Case Report
BibTex RIS Cite

Smoking Crushed-Boiled Hyoscine Butylbromide Tablets as Drug Abuse

Year 2019, Volume: 2 Issue: 4, 22 - 24, 31.12.2019

Abstract

Aim


Hyoscine-N-butylbromide is a quaternary amonium compound with anticholinergic properties. It acts through nicotinic and muscarinic receptors. In this case report, we aimed to describe the patient who boiled hyoscine-n butyl bromide and used it as an inhaler in order to benefit from the hallucinogenic effect of hyosine butylbromide tablets.


Case


A 47-year-old male patient was admitted to the emergency department with agitation, hallucinations and blurred vision. He was not oriental and cooperative. GCS: 13 and was prone to sleep. During the follow-up of the emergency department, vital signs, liver and kidney function tests and electrolytes were normal. There was no evidence of hemorrhage or infarct on Computer Tomography (CT). About 6 hours after admission, the patient's general condition improved. In his physical examination, GCS was 15 and he did not complain of blurred vision. In his story, he stated that hyoscine-N-butylbromide tablets were powdered and heated in a metal container and inhaled the smoke, taking advantage of the hallucinogenic effect.


Conclusion

Hyoscine-N-butylbromide tablets should be evaluated for their nicotinic, muscarinic and hallucinogenic effects. It should be remembered that it can be prepared as an inhaler and abused by drug addicts. It should be considered that there may be different forms of tablets with narcotic effect. In addition to case presentations, extensive research is needed.

References

  • 1. Kara H,Göktaş MT. Acces Url: http://guncel.tgv.org.tr/journal/64/pdf/100425.pdf
  • 2. Bourdoumis A, Stasinou T, Papadopoulos G, and Buchholz N. (2014) The evidence for using hyoscine N-butylbromide (Buscopan) in ureteric obstruction, Int J Clin Pract. 2014(68);9:1174, Doi: 10.1111/ijcp.12506.
  • 3. Gülaçtı U, Polat H, Lök U,Aydın İ. The evaluation of patients with renal colic due to urinary tract stones in emergency department, Gaziantep Medical Journal 2016(22);1:22-6, Doi: 10.5578/GMJ.27961.
  • 4. Sinanoğlu O, Ekici S, Uraz M, Çubuk R, Renal colic diagnosis and treatment in Emergency Services. Maltepe Medical Journal 2010(2);2:55-8.
  • 5. Gülaçtı U, Birkan Z, Üstin C. Pelvic ectopic renal ürolitiazis, JAEMCR 2013; 4:70-2. Doi: 10.5505/jeamcr.2013.65477.
  • 6. Kummer S, Rickert A, Daldrup T, Mayatepek E. Abuse of the over-thecounter antispasmodic butylscopolamine for the home synthesis of psychoactive scopolamine, Eur J Pediatr. 2016(175);7:1019-21. Doi: 10.1007/s00431-015-2683-5.
  • 7. Kruger D, Michel K, Allam S, Weiser T, Demir IE, Ceyhan GO et al. Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine, Neurogastroenterol Motil. 2013(25);8:530-9. Doi: 10.1111/nmo.12156.
  • 8. Dyde R, Chapman A H, Gale R, Mackintosh A, Tolan D J M. Precautions to be taken by radiologists and radiographers when prescribing hyoscine-N-butylbromide, Clinical Radiology, Clin Radiol. 2008(63);7:739-43. Doi: 10.1016/j.crad.2008.02.008.
  • 9. Blakeborough A, Sheridan MB, Chapman AH. Complicationsof barium enema examinations: a survey of UK consultant radiologists 1992 to 1994. Clin Radiol. 1997 (52);2:142-8. Doi:10.1016/s0009- 9260(97)80108-0.
  • 10. M.Frascht, Schneider S, Schuman M, Wennig R. Formation of scopolamine from N-butyl-scopolamonium bromide in cigarettes, Journal of analytical toxicology, J Anal Toxicol. 2007(31);4:220-3. Doi:10.1093/jat/31.4.220.
  • 11. Jalali, Afshari R, Babaei A. Smoking Crushed Hyoscine/ Scopolamine Tablets as Drug Abuse, Journal Substance Use & Misuse, 2014(49);7:793-7. https://doi.org/10.3109/10826084.2014.880178.

Ezilmiş-Haşlanmış Hiyozin N-bütilbromid Tabletlerin İnhale Kullanımı

Year 2019, Volume: 2 Issue: 4, 22 - 24, 31.12.2019

Abstract

Amaç

Hiyozin-N-bütilbromid antikolinerjik özelliklere sahip bir kuarterner amonyum bileşiğidir. Nikotinik ve muskarinik reseptörler üzerinden etki eder. Bu vakamızda, Hiyozin-Nbütilbromid tabletlerinin halusinojenik etkisinden faydalanmak amacıyla Hiyozin-N-bütilbromidi kaynatıp inhaler olarak kullanan hastayı anlatmak amaçlandı.

Olgu

47 yaşında erkek hasta ajitasyon, halüsinasyon ve bulanık görme şikayeti ile acil servise başvurdu. Oryante ve koopere değildi. GKS:13 idi ve uykuya meyilli idi. Acil servis takipleri sırasında vital bulgularda, karaciğer, böbrek fonksiyon testlerinde ve elektrolitlerinde patolojik durum saptanmadı. Kranial bilgisayarlı tomografisi’nde de kanama veya enfarkt lehine bulgu saptanmadı. Başvurudan yaklaşık 6 saat sonra hastanın genel durumu düzeldi. Yapılan fizik muayenesinde GKS:15 idi ve görme bulanıklığı şikayetinin olmadığını belirtti. Hikayesinde Hiyozin-N-bütilbromid tabletlerini toz haline getirerek metal bir kap içerisinde ısıttığını ve dumanını inhale ederek halusinojenik etkisinden faydalandığını ifade etti.

Sonuç

Hiyozin-N-bütilbromid tabletleri nikotinik, muskarinik ve halusinojenik etkileri açısından değerlendirilmelidir. İnhaler olarak hazırlanabileceği, madde bağımlıları tarafından kötüye kullanılabileceği unutulmamalıdır. Bu şekilde narkotik etkiye sahip farklı tablet formları olabileceği düşünülmelidir. Vaka sunumlarının yanı sıra kapsamlı bir araştırmalara da ihtiyaç vardır.

References

  • 1. Kara H,Göktaş MT. Acces Url: http://guncel.tgv.org.tr/journal/64/pdf/100425.pdf
  • 2. Bourdoumis A, Stasinou T, Papadopoulos G, and Buchholz N. (2014) The evidence for using hyoscine N-butylbromide (Buscopan) in ureteric obstruction, Int J Clin Pract. 2014(68);9:1174, Doi: 10.1111/ijcp.12506.
  • 3. Gülaçtı U, Polat H, Lök U,Aydın İ. The evaluation of patients with renal colic due to urinary tract stones in emergency department, Gaziantep Medical Journal 2016(22);1:22-6, Doi: 10.5578/GMJ.27961.
  • 4. Sinanoğlu O, Ekici S, Uraz M, Çubuk R, Renal colic diagnosis and treatment in Emergency Services. Maltepe Medical Journal 2010(2);2:55-8.
  • 5. Gülaçtı U, Birkan Z, Üstin C. Pelvic ectopic renal ürolitiazis, JAEMCR 2013; 4:70-2. Doi: 10.5505/jeamcr.2013.65477.
  • 6. Kummer S, Rickert A, Daldrup T, Mayatepek E. Abuse of the over-thecounter antispasmodic butylscopolamine for the home synthesis of psychoactive scopolamine, Eur J Pediatr. 2016(175);7:1019-21. Doi: 10.1007/s00431-015-2683-5.
  • 7. Kruger D, Michel K, Allam S, Weiser T, Demir IE, Ceyhan GO et al. Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine, Neurogastroenterol Motil. 2013(25);8:530-9. Doi: 10.1111/nmo.12156.
  • 8. Dyde R, Chapman A H, Gale R, Mackintosh A, Tolan D J M. Precautions to be taken by radiologists and radiographers when prescribing hyoscine-N-butylbromide, Clinical Radiology, Clin Radiol. 2008(63);7:739-43. Doi: 10.1016/j.crad.2008.02.008.
  • 9. Blakeborough A, Sheridan MB, Chapman AH. Complicationsof barium enema examinations: a survey of UK consultant radiologists 1992 to 1994. Clin Radiol. 1997 (52);2:142-8. Doi:10.1016/s0009- 9260(97)80108-0.
  • 10. M.Frascht, Schneider S, Schuman M, Wennig R. Formation of scopolamine from N-butyl-scopolamonium bromide in cigarettes, Journal of analytical toxicology, J Anal Toxicol. 2007(31);4:220-3. Doi:10.1093/jat/31.4.220.
  • 11. Jalali, Afshari R, Babaei A. Smoking Crushed Hyoscine/ Scopolamine Tablets as Drug Abuse, Journal Substance Use & Misuse, 2014(49);7:793-7. https://doi.org/10.3109/10826084.2014.880178.
There are 11 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Hatice Şeyma Akça 0000-0003-2823-9577

Deniz Tengerek 0000-0001-6788-5534

Burcu Yılmaz This is me 0000-0002-6475-7614

Serkan Emre Eroğlu 0000-0002-3183-3713

Publication Date December 31, 2019
Published in Issue Year 2019 Volume: 2 Issue: 4

Cite

AMA Akça HŞ, Tengerek D, Yılmaz B, Eroğlu SE. Smoking Crushed-Boiled Hyoscine Butylbromide Tablets as Drug Abuse. Anatolian J Emerg Med. December 2019;2(4):22-24.