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A Retrospective Review of Patients Hospitalized in the Postoperative Intensive Care Unit due to Ectopic Pregnancy Rupture

Year 2020, Volume: 25 Issue: 1, 44 - 50, 15.01.2020
https://doi.org/10.21673/anadoluklin.591224

Abstract

Aim:
In this study, we
aimed to retrospectively review the clinical characteristics of patients who
were operated on for ectopic pregnancy rupture (EPG) in our hospital and hospitalized
in the postoperative intensive care unit (ICU) and evaluate the possible
relations between the patient laboratory data and ICU length of stay.

Materials
and Methods:
The study
included 56 female patients whose medical records were available and who were
hospitalized in the ICU between 1.1.2017 and 1.1.2019. We retrospectively recorded
the patients’ demographic and clinical characteristics and laboratory data, amount
of blood and blood products received, and number of days spent in the ICU.

Results:
The mean patient age
was 30.21±5.26 years and the mean ICU length of stay was 1.87±1.20 days. The patients
were given an average of 1.78±1.76 units of erythrocyte suspension (EU), 1.19±1.55
U fresh frozen plasma (FFP), and 0.03±0.26 U platelet suspension (PS). It was
found that between the ICU length of stay and the hematocrit and platelet
values, hemoglobin values, ES and FFP use, and PS use there was a weak negative
(r=-0.388, p=0.003; r=-0.380, p=0.004), moderate negative (r=-0.436, p=0.001), moderate
positive
(r=0.469, p<0.001; r=0.476,
p<0.001)
, and weak
positive (r=0.281, p=0.036) correlation, respectively. It was also found that the patients who received blood and blood
products replacement stayed in the ICU longer than those who did not receive a replacement
(p=0.004).







Discussion
and Conclusion:
We found a
statistically significant negative correlation between the low hemoglobin,
hematocrit, and platelet values and the ICU length of stay. There was a statistically
significant positive correlation between the amount of ES, FFP, and PS given to
the patients and the ICU length of stay. It was also observed that the patients
who received more blood and blood products stayed longer in the ICU.

References

  • Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J, et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Heal. 2014;2(6):323–33.
  • Zhang B, Cui L, Tang R, Ding L, Yan L, Chen ZJ. Reduced ectopic pregnancy rate on day 5 embryo transfer compared with day 3: A meta-analysis. PLoS One. 2017;12(1):1–14.
  • Kontomanolis EN, Kalagasidou S, Fasoulakis Z. MicroRNAs as potential serum biomarkers for early detection of ectopic pregnancy. Cureus. 2018;10(3):e2344.
  • Lawani OL, Anozie OB, Ezeonu PO. Ectopic pregnancy: a life-threatening gynecological emergency. Int J Womens Health. 2013;5:515–521.
  • Taran F, Kagan K, Hübner M, Hoopmann M, Wallwiener D, Brucker S. The diagnosis and treatment of ectopic pregnancy. Dtsch Arztebl Int. 2015;112:693–704.
  • Stremick J, Couperus K, Ashworth S. Ruptured tubal ectopic pregnancy at fifteen weeks gestational age. Clin Pract Cases Emerg Med. 2019;3(1):62–4.
  • O’Neill SM, Khashan AS, Kenny LC, Greene RA, Henriksen TB, Lutomski JE, et al. Caesarean section and subsequent ectopic pregnancy: A systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2013;120(6):671–80.
  • Della-Giustina D, Deny M. Ectopic pregnancy. Emerg Med Clin North Am. 2003;21:565–84.
  • Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015;1(1):1–20.
  • Neth M, Thompson M, Gibson C, Gullett J, Pigott D. Ruptured ectopic pregnancy in the presence of an intrauterine device. Clin Pract Cases Emerg Med. 2019;3(1):51–4.
  • Baker M, dela Cruz J. Ectopic Pregnancy, Ultrasound. [Updated 2019 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482192/
  • Rathore R, Shilpi S, Chopra R, Nargotra N. Primary splenic pregnancy- A rare but imperative cause of hemoperitoneum - Case report and review of literature. Turk Patoloji Derg. 2017;1(1):1–5.
  • Yang M, Cidan L, Zhang D. Retroperitoneal ectopic pregnancy: A case report and review of the literature. BMC Pregnancy Childbirth. 2017;17(1):1–4.
  • Beyazit F, Pek E, Çakır Güngör A, Gencer M, Uysal A, Hacıvelioğlu S, et al. Retrospective analysis of factors affecting the clinical course and treatment outcome of ectopic pregnancy. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 2017; 14(1): 9-12
  • Lozeau A. Diagnosis and management of ectopic pregnancy. Am Fam Physician. 2005;72(9):1707–14.
  • Uzundere O, Kaçar CK, Erdal Erbatur M, Kahveci B, Yektaş A. Retrospective analysis of the patients who admitted to intensive care unit after cesarean section in our hospital. Turkiye Klinikleri J Anest Reanim. 2018;16(3):77-83.
  • Krishna H, Chava M, Jasmine N, Shetty N. Patients with postpartum hemorrhage admitted in intensive care unit: Patient condition, interventions, and outcome. J Anaesthesiol Clin Pharmacol. 2011;27(2):192-4.
  • Wanderer JP, Leffert LR, Mhyre JM, Kuklina EV, Callaghan WM, Bateman BT. Epidemiology of obstetric-related ICU admissions in Maryland: 1999-2008. Crit Care Med. 2013;41(8):1844–52.
  • Lotufo FA, Parpinelli MA, Haddad SM, Surita FG, Cecatti JG. Applying the new concept of maternal near-miss in an intensive care unit. Clinics (Sao Paulo). 2012;67(3):225–30.
  • Chong MA, Krishnan R, Cheng D, Martin J. Should transfusion trigger thresholds differ for critical care versus perioperative patients? A meta-analysis of randomized trials. Crit Care Med. 2018;46(2):252–63.
  • Chen QH, Wang HL, Liu L, Shao J, Yu J, Zheng RQ. Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: A meta-analysis of randomized controlled trials. Crit Care. 2018;22(1):1–9.
  • Mao T, Gao F, Han J, Sun W, Guo W, Li Z, et al. Restrictive versus liberal transfusion strategies for red blood cell transfusion after hip or knee surgery: A systematic review and meta-analysis. Med (United States). 2017;96(25).
  • Whitlock RP, Khanykin B, Mistry N, Hwang N-C, Connolly K, Fremes S, et al. Six month outcomes after restrictive or liberal transfusion for cardiac surgery. N Engl J Med. 2018;379(13):1224–33.
  • Huang Y, Liang Y, Ma H, Ling M, Ran X, Huang J, et al. Restrictive Transfusion Strategy Does Not Affect Clinical Prognosis in Patients with Ectopic Pregnancy. BioMed Research International. 2017; 2679148:1-9. https://doi.org/10.1155/2017/2679148

Ektopik Gebelik Rüptürü Nedeniyle Postoperatif Yoğun Bakım Ünitesine Alınan Hastalar Üzerine Bir Retrospektif İnceleme

Year 2020, Volume: 25 Issue: 1, 44 - 50, 15.01.2020
https://doi.org/10.21673/anadoluklin.591224

Abstract

Amaç: Bu çalışmada, hastanemizde ektopik gebelik rüptürü (EGR)
nedeniyle acilen opere edilen
ve sonrasında postoperatif yoğun
bakım ünitesine (YBÜ) alınan hastaların klinik özelliklerini incelemek ve
laboratuvar verileri ile YBÜ’de kalış süresi arasındaki olası ilişkileri retrospektif
olarak değerlendirmek amaçlanmıştır.

Gereç ve Yöntemler: Çalışmaya dosya verilerine ulaşılabilen ve
1.1.2017—1.1.2019 döneminde
YBÜ’de yatmış olan 56 kadın hasta
dahil edildi. Hastaların demografik ve klinik özellikleri, laboratuvar
verileri, aldıkları kan ve kan ürünü miktarları ile YBÜ’de kaldıkları gün sayısı
retrospektif olarak kaydedildi.

Bulgular: Ortalama
hasta yaşı
30,21±5,26 yıl, ortalama YBÜ’de kalış süresi 1,87±1,20 gün idi.
Hastalara ortalama 1,78±1,76 ünite
eritrosit
süspansiyonu (ES)
, 1,19±1,55 Ü taze
donmuş plazma
(TDP) ve 0,03±0,26 Ü trombosit
süspansiyonu
(TS) verildi. Hastaların YBÜ’de kalış
süresi ile hematokrit ve platelet değerleri, hemoglobin değeri, ES ve TDP kullanımı,
ve TS kullanımı arasında sırasıyla negatif yönlü zayıf (r=-0,388, p=0,003;
r=-0,380, p=0,004), negatif yönlü orta (r=-0,436, p=0,001), pozitif yönlü orta
(r=0,469, p<0,001; r=0,476, p<0,001), ve pozitif
yönlü zayıf (r=0,281, p=0,036) düzeyde korelasyon olduğu saptandı. Ayrıca kan
ve kan ürünleri replasmanı uygulanan hastaların replasman uygulanmayan hastalara
göre YBÜ’de daha uzun süre kaldığı saptandı (p=0,004).







Tartışma ve Sonuç: Düşük
hemoglobin, hematokrit ve platelet değerleri ile YBÜ’de kalış süresi arasında
negatif yönlü, istatistiksel olarak anlamlı korelasyon saptandı. Hastalara
verilen ES, TDP ve TS miktarıyla YBÜ’de kalış süresi arasında ise pozitif yönlü
istatistiksel olarak anlamlı korelasyon vardı. Ayrıca daha fazla kan ve kan
ürünleri alan hastaların, YBÜ’de daha uzun süre kaldığı saptandı.

References

  • Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J, et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Heal. 2014;2(6):323–33.
  • Zhang B, Cui L, Tang R, Ding L, Yan L, Chen ZJ. Reduced ectopic pregnancy rate on day 5 embryo transfer compared with day 3: A meta-analysis. PLoS One. 2017;12(1):1–14.
  • Kontomanolis EN, Kalagasidou S, Fasoulakis Z. MicroRNAs as potential serum biomarkers for early detection of ectopic pregnancy. Cureus. 2018;10(3):e2344.
  • Lawani OL, Anozie OB, Ezeonu PO. Ectopic pregnancy: a life-threatening gynecological emergency. Int J Womens Health. 2013;5:515–521.
  • Taran F, Kagan K, Hübner M, Hoopmann M, Wallwiener D, Brucker S. The diagnosis and treatment of ectopic pregnancy. Dtsch Arztebl Int. 2015;112:693–704.
  • Stremick J, Couperus K, Ashworth S. Ruptured tubal ectopic pregnancy at fifteen weeks gestational age. Clin Pract Cases Emerg Med. 2019;3(1):62–4.
  • O’Neill SM, Khashan AS, Kenny LC, Greene RA, Henriksen TB, Lutomski JE, et al. Caesarean section and subsequent ectopic pregnancy: A systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2013;120(6):671–80.
  • Della-Giustina D, Deny M. Ectopic pregnancy. Emerg Med Clin North Am. 2003;21:565–84.
  • Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015;1(1):1–20.
  • Neth M, Thompson M, Gibson C, Gullett J, Pigott D. Ruptured ectopic pregnancy in the presence of an intrauterine device. Clin Pract Cases Emerg Med. 2019;3(1):51–4.
  • Baker M, dela Cruz J. Ectopic Pregnancy, Ultrasound. [Updated 2019 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482192/
  • Rathore R, Shilpi S, Chopra R, Nargotra N. Primary splenic pregnancy- A rare but imperative cause of hemoperitoneum - Case report and review of literature. Turk Patoloji Derg. 2017;1(1):1–5.
  • Yang M, Cidan L, Zhang D. Retroperitoneal ectopic pregnancy: A case report and review of the literature. BMC Pregnancy Childbirth. 2017;17(1):1–4.
  • Beyazit F, Pek E, Çakır Güngör A, Gencer M, Uysal A, Hacıvelioğlu S, et al. Retrospective analysis of factors affecting the clinical course and treatment outcome of ectopic pregnancy. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 2017; 14(1): 9-12
  • Lozeau A. Diagnosis and management of ectopic pregnancy. Am Fam Physician. 2005;72(9):1707–14.
  • Uzundere O, Kaçar CK, Erdal Erbatur M, Kahveci B, Yektaş A. Retrospective analysis of the patients who admitted to intensive care unit after cesarean section in our hospital. Turkiye Klinikleri J Anest Reanim. 2018;16(3):77-83.
  • Krishna H, Chava M, Jasmine N, Shetty N. Patients with postpartum hemorrhage admitted in intensive care unit: Patient condition, interventions, and outcome. J Anaesthesiol Clin Pharmacol. 2011;27(2):192-4.
  • Wanderer JP, Leffert LR, Mhyre JM, Kuklina EV, Callaghan WM, Bateman BT. Epidemiology of obstetric-related ICU admissions in Maryland: 1999-2008. Crit Care Med. 2013;41(8):1844–52.
  • Lotufo FA, Parpinelli MA, Haddad SM, Surita FG, Cecatti JG. Applying the new concept of maternal near-miss in an intensive care unit. Clinics (Sao Paulo). 2012;67(3):225–30.
  • Chong MA, Krishnan R, Cheng D, Martin J. Should transfusion trigger thresholds differ for critical care versus perioperative patients? A meta-analysis of randomized trials. Crit Care Med. 2018;46(2):252–63.
  • Chen QH, Wang HL, Liu L, Shao J, Yu J, Zheng RQ. Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: A meta-analysis of randomized controlled trials. Crit Care. 2018;22(1):1–9.
  • Mao T, Gao F, Han J, Sun W, Guo W, Li Z, et al. Restrictive versus liberal transfusion strategies for red blood cell transfusion after hip or knee surgery: A systematic review and meta-analysis. Med (United States). 2017;96(25).
  • Whitlock RP, Khanykin B, Mistry N, Hwang N-C, Connolly K, Fremes S, et al. Six month outcomes after restrictive or liberal transfusion for cardiac surgery. N Engl J Med. 2018;379(13):1224–33.
  • Huang Y, Liang Y, Ma H, Ling M, Ran X, Huang J, et al. Restrictive Transfusion Strategy Does Not Affect Clinical Prognosis in Patients with Ectopic Pregnancy. BioMed Research International. 2017; 2679148:1-9. https://doi.org/10.1155/2017/2679148
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section ORIGINAL ARTICLE
Authors

Osman Uzundere 0000-0002-5968-4561

Cem Kıvılcım Kaçar This is me 0000-0002-0015-948X

Publication Date January 15, 2020
Acceptance Date November 4, 2019
Published in Issue Year 2020 Volume: 25 Issue: 1

Cite

Vancouver Uzundere O, Kaçar CK. Ektopik Gebelik Rüptürü Nedeniyle Postoperatif Yoğun Bakım Ünitesine Alınan Hastalar Üzerine Bir Retrospektif İnceleme. Anatolian Clin. 2020;25(1):44-50.

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