K, aspartame, neotame, saccharine, cyclamate, and sucralose as artificial sweeteners are included. As a result of first screening, a total of 901 studies on mice and rats were obtained. Eleven randomized controlled trials that met the study objective and inclusion criteria were included in systematic review. Two of studies were carried out on rats and nine of them were performed on mice. No study with advantam and cyclamate meeting the inclusion criteria was found in literature. Due to small sample size, meta-analysis could not be performed. Although artificial sweeteners have an effect on intestinal microbiota in mice and rats, no clear evidence for its effect has been demonstrated. It is important to investigate how changes in gut microbiome affect human health, and therefore it is essential to increase number of randomized controlled clinical trials evaluating effect of artificial sweetener consumption on the microbiota.

Keywords

Microbiota, systematic review, artificial sweeteners

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