Leukocyte Count as Chronic Inflammation Markers in Type 2 Diabetes Patients

Year 2017, Volume: 17 Issue: 4, 253 - 259, 20.12.2017

Esra Durmuş Cenk Aypak , Süleyman Görpelioğlu

https://doi.org/10.17098/amj.364164

Cited By: 1

Abstract

Objectives:
Epidemiological studies have revealed an association between higher total
peripheral white blood cells (WBC) count and Type 2 Diabetes Mellitus (T2DM).
However, the association has not been systematically investigated. The aim of
this study was to compare peripheral leukocyte count and biochemical test
results in diabetic and non–diabetic patients.
Materials and Methods: The study was
conducted among the patients had been followed by Family Medicine Outpatient
Clinics of Dışkapı Yıldırım Beyazıt Training and Research Hospital between
02.02.2015-30.09.2015. Patients anthropometric measurements, complete blood
cell count and biochemical tests’ results were recorded and these values were
compared between two groups (T2DM(+) and T2DM(-)).
Results: A total of 286 patients
(mean age: 58.7±10.5 years) were enrolled. There were no differences in age and
sex distribution between T2DM(+) (n=108) and T2DM (-) (n=178) groups. In
T2DM(+) group, leukocyte count was found to be higher than T2DM(-) group (7.73
× 103/ml; 7.17 × 103/ml; p=0.001). Waist circumference, body mass index,
fasting blood glucose, alanine amino transferase and triglycerides levels were
also found to significantly higher in T2DM(+) group. Conversly, high density
lipoprotein and low-density lipoprotein levels were found to be significantly
lower in T2DM(+) group. 
Conclusion: Leukocyte count, even
within normal range, was higher in T2DM patients compared to non-diabetic
individuals. Our results support the role of chronic inflammation in T2DM.
There is a need for comprehensive studies to explain the role of inflammation
in diabetes.

Keywords

Inflammation, diabetes, leukocyte count

Tip 2 Diyabet Hastalarında Kronik İnflamasyon Belirteci Olarak Lökosit Sayımı

Abstract

Amaç: Epidemiyolojik
araştırmalar periferik kandaki lökosit sayısı ile Tip 2 Diyabetes Mellitus
(T2DM) arasında ilişki bulunduğunu göstermesine rağmen bu ilişki sistematik
olarak incelenmemiştir. Bu çalışmada, T2DM tanısı olan hastaların (T2DM(+))
lökosit sayımı ve biyokimya tetkik sonuçlarının diyabeti olmayan hastaların
(T2DM(-)) sonuçlarıyla karşılaştırılması amaçlanmıştır.

Materyal ve Metot: Çalışmaya;
02.02.2015-30.09.2015 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve
Araştırma Hastanesi Aile Hekimliği Poliklinikleri’ne başvuran hastalar
alınmıştır. Hastaların antropometrik ölçümleri, tam kan sayımı ve biyokimyasal
testlerinin sonuçları kaydedilmiştir ve bu değerler T2DM(+) ile T2DM(-)
grupları arasında karşılaştırılmıştır.

Bulgular: Çalışmaya dâhil
edilen 286 hastanın yaş ortalaması 58,7±10,5 yıl olarak saptandı. T2DM(+)
(n=108) ve T2DM(-) (n=178) gruplarının yaş ve cinsiyet dağılımları arasında
fark yoktu. T2DM(+) grubun ortalama lökosit sayısının T2DM(-) grubundan yüksek
olduğu saptandı (7,73 × 103/ml; 7,17 × 103/ml; p=0,001). T2DM(+) grubun bel
çevresi, vücut kitle indeksi (VKİ), açlık kan şekeri (AKŞ), alanin
aminotransferaz (ALT) ve trigliserid değerleri T2DM(-) grubuna göre anlamlı
olarak yüksek olduğu, düşük yoğunluklu kolesterol (LDL) ve yüksek yoğunluklu
kolesterol (HDL) değerlerinin ise anlamlı olarak daha düşük olduğu
bulundu. 

Sonuç: Lökosit sayısı normal
sınırlar içerisinde dahi T2DM hastalarında diyabeti olmayan bireylerden daha
yüksektir. Bizim sonuçlarımız kronik inflamasyonun Tip 2 diyabetteki rolünü
desteklemektedir. İnflamasyonun diyabetteki rolünü açıklayacak daha kapsamlı
çalışmalara ihtiyaç vardır.

Keywords

İnflamasyon, diyabet, lökosit sayımı

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