Evaluation of Hematological Parameters and Iron Level in Obese Children and Adolescents

Year 2019, Volume: 19 Issue: 3, 479 - 487, 30.09.2019

Cemile Ece Çağlar Şimşek , Nurullah Çelik Utku Aygüneş Amine Yavuz Dönmez Ezgi Avcı Mahmut Ekici

https://doi.org/10.17098/amj.624400

Cited By: 1

Abstract

Objectives: The aim of the
study was to investigate hematological parameters and iron level in obese
children and adolescents in different age groups.

Materials and Methods: The study
population consisted of hundred-fifty four obese children and adolescents aged
between 3 and 18 years, who were being followed at the Cumhuriyet University
Faculty of Medicine Hospital, Pediatric Endocrinology Clinic. As the control
group, 158 healthy age and sex-matched children were also included. The
children were divided into three groups according to age: Group 1 (3-7 years),
Group 2 (7-12 years), and Group 3 (12-18 years). Hematological parameters,
serum iron, total iron-binding capacity, and ferritin levels were compared, and
their correlations with body mass index(BMI) were investigated.

Results: The mean ages of the
control (10,66±3,40; %55,80 girls) and case (10± 4,16; %62 girls) groups were
similar. When compared serum iron, total iron-binding capacity, transferrin
saturation and ferritin levels, in obese children aged between 12-18 years,
serum iron and transferrin saturation was lower whereas ferritin level and
total iron-binding capacity were higher (p<0,001). On the other hand, the
ferritin level and total iron-binding capacity were higher in obese children
aged between 7-12 years, while the other parameters were similar. When the
correlations between BMI-SDS and hematological parameters were evaluated;
positive correlations with white blood cell count (r = 0.46, p< 0.001),
absolute neutrophil count (r = 0.40, p< 0.001) and ferritin levels (r =
0.36, P <0.001), while a negative correlation with transferrin saturation
percentage (r = -0.22, p = 0.02) were found.

Conclusion: Obese adolescents are
prone to iron deficiency with low saturation index. Therefore ferritin level
may be misled for investigating iron deficiency status in obese adolescents

Keywords

Children, Obesity, Iron deficiency, ferritin

Obez Çocuk ve Adolesanlarda Hematolojik Parametreler ve Demir Düzeyinin Değerlendirilmesi

Abstract

Amaç: Bu çalışmanın amacı farklı yaş gruplarındaki obez çocuk ve
adolesanlarda hematolojik parametreler ve demir düzeylerini araştırmaktır.

Materyal ve Metot: Bu çalışmaya Cumhuriyet Üniversitesi Tıp Fakültesi, Çocuk
Endokrinoloji Polikliniğinde takip edilen, 3-18 yaş arası yüz ellidört çocuk ve
adolesan dahil edilmiştir. Kontrol grubu olarak ise, yaş ve cinsiyetleri
benzer, sağlıklı 158 çocuk alınmıştır. Çocuklar yaş gruplarına göre, Grup 1
(3-7 yaş), Grup 2 (7-12 yaş) ve Grup 3 (12-18 yaş) olmak üzere 3’e ayrıldı.
Hematolojik parametreler, serum demir, demir bağlama kapasitesi(FeBK) ve
ferritin düzeyleri karşılaştırıldı, Vücut Kitle İndeksi(VKI) ile olan
korelasyonları araştırıldı.

Bulgular: Kontrol
(10,66±3,40; %55,8 kız) ve vaka (10± 4,16; %62 kız) gruplarında yaş ortalamalrı
benzerdi. Serum demir, FeBK, transferrin saturasyonu ve ferritin düzeyleri
karşılaştırıldığında ise 12-18 yaş grubunda, obez çocuklarda, serum demiri ve
transferrin saturasyonu daha düşükken, ferritin düzeyi ve FeBK daha yüksekti
(p<0,001). 7-12 yaş grubunda ise obez çocuklarda ferritin düzeyi ve FeBK
daha yüksekken diğer parametreler benzerdi. Vücut kitle indeksi standart sapma
(VKI-SDS) ile hematolojik parametrelerin korelasyonları karşılaştırıldığında,
VKI-SDS Beyaz Küre Sayısı (r=0,46, p<0,001), Absolü Nötrofil Sayısı (r=0,40,
p<0.001) ve Ferritin (r=0,36, p<0,001) ile pozitif korelasyon
gösterirken, Transferrin Saturasyon Yüzdesi ile negatif bir korelasyon (
r=-0,22, p=0,02 ) gösteriyordu.

Sonuç: Obez
adolesanlar düşük saturasyon indeksi nedeni ile demir eksikliğine yatkındırlar.
Obezlerde demir durumu araştırılırken ferritin düzeyi tek başına yanıltıcı
olabilir.

Keywords

Çocuklar, obezite, demir eksikliği, ferritin

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