Kök Hücreler, Dental Pulpa Kök Hücreleri ve Klinik Uygulamaları

Year 2024, Volume: 33 Issue: 3, 145 - 155, 30.09.2024

Derin Atasever , Özgün Selim Germiyan , Yiğit Uyanıkgil

https://doi.org/10.17827/aktd.1511375

Abstract

Son yıllardaki en önemli araştırma konularından biri olan kök hücreler; kolay bir şekilde ulaşılabilmeleri ve çoğaltılabilmeleri, doku tamiri ve yenilemesinde başarılı olmaları, bağışıklık sistemi üzerinde düzenleyici etkiye sahip (immünomodülatör) olmaları, farklı dokulardan izole edilebilmeleri ve birçok hücre çeşidine farklılaşabilmeleri sebebiyle doku mühendisliği ve rejeneratif tıp çalışmalarının da önemli bir parçası haline gelmiştir. İlaç ve tedavi araştırmalarında, hastalıkların oluşum mekanizmalarının, etkilerinin ve olası sonuçlarının daha detaylı bir şekilde incelenmesinde, hücre kültürü çalışmalarında, laboratuvar ortamında fonksiyonel dokuların geliştirilmesinde, hücre terapilerinde, hasarlı doku ve organ rejenerasyonunda kök hücreler sıklıkla kullanılmakta ve bu alandaki çalışmalar hızla ilerlemektedir.
Yetişkin diş pulpasından enzimatik olarak ayrıştırılan, yüksek proliferatif özellik gösteren hücreler; ilk defa “dental pulpa kök hücresi” olarak tanımlanmış ve bu terim literatüre kazandırılmıştır. Ayrıca ilk defa dental pulpa kök hücreleri başarıyla izole edilmiş ve odontoblast benzeri yapılara farklanarak dentin/pulpa benzeri bir kompleks oluşturabildiği, dentinogeneze katkı sağladığı bildirilmiştir. Bu çalışmadan sonra dental pulpa kök hücreleriyle ilgili tıp ve diş hekimliği alanındaki araştırmalar, büyük bir hız kazanarak günümüze kadar gelmiştir.

Keywords

Dental pulpa kök hücreleri, rejenerasyon yeteneği, diş hekimliğinde kök hücreler

Ethical Statement

Yazarlar, Arşiv Kaynak Tarama Dergisinin Etik İlkeler ve Yayın Politikasına uygun davrandıklarını beyan etmişlerdir.

Stem Cells, Dental Pulp Stem Cells and Their Clinical Applications

Abstract

Stem cells as one of the most important research topics in recent years; They have become an important part of tissue engineering and regenerative medicine studies because they can be easily accessed and reproduced, are successful in tissue repair and renewal, have a regulatory effect on the immune system (immunomodulator), can be isolated from different tissues and can differentiate into many cell types. Stem cells are frequently used in drug and treatment research, in more detailed examination of the formation mechanisms, effects and possible consequences of diseases, in cell culture studies, in the development of functional tissues in the laboratory environment, in cell therapies, and in damaged tissue and organ regeneration.
Cells with high proliferative properties, separated enzymatically from adult dental pulp; It was defined as "dental pulp stem cell" for the first time and this term was introduced into the literature. In addition, dental pulp stem cells have been successfully isolated for the first time and it has been reported that they can differentiate into odontoblast-like structures and form a dentin/pulp-like complex, contributing to dentinogenesis. After this study, research on dental pulp stem cells in the field of medicine and dentistry has gained great momentum and has continued to this day.

Keywords

Dental pulp stem cells, Regeneration skills of stem cells, Use of stem cells in dentistry

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