Yaş Gruplarına Göre Kemik Mineral Yoğunluğu, Kalsiyum, Fosfor, Alkalen Fosfataz, Paratiroid Hormon Düzeyleri

Year 2023, Volume: 3 Issue: 1, 64 - 67, 12.04.2023

Serap Satış , Alparslan Yetişgin , Kudret Cem Karayol

https://doi.org/10.58252/artukluder.1232582

Abstract

Bu çalışmanın amacı, total lomber1-lomber 4 ve femur boynu kemik mineral yoğunluğu, kalsiyum, fosfor, alkalen fosfataz, paratroid hormon gibi kemik sağlığını rutin değerlendirdiğimiz parametrelerin yaşa göre karşılaştırılmasıdır.
Gereç-Yöntem: Dual Enerji X-ray Absorbsiometri ile kemik mineral yoğunluğu ölçümü yapılmış olan, 40 yaş üstü 713 hasta retrospektif olarak tarandı. Sekonder osteoporozu olan hastalar çalışma dışı bırakıldı. Çalışmaya 106 hasta dahil edildi. Hastalar; Grup 1;40-49 yaş, Grup 2;50-59 yaş, Grup 3;60-69 yaş ve Grup 4;70-79 yaş olarak dört gruba ayrıldı. Hastaların Lomber 1-Lomber 4 total ve femur boynu Kemik mineral yoğunluğu, kalsiyum, fosfor, alkalen fosfataz, paratroid hormon ve D vitamini değerleri hasta dosyalarında çıkarılarak kayıt altına alındı. Gruplar arasında karşılaştırma yapıldı.
Bulgular: Kalsiyum, lomber 1-lomber 4 total ve femur boynu kemik mineral yoğunluğunda gruplar arasında istatistiksel anlamlı bulgular gözlenirken; ileri yaş hastalarda kalsiyum da yüksek gözlendi; D vitamini, fosfor, alkalen fosfataz, paratroid hormon değerlerinde, gruplar arasında fark saptanmadı. Fakat, tüm gruplarda, vitamin D seviyeleri normal değerin altındaydı.
Tartışma: D vitamini düzeyleri tüm gruplarda düşüktü. Yaşlı yetişkinlerde düşük kemik mineral yoğunluğu ve yüksek kalsiyum seviyeleri gözlemlemiştir.
Sonuç: İleri yaş olan hastalarda beklenildiği şekilde kemik mineral yoğunluğu daha düşük bulunmuştur. Ayrıca kalsiyum değeri bu grupta yüksek gözlendi; bu sonucun ileri yaş hastaların immobilizasyonuna bağlı olabileceği düşünülebilir.

Keywords

Kemik Mineral Yoğunluğu, Kalsiyum, Fosfor, Alkalen Fosfataz, Paratroid Hormon

Supporting Institution

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Project Number

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Thanks

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Bone Mineral Density, Calcium, Phosphorus, Alkaline Phosphatase, Parathyroid Hormone Levels in Age Groups

Abstract

Aim: The aim of this study is to compare the levels of lumbar 1 - lumbar 4 total, femoral neck bone mineral density, calcium, phosphorus, alkaline phosphatase, parathyroid hormone and vitamin D values which are routinely used to evaluate bone health by age.
Methods: We retrospectively reviewed 713 patients over the age of 40 who underwent dual-energy x-ray absorptiometry. Patients with secondary osteoporosis were excluded. A total of 106 patients were included in the study. The patients were divided into four groups according to their ages: Group 1; 11 patients, 40-49 years, Group 2; 42 patients, 50-59 years, Group 3; 34 patients, 60-69 years and Group 4; 10 patients, 70-79 years. Lumbar 1–lumbar 4 total and femoral neck bone mineral density, calcium, phosphorus, alkaline phosphatase, parathyroid hormone and vitamin D values were extracted from the patient files and recorded. We examined the relationships between the groups.
Results: Calcium, lumbar 1 - lumbar 4 total and femoral neck bone mineral density were statistically significant between the groups; the highest calcium value was observed among group 4 patients, and the comparison between the groups was statistically significant. There was no difference, in vitamin D, phosphorus, alkaline phosphatase and parathyroid hormone levels between the groups. Vitamin D levels were low in all groups.
Discussion: Vitamin D levels were low in all groups. Older adults also observed low bone mineral density (BMD) and high calcium levels.
Conclusion: Lower bone mineral density in patients with advanced age was as expected. In addition, a high calcium value was observed in this group; this result may be thought to be due to the immobilization of elderly patients.

Keywords

Bone Mıneral Density, Calcium, Phosphorus, Alkaline Phosphatase, Parathyroid Hormone

Project Number

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References

• Dimai, Hans. Use of dual-energy X-ray absorptiometry (DXA) for diagnosis and fracture risk assessment; WHO-criteria, T- and Z-score, and reference databases. Bone. 2017;104:39-43. 10.1016/j.bone.2016.12.016.
• Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1-129.
• Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr. 2003;22(2):142-6.
• Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40-9.
• Kang KY, Hong YS, Park SH, Ju JH. Increased serum alkaline phosphatase levels correlate with high disease activity and low bone mineral density in patients with axial spondyloarthritis. Semin Arthritis Rheum. 2015;45(2):202-7.
• Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon MC, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
• Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007;18(8):1033–46.
• Holick MF. Calcium and vitamin D, Diagnostics and therapeutics. Clin Lab Med. 2000;20(3):569-90.
• Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007;103(3):620-5.
• Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J. Endocrinol Invest. 2000;23(3):173-7.
• Sarıdoğan M, Akarırmak Ü, Eskiyurt N, Tüzün Ş. Türkiye'nin 3 farklı coğrafi bölgesindeki postmenopozal kadınlarda D vitamini ve kemik mineral yoğunluğunun korelasyonu - orijinal araştırma. Turk J Osteoporos. 2010;16(3):49-52.
• Rabenda V, Bruyère O, Reginster Y. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: A meta-regression. Osteoporosis International. 2011;22(3):893–901.
• Bahtiri E, Islami H, Hoxha R, Bytyqi HQ, Sermaxhaj F, Halimi E. Calcium and dairy products consumption and association with total hip bone mineral density in women from Kosovo. Med Arch. 2014;68(4):259–62.
• Bristow SM, Horne M, Gamble GD, Mihov B, Stewart A, Reid IR. Dietary calcium intake and bone loss over 6 years in osteopenic postmenopausal women. The Journal of Clinical Endocrinology&Metabolism. 2019;104(8):3576–84.
• Silva BC, Bilezikian JP. Parathyroid hormone: Anabolic and catabolic actions on the skeleton. Curr Opin Pharmacol. 2015;22:41-50. doi:10.1016/j.coph.2015.03.005.
• Oldroyd A, Dubey S. The association between bone mineral density and higher body mass index in men. Int J Clin Pract. 2015;69(1):145-7.