Portable magnetic nanoparticle spectrometer

Year 2019, Volume: 2 Issue: 1, 1 - 9, 16.06.2019

Yeşim Akyürekli , Cengiz Akay , Elif Uzak Adem Tunçdamar

Abstract

The magnetic particle spectrometer (MPS)
uses the nonlinear response of super-paramagnetic iron oxide nanoparticles and
magnetic saturation at certain magnetic field values. A time-varying magnetic field
of excitation coils causes the magnetization of the particles to vary between
the maximum and the minimum value. Generally, there are two ways in which a
magnetic nanoparticle can change the direction when the applied area is
temporarily changed. The particle itself performs a physical rotation called
the Brown return, or the magnetic moment in the particle can rotate in a fixed
structure called the Néel return. In a viscous environment, the combination of
both types of rotation takes place, which depends on the frequency applied and
is a dominant process. This process, also known as the relaxation meter, takes
into account the density of the magnetic nanoparticles in the MPS studies and
the measurement of the relaxation times of the nanoparticles by making the
corresponding calculations. Brown or Néel breakdown times can be calculated
according to the reaction of chemically bound or unbound magnetic nanoparticles
to the external variable magnetic field. In this study, a spectrometer was
first designed and constructed to analyze the properties of nanoparticles such
as relaxation times. MPS signals obtained from the spectrometer can be
transferred to the computer with data acquisition card and data analysis can be
done with a software written in python programming language.

Keywords

magnetic particle spectrometer, magnetic nanoparticles parameters, nonlinear magnetization, FFT

References

• Articles1. Yan Tan, Yang Yu, Xing Lv, Ming Wang. Design and Simulation of Magnetic Nanoparticles Detector Based on the Nonlinear Magnetization, 2013 6th International Conference on Biomedical Engineering and Informatics (BMEI 2013).
• 2. André Behrends, Matthias Graeser and Thorsten M. Buzug. Introducing a frequency-tunable magnetic particle spectrometer, De Gruyyer, Current Directions in Biomedical Engineering 2015; 1:249–253.
• 3. Ferguson RM, Khandhar AP, Hamed A, Loc H, Hovorka O, Krishnan KM. Tailoring the magnetic and pharmacokinetic properties of iron oxide magnetic particle imaging tracers. Biomedical Engineering/Biomedizinische Technik 2013; 58(6): 493–507.
• 4. Jürgen Rahmer, Jürgen Weizenecker, Bernhard Gleich and Jörn Borgert. Signal encoding in magnetic particle imaging: properties of the system function. BMC Medical Imaging 2009, 9:4 doi:10.1186/1471-2342-9-4.
• 5. Thorsten M. Buzuga,∗, Gael Bringouta, Marlitt Erbea, Ksenija Gräfea, Matthias Graesera, Mandy Grüttnera, Aleksi Halkolaa, Timo F. Sattel a, Wiebke Tennera, Hanne Wojtczyka, Julian Haegele b, Florian M. Vogtb,Jörg Barkhausenb, Kerstin Lüdtke-Buzuga,Magnetic particle imaging: Introduction to imaging and hardware realization. Z. Med. Phys. 22 (2012) 323–334 http://dx.doi.org/10.1016/j.zemedi.2012.07.004, http://journals.elsevier.de/zemedi
• 6. S. Biederer, T. Sattel, T. Knopp, K. Lüdtke-Buzug,B. Gleich, J., Weizenecker, J. Borgert, T.M. Buzug, A Spectrometer for Magnetic Particle Imaging. ECIFMBE 2008, IFMBE Proceedings 22, pp. 2313–2316, 2008
• 7. S. Biederer, T. Sattel, T. Knopp, K. Lüdtke-Buzug,B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug, A Spectrometer for Magnetic Particle Imaging. ECIFMBE 2008, IFMBE Proceedings 22, pp. 2313–2316, 2008
• Web pages
• 8. Magnetic particle spectroscopy. http://www.nanomag-project.eu/magnetic-particle-spectroscopy.html
• 9. XR-2206 Monolithic Function Generator. https://www.sparkfun.com/datasheets/Kits/XR2206_104_020808.pdf
• 10. TDA2050 32 W hi-fi audio power amplifier. http://www.alldatasheet.com/datasheet-pdf/pdf/25046/STMICROELECTRONICS/TDA2050.html
• 11. Active Filters - Characteristics, Topologies and Examples, http://sound.whsites.net/articles/active-filters.htm
• 12. Operational transconductance amplifier, https://en.wikipedia.org/wiki/Operational_transconductance_amplifier
• 13. Slawomir Tumanski, Induction Coil Sensors – a Review. http://www.tumanski.x.pl/coil.pdf