Otizm Spektrum Bozukluklarında Beslenme Yaklaşımı

Year 2019, Volume: 5 Issue: 2, 111 - 119, 12.09.2019

Gözde Gürsoy Serap Öztürk

Abstract

Bu çalışmanın amacı, otizm spektrum bozukluğunda uygulanabilecek

diyetsel yaklaşımların derlenmesidir. Otizm spektrum bozukluğu,

sosyal iletişim ve sosyal etkileşimde yetersizliklerin yanı sıra kısıtlı

ve tekrarlayan davranış, anormal ilgi ve etkinliklerin sergilenmesi ile

karakterize gelişimsel bir bozukluktur. Glütensiz-kazeinsiz eliminasyon

diyeti ile bazı makro ve mikro besin ögelerinin suplementasyonunun otizm

semptomlarını iyileştirdiğine dair veriler mevcut olmakla birlikte, otizmde

etkili olabilecek diyet tedavisinin kesin olarak belirlenmesi için geniş

kapsamlı kontrollü çalışmalara ihtiyaç duyulmaktadır.

Keywords

Otizm spektrum bozukluğu, beslenme, diyet, mikrobiyot

References

• [1] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing, 2013. The web site: https://psycnet.apa.org/record/2013-14907-000 [2] Kałuzna-Czaplinska, J., Jozwik-Pruska, J. Nutritional strategies and personalized diet in autism-choice or necessity?. Trends in Food Science & Technology, 2016, 49: 45-50. [3] Essa, M.M., Subash S., Braidy N et al. Role of NAD+, oxidative stress, and tryptophan metabolism in autism spectrum disorders. Int J Tryptophan Res, 2013, 6: 15-28. [4] Aponte, C.A., Romanczyk, R.G. Assessment of feeding problems in children with autism spectrum disorder. Research in Autism Spectrum Disorders, 2016, 21: 61-72. [5] Berding, K., Donovan, S.M. Microbiome and nutrition in autism spectrum disorder: current knowledge and research needs. Nutrition Reviews, 2016, 74(12): 723-736. [6] Ranjan, S., Nasser, J.A. Nutritional status of individuals with autism spectrum disorders: Do we know enough?. Adv Nutr, 2015; 6: 397-407. [7] Fujiwara, T., Morisaki, N,, Honda, Y., Sampei, M., Tani, Y. Chemicals, nutrition, and autism spectrum disorder: a mini – review. Front Neurosci, 2016, 10: 174-181. [8] Elder, J.H. The glüten-free, casein-free diet in autism: an overview with clinical ımplications. Nutr Clin Pract, 2008, 23(6): 583-591. [9] Kraneveld, A.D., Szklany, K., de Theije, C.G., Garssen, J. Gut-to-brain axis in autism spectrum disorders: central role for the microbiome. Int Rev Neurobiol, 2016, 131: 263-287. [10] Piwowarczyk, A., Horvath, A., Lukasik, J., Pisula, E., Szajewska, H. Glüten‑ and casein‑free diet and autism spectrum disorders in children: a systematic review. Eur J Nutr, 2018, 57: 433-440. [11] Hyman, S.L., Stewart, PA., Foley, J. et al. The glüten-free/casein-free diet: a double-blind challenge trial in children with autism. J Autism Dev Disord, 2016, 46: 205-220. [12] Brigandi, S.A., Shao, H., Qian, S.Y. et al. Autistic children exhibit decreased levels of essential fatty acids in red blood cells. Int J Mol Sci, 2015, 16: 10061-10076. [13] Gogou, M., Kolios, G. The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literatüre. Brain & Development, 2017, 39: 656-664. [14] Mousain-Bosc, M., Roche, M., Polge, A. et al. Improvement of neurobehavioral disorders in children supplemented with magnesiumvitamin B6. II. Pervasive developmental disorder-autism. Magnes Res, 2006, 19: 53-62. [15] Stewart, P.A., Hyman, S.L., Schmidt, B.L. et al. Dietary supplementation in children with autism spectrum disorders: common, insufficient, and excessive. J Acad Nutr Diet, 2015, 115: 1237-1248. [16] Liu, J., Liu, X., Xiong, X.O. et al. Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study. BMC Microbiology, 2017, 17: 204-218. [17] Evrensel, A., Ceylan, M.E., Bağırsak beyin ekseni: Psikiyatrik bozukluklarda bağırsak mikrobiyotasının rolü. Psikiyatride Güncel Yaklaşımlar, 2015, 7(4): 461-472. [18] Flandroy, L., Poutahidis, T., Berg, G. et al. The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems. Science of the Total Environment, 2018, 627: 1018- 1038. [19] Li, Q., Zhou, J.M. The microbiota–gut–brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience, 2016, 324: 131-139. [20] Ly, V., Bottelier, M., Hoekstra, P. et al. Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry, 2017, 26: 1067-1079.