Potansiyel Kıkırdak Tedavisi için Poliakrilamid/Aljinat Hibrit Hidrojellerin Mekanik ve Tribolojik Analizi

Year 2022, Volume: 22 Issue: 1, 252 - 261, 28.02.2022

Yusuf Kanca , Emir Avcıoğlu , Lynne Hopkins Ercan Bilge

https://doi.org/10.35414/akufemubid.1015110

Cited By: 1

Abstract

Bu çalışmada sentezlenen poliakrilamid/aljinat (PAAm/Alg) bazlı hidrojellerin mekanik ve tribolojik özellikleri incelenmiştir. Üretilen dört farklı hidrojel farklı konsantrasyonlarda tek veya çift ağ yapılı polimerlerden oluşmaktadır: ağırlıkça %15 tek ağ yapılı (SN-15), %30 tek ağ yapılı (SN-30), %15 çift ağ yapılı (DN-15) ve %30 çift ağ yapılı (DN-30). Sentezlenmiş hidrojellerin tribolojik performansı, özel olarak tasarlanmış pin-on-disk tribometre ile, 37±1 °C sıcaklıkta fosfat tamponlu salin (PBS) içerisinde, ortalama kayma hızı 20 mms-1 olan CoCrMo femur kafasının altında 5 veya 10 N’luk yükler uygulanıp lineer git-gel hareketi ile incelenmiştir. Hidrojellerin sıkıştırma tanjant modülü, PBS’ye daldırılmış numunelerin hem ortam hem de vücut sıcaklarında 1 dak-1 gerinim hızında sıkıştırılmasıyla belirlenmiştir. Test sonuçları daha yüksek polimer konsantrasyonu veya çift ağ tipi bir yapıya sahip olmanın hidrojellerin gelişmiş sürtünme (düşük sürtünme katsayısı) ve aşınma (düşük aşınma izi alanı) özelliklerine sahip olmasına yol açtığını göstermiştir. Hidrojellerin daha düşük yük altında daha iyi performans gösterdiği gözlemlenmiştir. DN-30 olarak kodlanan numune en yüksek sıkıştırma modülü davranışını sergilemiştir. Bu sonuçlar, fizyolojik koşullar altında PAAm/Alg karışımı hidrojellerin mekanik ve tribolojik performansının anlaşılmasına katkıda bulunmuştur.

Keywords

Poliakrilamid, Aljinat, Kıkırdak tedavisi, Triboloji, Basma davranışı

Mechanical and Tribological Analysis of Polyacrylamide/Alginate Hybrid Hydrogels for Potential Cartilage Treatment

Abstract

In this study, polyacrylamide/alginate (PAAm/Alg) based hydrogels have been synthesized and investigated. The four different hydrogels produced contained different concentrations of single- or double- network polymer: 15 wt.% single-network (SN-15), 30 wt.% single-network (SN-30), 15 wt.% double-network (DN-15), and 30 wt.% double-network (DN-30). The tribological performance of these synthesized hydrogels was investigated by using a custom pin-on-disc tribometer in phosphate buffered saline (PBS), where samples were reciprocated against a CoCrMo femoral head under an applied load of 5 or 10 N, at an average sliding speed of 20 mms-1, and body temperature (37±1 °C). The compressive tangent modulus was also determined by compressing samples at a strain rate of 1 min-1, while submerged in PBS, at both ambient and body temperatures. The results showed that a higher polymer concentration or a double-network type of structure led to improved friction (lower friction co-efficient) and wear (lower wear track area) properties. Samples also performed better when a lower applied load used. Sample DN-30 exhibited the highest compressive modulus. These outcomes have contributed to the understanding of the mechanical and tribological performance of PAAm/Alg blend hydrogels when performing under certain physiological conditions.

Keywords

Polyacrylamide, Alginate, Cartilage treatment, Tribology, Compressive behaviour

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