Akciğer Tüberkulozu ve AkciğerKanserli Hastalarda Serum MalondialdehidSeviyesi ve Süperoksid Dismutaz Aktivitesi

Year 2004, , 33 - 38, 01.05.2004

Yıldız Güney Ayşe Bilgihan Ulukavak Çiftçi Tansu Filiz Çimen Özgür Coşkun

https://doi.org/10.1501/Ashd_0000000052

Abstract

Giriş: Artan orandaki epidemiyolojik ve deneysel çalışmalar serbest radikal aktivitesi ile malignensi arasında yakın ilişki olduğunu göstermiştir. Kanser ve tüberkuloz (tb) gibi dejeneratif hastalıklarda serbest radikal
oluşumu ile hücresel savunma mekanizması
arasındaki dengesizlik tariflenmiştir.
Yöntem: Bu çalışmada akciğer kanserli (Ac Ca) ve tb’lu hastaların serumlarında lipid peroksid seviyesi ve antioksidan bir enzim olan süperoksit dismutaz aktivitesi incelenmiştir. Kırkiki hasta ve ondört sağlıklı gönüllü bu çalışmaya dahil edilmiştir. Malondialdehid (MDA) ve superoksid dismutaz (SOD)
aktivitesi serumlarında tespit edildi.
Sonuçlar: Serum MDA seviyeleri tüm
hasta grubunda (Ac Ca ve tb) kontrol grubuna gore daha yüksek bulunmuştur. MDA düzeylerinde grup I ile grup II arasında belirgin fark göstermemektedir (p>0,05). Ac Ca’li hastaların serumlarında incelenen SOD aktivitesi diğer iki gruba göre belirgin olarak düşüktür. Grup I’deki SOD aktivitesi grup II ile karşılaştırıldığında anlamlı azalma tespit edilmiştir (p<0,001). Bu çalışmada, LP seviyesi hem tb’li hem de Ac Ca’li hastalarda yüksek olmasına karşın, SOD aktivitesi Ac Ca’li hastalarda tb’lu hastalara göre belirgin yüksektir

Keywords

Akciğer kanserleri, tuberkuloz, lipid peroksidasyon, superoksid dismutaz

SERUM MALONDIALDEHYDE LEVELS AND SUPEROXIDE DISMUTASE ACTIVITIES IN PULMONARY TUBERCULOSIS AND

Abstract

Objectives: An increasing amount of
epidemiological and experimental evidence has
been carried out on the relationship between
free radical activity and malignancy. The
imbalance between free radical production and
cellular defense mechanisms has been
described in cancers and degenerative diseases
like tuberculosis (tb).
Methodology: The present investigation
has been undertaken to study the levels of lipid
peroxide (LP) and antioxidant enzyme
superoxide dismutase (SOD) activities in sera
of lung cancers (Lc) and tb. Forty-two patients
and fourteen healthy cases were enrolled into
the study. Group I had seventeen subjects with
Lc, group II had twenty-five patients with tb
and group III had fourteen healthy cases. The
malondialdehide (MDA) and superoxide
dismutase (SOD) activities in sera were
quantified.
Results: Serum MDA levels in the whole
group of patients (Lc and tb) were much higher
than in healthy controls. The levels of MDA
did not change significantly in the group I vs.
group II (p>0,05). The SOD activity in sera
from patients with Lc was markedly lower than
the other two groups. Activities of SOD in
group I significantly decreased as compared to
the group II (p<0,001). In the present study
although LP levels increased in both tb and Lc
patients, the activities of SOD in Lc cases were
significantly higher than tb patients.

Keywords

lung cancers, tuberculosis, lipid peroxidation, superoxide dismutase

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