İntrabdominal Adezyon Oluşum Mekanizmalarına ve Tedavi Stratejilerine Histopatolojik Bakış

Year 2022, Volume: 31 Issue: 4, 264 - 272, 30.12.2022

Ebru Eroğlu , Yiğit Uyanıkgil

https://doi.org/10.17827/aktd.1116761

Abstract

Hayat standartlarını olumsuz etkileyen abdominal adezyonlar, postoperatif dönemde görülen önemli bir sağlık sorunudur. Peritoneal kavite ve serozal yüzeylerde oluşan, abdominal travmalara sebep olan kimyasal ve termal faktörler ya da enfeksiyon ve yabancı cisim reaksiyonları adezyon oluşumuna sebep olabilir. Abdominal adezyonların sınıflandırması genellikle adezyon yoğunluğuna ve prognoz ciddiyetine göre yapılsa da henüz dünya çapında kabul görmüş standart bir sınıflandırma sistemi mevcut değildir. Abdominal adezyonlar ağrı, infertilite, cerrahi sonrası hastanede yatış süresinin uzaması ve ekonomik yük gibi olumsuz sonuçlarla klinik yansımalar gösterir. Sonuç olarak, postoperatif süreçte karşılaşılan adezyonlar ciddi bir sorundur ve adezyon oluşumunu engellemek için ileri çalışmaların laboratuvar ortamından klinik araştırma modellerine uyarlanması gerekmektedir. Bu derleme çalışması intraabdominal adezyon oluşumu, histopatolojisi, derecelendirilmesi, önlenmesi ve klinik önemi ile ilgili literatürü gözden geçirmek için hazırlanmıştır.

Keywords

Periton, adezyon, histopatoloji

Supporting Institution

Yoktur

Project Number

Yoktur

Histopathological Overview of Intrabdominal Adhesion Formation Mechanisms and Treatment Strategies

Abstract

Abdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. Chemical and thermal factors that occur in the peritoneal cavity and serosal surfaces, causing abdominal trauma, or infection and foreign body reactions may cause adhesion formation. Although the classification of abdominal adhesions is generally based on adhesion density and severity of prognosis, there is not yet a worldwide accepted standard classification system. Abdominal adhesions show clinical reflections with negative consequences such as pain, infertility, prolonged hospital stay after surgery and economic burden. In conclusion, adhesions encountered in the postoperative period are a serious problem and further studies should be adapted from laboratory environment to clinical research models in order to prevent adhesion formation. This review was prepared to review the literature on intra-abdominal adhesion formation, histopathology, grading, prevention and clinical significance.

Keywords

Peritonium, Adhesion, Histopathology

Project Number

Yoktur

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