Synthesis of Carbothioamide Substituted Benzimidazole Compounds and Investigation of Biological Activities

Year 2024, Volume: 6 Issue: 1, 1 - 15, 30.04.2024

Taner İlker Gümrükçüoğlu , Hakan Akgün , Bahar Bilgin Sökmen , Hakan Bektaş

https://doi.org/10.46740/alku.1340210

Abstract

Heterocyclic compounds containing nitrogen along with an oxygen atom in their structure are a major class of medicinal chemistry compounds due to their diverse biological applications. Benzimidazoles is also a heterocyclic aromatic organic compound in this group, carrying two different nitrogen (N) atoms in the ring structure. In this study, the antiurease and antioxidant activities of the synthesized benzimidazole derivatives (1-5) were investigated by spectrophotometric methods. Evidence of antioxidant activity clearly shows us that there is a defense mechanism against diseases that may occur in the body. All synthesized benzimidazole compounds showed antiurease and antioxidant activity. The most potent compound showing urease inhibition activity is number 2, and the least active compound is compound number 4. All compounds showed higher activity than thiourea. The compound with the highest antioxidant activity was determined as compound number 5, and the compound with the lowest antioxidant activity was determined as compound number 4.

Keywords

ABTS and DPPH activity, Antiurease activity, Antioxidant activity, Benzimidazole

Project Number

FEN-BAP-C-230123-03

Karbotiyoamidin Sübstitüye Benzimidazol Bileşiklerinin Sentezi ve Biyolojik Aktivitelerinin İncelenmesi

Abstract

Yapılarında bir oksijen atomu ile birlikte nitrojen içeren heterosiklik bileşikler, çeşitli biyolojik uygulamaları nedeniyle önemli bir tıbbi kimya bileşikleri sınıfıdır. Benzimidazoller de bu grupta yer alıp, halka yapısında farklı yapıda iki azot (N) atomu taşıyan heterosiklik bir aromatik organik bileşiktir. Yapılan bu çalışmada, sentezlenen benzimidazol türevlerinin (1-5) antiüreaz ve antioksidan aktiviteleri spektrofotometrik metotlarla incelendi. Antioksidan aktivitesinin kanıtı bizlere vücutta oluşabilecek hastalıklara karşı savunma mekanizmasının var olduğunu açıkça göstermektedir. Sentezlenen tüm benzimidazol bileşikleri antiüreaz ve antioksidan aktivite gösterdi. Üreaz inhibisyon aktivitesi gösteren en güçlü bileşik 2 numaralı, en az aktif bileşik ise 4 numaralı bileşiktir. Tüm bileşikler tiyoüreden daha yüksek aktivite gösterdi. En yüksek antioksidan aktivitesine sahip bileşik 5 numaralı bileşik, en düşük antioksidan aktivitesine sahip bileşik ise 4 numaralı bileşikler olarak belirlendi.

Keywords

ABTS ve DPPH aktivitesi, Antiüreaz aktivite, Antioksidan aktivite, Benzimidazol

Supporting Institution

Giresun Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

FEN-BAP-C-230123-03

Thanks

Yazarlar olarak bu çalışmayı FEN-BAP-C-230123-03 proje numarasıyla desteklemiş olan Giresun Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi’ne, makalenin inceleme ve değerlendirme aşamalarındaki tüm katkılardan dolayı editör ve hakemlere teşekkür ederiz.

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