CYP1A2 (Sitokrom P450 1A2) Genotiplerine (AA, AC, CC) Göre Kafein Metabolizma Hızlarının Atletik Performansa Etkileri

Year 2022, , 713 - 726, 23.12.2022

Sibel Tetik Dündar

https://doi.org/10.38021/asbid.1199261

Abstract

Kafein, psikoaktif etkileri nedeniyle uyarıcı olarak birçok insanın tercihi halini almıştır. Farklı türevleri ile birçok alan ve amaçla kullanılan kafein, egzersiz üzerindeki etkileri ile de spor bilimciler tarafından yakından takip edilmektedir. Yine, uzun yıllardır araştırılan bir konu olarak kafein ve genotip ilişkisi, ülkemiz için azınlıkta ve yeni sayılabilir. Bu çalışma, karaciğerde kafein metabolizmasından sorumlu Sitokrom P450 1A2 enzimini kodlayan CYP1A2 genotiplerine göre, kafein metabolizma hızlarının performansa etkisini incelemek amacıyla yapılmıştır. Çalışma, derleme türünde, konu ile yakından ilgili çalışmaların araştırılması, incelenmesi ve sonuçların yorumlanması oluşturulmuştur. İlgili araştırma sonuçlarına yoğun olarak, ulusal tıp kütüphanesi temelinde bilimsel araştırmalar içeren PubMed.gov sitesinden ulaşım sağlanmıştır. Kafein üzerine yapılan çalışmalarda, alım zamanı, dozu, egzersiz tipi gibi parametrelerde daha net ifadeler görülürken, sonuçların genotip ile olan ilişkisi ve nedeni ile ilgili henüz tam anlamıyla net ifadeler oluşmamıştır. Çünkü, kafein ile genotip ilişkisinde olumlu sonuçlar gösteren çalışmaların oranı kadar olumsuz sonuçlar gösteren çalışmalar da mevcuttur. Bu da çelişkiye neden olmaktadır. Şu anda, mevcut veriler, hangi genotipin kafein takviyesinden en fazla faydayı görebileceğini belirtmek için yetersiz gibi görünmektedir. AA homozigotlarının varlığını gösteren bazı kanıtlar olsa da zayıftır. Bu nedenle, CYP1A2 genotipini belirlemek için yapılan genetik testler şu anda yeterli sonuçlara ulaşma olanağı vermediğinden gerekli olup olmadığının tartışmaya açık olduğu düşünülmektedir.

Keywords

Cyp1a2, Kafein, Genotip, Atletik Performans, Egzersiz

The Effects of Caffeine Metabolism Velocity on Athletic Performance According To CYP1A2 (Citocrome P450 1A2) Genotypes (AA, AC, CC)

Abstract

Times Caffeine has become the choice of many people as a stimulant due to its psychoactive effects. Caffeine, which is used in many fields and purposes with its different derivatives, is closely followed by sports scientists with its effects on exercise. Again, as a subject that has been researched for many years, the relationship between caffeine and genotype can be considered a minority and new for our country. This study was carried out to examine the effect of caffeine metabolism rates on performance according to CYP1A2 genotypes encoding the Cytochrome P450 1A2 enzyme responsible for caffeine metabolism in the liver. The study was formed in the type of compilation, researching and examining the studies closely related to the subject and interpreting the results. The relevant research results were accessed from the PubMed.gov site, which contains scientific research on the basis of the national medical library. In studies on caffeine, clearer expressions were observed in parameters such as intake time, dose, and exercise type, but there was no clear statement yet about the relationship between the results and the genotype and the reason. Because there are studies showing negative results as well as a ratio of studies showing positive results in the relationship between caffeine and genotype. This causes a contradiction. Currently, the available data appear to be insufficient to indicate which genotype may see the most benefit from caffeine supplementation. There is some evidence for the existence of AA homozygotes, but it is weak. Therefore, it is controversial whether genetic testing to determine the CYP1A2 genotype is necessary, as it currently does not provide sufficient results.

Keywords

Cyp1a2, Caffeine, Genotype, Athletic Performance, Exercise

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