Can Long-term Antifungal Therapy Be an Alternative to Surgery in Pulmonary Aspergilloma?

Year 2018, Volume: 23 Issue: 3, 189 - 194, 26.09.2018

H.volkan Kara , Ezel Ersen Mehlika Iscan İsmail Sarbay , Merve Ekinci Akif Turna

https://doi.org/10.21673/anadoluklin.413147

Abstract

Pulmonary aspergilloma is one of the clinical conditions with high mortality and morbidity
in immunosuppressed patients. Surgical resection has been the leading treatment option;
however, surgical treatment involves some risk of local and systemic dissemination and
there are also patients who are functionally inappropriate to be treated surgically. In this
paper, we present two patients with bilateral PA who underwent surgical and antifungal
treatment. Antifungal therapy with voriconazole that was successful for both of our patients
might be a promising approach to a group of PA patients who are not appropriate
for surgery

Keywords

pulmonary, aspergilloma, voriconazole, surgery, fungus ball

Pulmoner Aspergillomada Uzun Dönem Antifungal Tedavi Cerrahiye Alternatif Olabilir mi?

Abstract

Pulmoner aspergilloma (PA), immünsüprese hastalarda yüksek mortalite ve morbiditeli
klinik durumlardandır. Tedavide sıklıkla cerrahi rezeksiyon tercih edilir; fakat cerrahide lokal
ve sistemik yayılım riski mevcuttur ve ayrıca cerrahi tedaviye fonksiyonel olarak uygun
olmayan hastalar da vardır. Bu çalışmada cerrahi ve antifungal tedavi uygulanmış olan
bilateral PA’lı iki hastayı sunmaktayız. Vorikonazol ile yapılan ve iki hastamızda da başarılı
olan antifungal tedavi, cerrahiye uygun olmayan bir grup PA hastası için ümit verici bir
yaklaşım olabilir. 

Keywords

pulmoner aspergilloma, vorikonazol, cerrahi, mantar topu

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