Preeklamptik gebeliği olan kadınlara verilen planlı eğitimin oksidatif stres ve anksiyete düzeylerine etkisi nasıldır?: randomize olmayan kontrollü çalışma

Year 2021, Volume: 5 Issue: 3, 597 - 608, 30.09.2021

Emel Taşçı Duran , Serdal Öğüt , Mehmet Okan Özkaya

https://doi.org/10.46237/amusbfd.953786

Abstract

Amaç: Bu çalışma, preeklamptik gebeliği olan kadınlara verilen planlı eğitimin stres-anksiyete ve oksidatif stres düzeylerine etkisini araştırmayı amaçlamıştır.
Yöntem: Bir üniversitenin Araştırma ve Uygulama Hastanesinde yürütülen randomize olmayan kontrollü bir çalışmadır. Kontrol grubu için anket, ölçek uygulaması ve laboratuvar değerlendirmesi sadece bir kez yapılmıştır.
Bulgular: Çalışmada preeklampsi tanısı alan gebelere verilen planlı eğitimin oksidatif stres düzeylerini ve durumluk kaygı düzeylerini azalttığı belirlendi.
Sonuç: Preeklampsi hastalarına bakım ve tedavinin yanı sıra, hastalık bilgilendirme eğitimi ve psikolojik desteğin verilmesinin hastalığın tedavisinde olumlu bir gelişme yaratacağı düşünülmektedir.

Keywords

Preeklampsi, Anksiyete, Oksidatif stres.

Supporting Institution

yoktur

Project Number

yoktur

Thanks

çalışamaya katılan gebe kadınlara teşekkür ederiz.

How is the effect of planned training given to women with preeclamptic pregnancy on oxidative stress and anxiety levels?: non-randomised controlled-study

Abstract

Objective: This study aimed to studying the effects of planned training given to women with preeclamptic pregnancy on stress-anxiety and oxidative stress levels.
Method: A non-randomised controlled-study, carried out in Research and Application Hospital of one university. Questionnaire, scale application and laboratory evaluation for the control group were performed only once.
Results: It has been determined in the study that the planned training given to the pregnant women who received a diagnosis of preeclampsia has decreased their oxidative stress levels and state anxiety levels.
Conclusion: In addition to care and treatment for preeclampsia patients, it is thought that providing disease information education and psychological support will create a positive development in the treatment of the disease.

Keywords

Pre-eclampsia, Anxiety, Oxidative stress

Project Number

yoktur

References

• 1. Amaral, L.M., Wallace, K., Owens, M., &LaMarca, B. (2017). Pathophysiology and current clinical management of preeclampsia. Current Hypertension Report, 19(8), 61. https://doi.org/10.1007/s11906-017-0757-7
• 2. Hassan, S.I., Gouda, A.M.I., El-Monshed, A., &Kandeel, H.A.M. (2020). Effect of Cognitive Behavioral Therapy on Anxiety, Stress, Depression, and Coping Pattern among Pregnant Women with Preeclampsia. American Journal of Nursing Research, 8(2), 269-277 https://doi.org/10.12691/ajnr-8-2-16
• 3. Agrawal, S., Gagandeep, K. W., Staines-Urias, E., Casas, J.P., & Millett C. (2017). Prevalence of and risk factors for eclampsia in pregnant women in India. Family Medicine and Community Health, 4(1), 225-244(20) https://doi.org/10.15212/FMCH.2016.0121
• 4. Maaliki, D., Issa, K., Shehabi, T.A., El-Yazbi, A., & Eid AH. (2019). The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis Microcirculation, 26:e12511. https://doi.org//10.1111/micc.12511
• 5. Liu, M. Y., Li, N., Li, W. A., & Khan, H. (2017). Association between psychosocial stress and hypertension: a systematic review and meta-analysis. Neurological research, 39(6), 573–580. https://doi.org/10.1080/01616412.2017.1317904
• 6. Giannakou, K., Evangelou, E.,& Papatheodorou, S.I. (2018). Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of systematic reviews and meta-analyses of observational studies. Ultrasound Obstetrics Gynecology, 51, 720–730. https://doi.org/10.1002/uog.18959
• 7. Lackner, H. K., Moertl, M. G., Schmid-Zalaudek, K., Lucovnik, M., Weiss, E. M., Kolovetsiou-Kreiner, V., & Papousek, I. (2018). History of Preeclampsia Adds to the Deleterious Effect of Chronic Stress on the Cardiac Ability to Flexibly Adapt to Challenge. Frontiers in physiology, 9, 1237. https://doi.org/10.3389/fphys.2018.01237
• 8. Yi, Y., Jing, Y., Gang, Z., & Weiwei, X. (2017). Potential risk factor of pre-eclampsia among healthy Chinese women: a retrospective case control study. Biomedical Research, 2017, 28 (3), 1183-1188.
• 9. Staneva, A., Bogossian, F., Pritchard, M., & Wittkowski, A. (2015). The effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: A systematic review. Women and Birth, 28(3), 179-193. https://doi.org/10.1016/j.wombi.2015.02.003
• 10. Thombre, M. K., Talge, N. M., & Holzman, C. (2015). Association between pre-pregnancy depression/anxiety symptoms and hypertensive disorders of pregnancy. Journal of women's health (2002), 24(3), 228–236. https://doi.org/10.1089/jwh.2014.4902
• 11. Phipps, E., Prasanna, D., Brima, W., & Jim, B. (2016). Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines. Clinical journal of the American Society of Nephrology : CJASN, 11(6), 1102–1113. https://doi.org/10.2215/CJN.12081115
• 12. Ferguson, K.K., Meeker, J.D., McElrath, T.F., Mukherjee, B.,& Cantonwine, D.E. (2017). Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal of obstetrics Gynecology, 216, 527.e1-9. https://doi.org/10.1016/j.ajog.2016.12.174
• 13. D'Souza, V., Rani, A., Patil, V., Pisal ,H., Randhir, K., Mehendale, S., &…….Joshi, S. (2016). Increased oxidative stress from early pregnancy in women who develop preeclampsia. Clinical and Experimental Hypertension, 38(2), 225-232. https://doi.org/10.3109/10641963.2015.1081226
• 14. Aouache, R., Biquard, L., Vaiman, D., & Miralles F. (2018). Oxidative stress in preeclampsia and placental diseases, International Journal of Molecular Sciences, 19(5), 1496. https://doi.org/10.3390/ijms19051496
• 15. Ahmad, I.M., Zimmerman, M.C.,& Moore, T.A. (2019). Oxidative stress in early pregnancy and the risk of preeclampsia. Pregnancy. Hypertension, 18, 99-102. https://doi.org/10.1016/j.preghy.2019.09.014
• 16. Ferreira, R.C., Tenório-Fragoso, M.B., Bueno, N.B., Fonseca Goulart, M.O., & Menezes de Oliveira, A.C. (2020). Oxidative stress markers in preeclamptic placentas: A systematic review with meta-analysis. Plasenta, 99, 15, 89-100. https://doi.org/10.1016/j.placenta.2020.07.023
• 17. Picard, M., & McEwen, B.S. (2018). Psychological stress and mitochondria: A Systematic Review. Psychosomatic Medicine, 80 (2), 141-153 https://doi.org/i: 10.1097/PSY.0000000000000545
• 18. Salim S. (2016). Oxidative stress: a potential link between emotional wellbeing and immune response. Current opinion in pharmacology, 29, 70–76. https://doi.org/10.1016/j.coph.2016.06.006
• 19. Davinelli, S., &De Vivo, I. (2019). Lifestyle Choices, Psychological Stress and Their Impact on Ageing: The Role of Telomeres. In: Caruso C. (eds) Centenarians. Springer, Cham. https://doi.org/10.1007/978-3-030-20762-5_8
• 20. Sies, H., & Jones, D. P. (2020). Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature reviews. Molecular cell biology, 21(7), 363–383. https://doi.org/10.1038/s41580-020-0230-3
• 21. Erer, MT. (2004). Care of pregnant women with preeclampsia and state anxiety of influence on knowledge related [thesis]. Mersin, Turkey: Mersin University.
• 22. Erer, M.T., &Akan, N. (2008). Effect of pregnant women's knowledge about care and Informatıon about preeclampsia on their level of State anxiety. Journal of Anatolia Nursing and Health Sciences, 11(3), 51-58. https://doi.org/10.17049/ahsbd.84425
• 23. Chao-Min, L. (2018). The effect of health education and mental nursing on the anxiety of patients with mild preeclampsia. Nursing Practice and Research, 13. Available from: http://en.cnki.com.cn/Article_en/CJFDTotal-HLSJ201113065.htm. Accessed in 2018 (Jul 20).
• 24. Erel, O. A. (2004). Novel automated method to measure total antioxidant response against potent free radicals reactions. Clinical Biochemical, 37, 112–119. https://doi.org/10.1016/j.clinbiochem.2003.10.014
• 25. Erel, O. A. (2005). Novel automated colorimetric method for measuring total oxidant status. Clinical Biochemical, 38, 1103–1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
• 26. Mannaerts, D., Faes, E., Cos, P., Briedé, J. J., Gyselaers, W., Cornette, J., Gorbanev, Y., Bogaerts, A., Spaanderman, M., Van Craenenbroeck, E., & Jacquemyn, Y. (2018). Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PloS one, 13(9), e0202919. https://doi.org/10.1371/journal.pone.0202919
• 27. Hodzic, J., Izetbegovic, S., Muracevic, B., Iriskic, R., & Stimjanin Jovic, H. (2017). Nitric oxide biosynthesis during normal pregnancy and pregnancy complicated by preeclampsia. Medicinski Glasnik (Zenica), 14(2), 211–7. https://doi.org/10.17392/915-17
• 28. Kurdoglu, Z., Ozkol, H., Kurdoglu, M., & Kamaci M. (2012). Evaluation of the relationship between adenosine deaminase, myeloperoxidase, cho- linesterase, preeclampsia severity, and neonatal outcomes. Clinical Experimental Hypertension, 34, 493–497. https://doi.org/10.3109/10641963.2012.666605.
• 29. Shehu, C.E., Ekele, B.A., Suleman, B.L., Panti, A.A., Eze, U.A,, Burodo, A.T.,&.. Suleiman B. A (2020). Comparative Study of Oxidative Stress in Preeclampsia and Normal Pregnancy Sch International Journal of Obstetrics Gynecology, 3(4), 127-133 https://doi.org/10.36348/sijog.2020.v03i04.004
• 30. Kharb, S. (2000). Vitamin E and C in pre-eclampsia. Europian Journal of Obstetrics Gynecology Reproductive Biology, 93(1), 37-39. https://doi.org/10.1016/S0301-2115(00)00243-8.
• 31. Turpin, C.A., Sakyi, S.A., Owiredu, W.K.B.A., Ephraim, R.K.D, & Anto, EO.(2015). Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia. BMC Pregnancy Childbirth, 15(189),1-10. https://doi.org/10.1186/s12884-015-0624-y.
• 32. Scarpellini, F., Sbracia, M., & Scarpellini, L. (1994). Psychological stress and lipoperoxidation in miscarriage. Annals of the New York Academy of Sciences, 709, 210–213. https://doi.org/10.1111/j.1749-6632.1994.tb30404.x
• 33. Schneider, R. H., Nidich, S. I., Salerno, J. W., Sharma, H. M., Robinson, C. E., Nidich, R. J., & Alexander, C. N. (1998). Lower lipid peroxide levels in practitioners of the Transcendental Meditation program. Psychosomatic medicine, 60(1), 38–41. https://doi.org/10.1097/00006842-199801000-00008
• 34. Thilaganathan, B.,& Kalafat, E. (2019). Cardiovascular system in preeclampsia and beyond. Hypertension, 73(3), 522-531 https://doi.org/10.1161/HYPERTENSIONAHA.118.11191
• 35. Sarmasti, N., Ayoubi, S. H., Mahmoudi, G., & Heydarpour, S. (2019). Comparing Perceived Social Support and Perceived Stress in Healthy Pregnant Women and Pregnant Women with Preeclampsia. Ethiopian journal of health sciences, 29(3), 369–376. https://doi.org/10.4314/ejhs.v29i3.9
• 36. Damayanti, S., Sulistyowati, S., &Probandari, N. A. (2019). Maternal characteristics and the effects of early and late-onset types of preeclampsia on maternal and perinatal complications. Indonesian Journal of Medicine, 4(4), 329-33https://doi.org/10.26911/theijmed.2019.04.04.05
• 37. Caplan, M., Keenan-Devlin, L. S., Freedman, A., Grobman, W., Wadhwa, P. D., Buss, C., Miller, G. E., & Borders, A. (2020). Lifetime Psychosocial Stress Exposure Associated with Hypertensive Disorders of Pregnancy. American journal of perinatology, 10.1055/s-0040-1713368. Advance online publication. https://doi.org/10.1055/s-0040-1713368
• 38. Valsamakis, G., Chrousos, G., & Mastorakos, G. (2019). Stress, female reproduction and pregnancy. Psychoneuroendocrinology. 2019,100, 48-57 https://doi.org/10.1016/j.psyneuen.2018.09.031
• 39. Kordi, M., Vahed, A., Rezaee Talab, F., Mazloum, S.R.,& Lotfalizadeh M. (2017). Anxiety during Pregnancy and Preeclampsia: A Case-Control Study. Journal of Midwifery and Reproductive Health, 5(1), 814-820. https://doi.org/10.22038/JMRH.2016.7881
• 40. Feroz, A., Saleem, S., & Seto, E. (2020). Exploring perspectives, preferences and needs of a telemonitoring program for women at high risk for preeclampsia in a tertiary health facility of Karachi: a qualitative study protocol. Reproductive Health, 17, 135 https://doi.org/10.1186/s12978-020-00979-8