Retrospective Analysis of Factors Predicting Mortality in Heart Failure Patients with Preserved Ejection Fraction

Year 2024, Volume: 7 Issue: 2, 67 - 73, 29.06.2024

Fulya Odabaş , Şükriye Miray Kılınçer Bozgül , Devrim Bozkurt

https://doi.org/10.54996/anatolianjem.1473257

Abstract

Aim: Heart failure with preserved ejection fraction
(HFpEF) is an important health problem with high morbidity and mortality rates in clinical practice. This study aims to retrospectively analyze the factors affecting mortality in patients with HFpEF.

Material and Methods: In this retrospective study, 105 patients with HFpEF were analyzed. Demographic characteristics, clinical data and laboratory results of the patients were evaluated and factors that may have an effect on mortality were analyzed by univariate and multivariate logistic regression analyses. Statistical significance level was accepted as p<0.05.

Results: As a result of the analysis, the need for vasopressor support(p=0.004) and the need for hemodialysis (p=0.007) were significantly associated with mortality. In addition, laboratory markers such as high levels of N- terminal-pro-brain natriuretic peptide, C-Reactive Protein and Lactate dehydrogenase were also found to be associated with mortality risk. Multivariate logistic regression analysis showed that changes in Δ% Creatinine and Δ% Hemoglobin levels independently affected mortality risk ( p=0.042 and p=0.023, respectively).

Conclusion: Our study provides a comprehensive analysis of factors that increase the risk of mortality in patients with HFpEF. It reveals that the need for vasopressor support and hemodialysis, as well as certain laboratory markers, should be considered in the management of these patients. The findings emphasize that future research should examine these factors in more depth and tailor treatment strategies for patients with HFpEF accordingly.

Keywords

Mortality, Vasopressor, Heart Failure, Preserved Ejection Fraction

Ethical Statement

Ege Üniversitesi Hastanesi Etik Kurulu çalışmayı onaylamıştır ( 18-2/28 karar numarası ).

Korunmuş Ejeksiyon Fraksiyonlu Kalp Yetmezliği Hastalarında Mortaliteyi Belirleyen Faktörlerin Retrospektif Analizi

Abstract

Amaç: Korunmuş ejeksiyon fraksiyonlu kalp yetmezliği, klinik pratiğinde yüksek morbidite ve mortalite oranlarına sahip olmasıyla önemli bir sağlık sorunudur. Bu çalışma, korunmuş ejeksiyon fraksiyonlu kalp yetmezliği tanılı hastalarda mortaliteyi etkileyen faktörleri retrospektif olarak analiz etmeyi amaçlamaktadır.

Gereç ve Yöntem: Bu retrospektif çalışmada 105 hasta incelenmiştir. Hastaların demografik özellikleri, klinik verileri ve laboratuvar sonuçları değerlendirilmiş; mortalite üzerinde etkili olabilecek faktörler tek ve çok değişkenli lojistik regresyon analizleri ile analiz edilmiştir. İstatistiksel anlamlılık düzeyi p<0.05 olarak kabul edilmiştir.

Bulgular: Analiz sonucunda, vazopressor destek gereksinimi (p=0.004) ve hemodiyaliz ihtiyacı ( p=0.007) mortalite ile anlamlı olarak ilişkili bulunmuştur. Ayrıca, yüksek N-terminal-pro-brain natriüretik peptit, C-Reaktif Protein ve Laktat dehidrogenaz düzeyleri gibi laboratuvar belirteçlerinin de mortalite riski ile ilişkili olduğu tespit edilmiştir. Çok değişkenli lojistik regresyon analizi, Δ% Kreatinin ve Δ% Hemoglobin düzeylerindeki değişikliklerin mortalite riskini bağımsız olarak etkilediğini göstermiştir (sırasıyla p=0.042 ve p=0.023).

Sonuç: Çalışmamız, korunmuş ejeksiyon fraksiyonlu kalp yetmezliği tanılı hastalarda mortalite riskini artıran faktörlerin kapsamlı bir analizini sunmaktadır. Vasopressor desteği ve hemodiyaliz ihtiyacının yanı sıra belirli laboratuvar belirteçlerinin de bu hastaların yönetiminde dikkate alınması gerektiğini ortaya koymaktadır. Bulgular, gelecekteki araştırmalarda bu faktörlerin daha derinlemesine incelenmesi ve korunmuş ejeksiyon fraksiyonlu kalp yetmezliği hastalarının tedavi stratejilerinin buna göre düzenlenmesi gerektiğini vurgulamaktadır.

Keywords

Mortalite, Vazopressor, Kalp Yetmezliği, Korunmuş Ejeksiyon Fraksiyonu

Ethical Statement

Ege Üniversitesi Hastanesi Etik Kurulu çalışmayı onaylamıştır ( 18-2/28 karar numarası ).

Supporting Institution

Bu çalışma herhangi bir finansal destek almamıştır.

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