Comparison of antimicrobial effects of different propofol ketamine combinations

Year 2022, Volume: 8 Issue: 3, 265 - 280, 30.10.2022

Döndü Genç Moralar , Mehmet Demirci , Sevgi Kesici , H Aysel Altan , Ugur Kesıcı

Abstract

Introduction: The combined use of ketamine and propofol has been frequently preferred in general anesthesia applications in recent years. The aim of this study was to determine the reliable combination to prevent infection development by comparing different combinations of ketamine and propofol and safe usage period of the combination.
Methods: In the present study S. aureus, K. pneumoniae, E. coli, P. aeruginosa and C. albicans microorganisms were used. The turbidity data obtained at different hours and the zero-hour turbidity data were compared to determine the effect of microorganisms when they were kept at room temperature following the contamination of ketamine, propofol, and different ketamine + propofol mixtures by these microorganisms.
Results: For each microorganism studied, the growth rate within the first 36 hours was observed to be higher in the propofol group compared to the ketamine group and other ketamine + propofol groups. For each microorganism studied, the growth rate was observed to be lower at all time periods in the ketamine group compared to the propofol group and other ketamine + propofol groups. The growth rate was observed to be less when the ketamine ratio increased in the ketamine + propofol mixture for all microorganisms.
Conclusion: The growth rate was observed to be less in ketamine + propofol combinations due to the antibacterial effect of ketamine, compared to the group in which only propofol was used.

Keywords

Antimicrobial, propofol, ketamine, ketofol, intravenous anesthesia, sedation, intensive care

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